Association of the Apolipoprotein B/Apolipoprotein A-I Ratio, Metabolic Syndrome Components, Total Cholesterol, and Low-Density Lipoprotein Cholesterol with Insulin Resistance in the Population of Georgia

Makaridze, Zaza; Giorgadze, Elene; Asatiani, Ketevan

doi:10.1155/2014/925650

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…In addition, some researchers reported that IR can promote NAFLD development by inducing TG decomposition of within adipose tissue and simultaneously enhancing TG synthesis in the liver [ 41 , 42 ]. On contrary, IR emergence accelerates sugar decomposition, leading to an enhancement in blood glucose and VLDL, which then promotes the release of excessive TC into the blood, thus raising serum TC levels [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults

Liu

Wang

2022

Lipids Health Dis

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Background Lipid accumulation product (LAP) and cardiometabolic index (CMI) are two novel obesity-related indexes associated with enhancing metabolic disease (MD) risk. Current evidences suggest that the differences in sex hormones and regional fat distribution in both sexes are directly correlated with MD and nonalcoholic fatty liver disease (NAFLD) risk. Hence, NAFLD incidences reflect sex differences. Herein, we examined the accuracy of LAP and CMI in diagnosing NAFLD in both sexes. Methods Overall, 14,407 subjects, who underwent health check-up in the northeastern China, were enrolled in this study, and their corresponding LAP and CMI were calculated. Abdominal ultrasonography was employed for NAFLD diagnosis. Multivariate analyses were analyzed potential correlations between LAP and/or CMI and NAFLD. Odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated. Receiver operating characteristic curve analyses was executed for the exploration of the diagnostic accuracies. Areas under the curves (AUCs) with 95%CIs were calculated. Results NAFLD prevalence increased with elevated quartiles of LAP and CMI in both sexes. In multivariate logistic regression analyses, LAP and CM expressed as continuous variables or quartiles, significantly correlated with NAFLD. The ORs for the top versus bottom quartile of LAP and CMI for NAFLD were 13.183 (95%CI = 8.512–20.417) and 8.662 (95%CI = 6.371–11.778) in women and 7.544 (95%CI = 5.748–9.902) and 5.400 (95%CI = 4.297–6.786) in men. LAP and CMI exhibited larger AUCs, compared to other obesity-related indexes in terms of discriminating NAFLD. The AUCs of LAP and CMI were 0.860 (95%CI = 0.852–0.867) and 0.833 (95%CI = 0.825–0.842) in women and 0.816 (95%CI = 0.806–0.825) and 0.779 (95%CI = 0.769–0.789) in men. Conclusions LAP and CMI are convenient indexes for the screening and quantification of NAFLD within a Chinese adult population. Their associations with NAFLD are substantially greater in women than men.

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Section: Discussionmentioning

confidence: 99%

Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults

Liu

Wang

2022

Lipids Health Dis

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“…A population-based study in Georgia revealed that insulin resistance (HOMA-IR) was positively correlated with age, apoB, apoB/apoA-I ratio, metabolic syndrome components (excluding HDL-C), LDL-C, fasting insulin, and TC and negatively correlated with HDL-C and apoA-I in both genders. In the logistic regression models, gender, age, apoB/apoA-I ratio, diastolic pressure, HDL-C, LDL-C, FBG, and TG were the covariates significantly associated with IR 13. Environmental factors such as smoking influenced the lipid profile (by aggravating atherogenic dyslipidemia) in subjects with insulin resistance 14.…”

Section: Discussionmentioning

confidence: 99%

<p>Dyslipidemia in diabetes: a population-based study in Bali</p>

Suastika

Semadi

Dwipayana

et al. 2019

IJGM

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Purpose To establish the lipid pattern in subjects with diabetes mellitus (DM) and factors that are correlated with insulin resistance and lipid disorders in a population of Bali. Methods A cross-sectional population-based study which enrolled 1840 subjects (age 13–100 years) from 7 villages was carried out. Several clinical parameters were measured including age, gender, body mass index, waist circumference (WC), fasting blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) A (apoA), apoB, non-HDL-C, T/HDL-C ratio, LDL-C/apoB ratio, apoB/A ratio, plasma insulin, and homeostasis of model assessment-insulin resistance (HOMA-IR). Results TC, TG, and non-HDL-C levels were higher in DM subjects than in normal glucose tolerance (NGT) subjects in both genders; total/HDL-C ratio was higher in subjects with DM than in NGT subjects only in men; LDL-C levels, apoB levels, and apoB/A ratios were higher and LDL/apoB was lower in subjects with DM than in NGT in women. In subjects with DM, the target for LDL-C (79%), non-HDL-C (85.2%), apoB (80%), HDL-C (34.9%), TG (46.7%), and small-dense low density lipoprotein (42.2%) was not achieved. Conclusion FBG was correlated with TC, TG, LDL-C, apoB, non-HDL-C levels, LDL/apoB, and apoB/apoA ratios. Subjects with DM had higher levels of TC, TG, and non-HDL-C levels in both genders; T/HDL-C ratio only in men; LDL-C, apoB/apoA ratio and lower LDL/apoB ratio only in women. Obesity was correlated with lipid levels. WC was correlated with LDL/apoB ratio, insulin level, HOMA-IR, and TG; highest absolute strength of correlation was with LDL/apoB ratio. Insulin resistance was correlated with lipid levels or ratios, especially in women. In women, HOMA-IR had a positive correlation with total/HDL-C ratio, non-HDL-C, apoB, and a negative correlation with HDL-C levels.

