Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations

Abstract

BackgroundMaonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations.MethodsGenotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing.ResultsThe frequencies of CC, CG and GG genotypes of the APOA1 rs964184 SNP were 68.86, 29.18 and 1.96% in the Maonan population, and 63.78, 30.85 and 5.37% in the Han population (P < 0.001). The frequency of the G allele was 16.55% in Maonan and 20.79% in Han (P < 0.001). The G allele carriers had lower high-density lipoprotein cholesterol (HDL-C) levels in Maonan and higher triglyceride (TG) levels in Han peoples than the G allele non-carriers. Subgroup analyses showed that the G allele carriers had lower HDL-C levels in both Maonan males and females; and lower apolipoprotein (Apo) A1 levels and the ApoA1/ApoB ratio in Han males than the G allele non-carriers. Serum lipid parameters in the two ethnic groups were also associated with several environmental factors.ConclusionsThe present study reveals that there may be a racial/ethnic- and/or gender-specific association between the APOA1 rs964184 SNP and serum lipid parameters in our study populations.Trial registrationRetrospectively registered.

Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

“…APOA-I and APOB levels are not only influenced by environmental factors, such as diet and exercise, but are also subject to genetic regulation [31,32]. Thus, APOA-I and APOB genetic variations may have a causal effect on insulin resistance and MetS.…”

“…Previous studies have focused on the relationship between APOA-I and APOB genetic variations and serum lipid traits [31,33,34]. It had been reported that there was an ethnic and gender specific association between the APOA rs964184 with lower HDL-C, higher TG and lowers APOA levels in Chinese populations [31]. The sample was small, and the results were lack of the consideration of the impact of other SNP and diseases on serum lipids levels.…”

Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea

“…APOA-I and APOB levels are not only in uenced by environmental factors, such as diet and exercise, but are also subject to genetic regulation [31,32]. Thus, APOA-I and APOB genetic variations may have a causal effect on insulin resistance and MetS.…”

“…Previous studies have focused on the relationship between APOA-I and APOB genetic variations and serum lipid traits [31,33,34]. It had been reported that there was an ethnic and gender speci c association between the APOA rs964184 with lower HDL-C, higher TG and lowers APOA levels in Chinese populations [31]. The sample was small, and the results were lack of the consideration of the impact of other SNP and diseases on serum lipids levels.…”

Nutrigenetic Contributions to Dyslipidemia: A Focus on Physiologically Relevant Pathways of Lipid and Lipoprotein Metabolism

“…APOA1 is the predominant apolipoprotein on HDL particles and essential in RCT function and HDL formation. Variants in this gene have been associated with blood lipids in both European and Chinese populations [ 16 , 24 ]. HL is involved in the remodeling of HDL particles, and thus facilitates RCT [ 25 ].…”