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“…Furthermore, the plasma concentration of ApoB indicates the total number of potentially atherogenic particles, correlating with the non-HDL-C levels. The ApoB/ApoA ratio is a better indicator of the risk of coronary artery disease compared to LDL-C. A study reported that physical activity can effectively decrease body fat percentage, and increased ApoB metabolism can affect LDL metabolism (25). Variation in circulating concentrations of factors such as lecithin cholesterol acyltransferase, acyl-CoA cholesterol acyltransferase, cholesteryl ester transfer protein, and phospholipid transfer protein due to exercise activity can affect the concentration of ApoA (26).…”

Section: / Moazami and Askarimentioning

confidence: 99%

Effect of Six Months of Aerobic Exercise on Lipid Profile, Inflammatory Markers and Risk Factors of Cardiovascular Disease in Obese Women

Moazzami

Askari

2018

mljgoums

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Background and objectives: The aim of this study was to investigate the effects of six months of aerobic exercise on lipid profile, inflammatory markers, and risk factors of cardiovascular disease in middle-aged obese women.Methods: Fifteen obese woman (age range: 35 to 45 years) with BMI of ≥30 Kg/m 2 were enrolled via purposeful and convenience sampling. The participants were randomly divided into training (n=10) and control (n=5) groups. Blood samples (7 ml) were taken from all participants before the first training session and after the last training session. The women performed 60 minutes of aerobic exercise at 55-65% of heart rate reserve, three sessions a week, for six months. Data was analyzed using independent and paired t-tests and Mann-Whitney U and Wilcoxon tests at significance of 0.05.Results: After the six-month aerobic exercise, C-reactive protein, low-density lipoprotein, triglycerides, total cholesterol and high-density lipoprotein/total cholesterol decreased significantly. The exercise intervention also caused a significant increase in the concentrations of high-density lipoprotein and apolipoprotein A. Exercise, physical activity, and endurance training can act as therapeutic factors for patients with atherosclerosis (11). Recent studies show that regular exercise can lower LDL levels by 5% and subsequently increase HDL by 3 to 6% (12). Long-term exercise directly reduces CRP levels by decreasing cytokine production in adipose tissue, muscles, and mononuclear cells and increasing insulin sensitivity, all of which contribute to weight loss and improvement of endothelial function (13). In recent years, the protein component of lipoproteins has attracted the attention of researchers, and many studies have shown that serum levels of HDL and LDL depend on the production of ApoA and ApoB. In addition, ApoA and ApoB levels have a negative and positive correlation with risk of cardiovascular disease, respectively (14). Hence, this study evaluated the effects of six months of aerobic training on lipid profile, inflammatory markers, and cardiovascular risk factors in middle-aged obese women (with BMI of ≥30). Conclusion MATERIAL AND METHODSFifteen obese woman (age range: 35 to 45 years) with BMI of ≥30 Kg/m 2 were enrolled via purposeful and convenience sampling. After obtaining consent and completion of a health questionnaire, the participants were randomly divided into training (n=10) and control (n=5) groups. Exclusion criteria included drug use, menopause, smoking, and regular exercise in the last six months. First, anthropometric characteristics such as height, weight, and BMI of the women were recorded. Then, they participated in a briefing before the start of the training protocol. To evaluate the variables under study, fasting blood samples (7 ml) were taken from all participants in a sitting position before the first training session (pretest) and after complication of the last training session (post-test). The women performed 60 minutes of aerobic exercise, three sessions a week, for ...

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Association of the Apolipoprotein B/Apolipoprotein A-I Ratio, Metabolic Syndrome Components, Total Cholesterol, and Low-Density Lipoprotein Cholesterol with Insulin Resistance in the Population of Georgia

Cited by 10 publications

References 34 publications

Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults

Sex-specific contribution of lipid accumulation product and cardiometabolic index in the identification of nonalcoholic fatty liver disease among Chinese adults

<p>Dyslipidemia in diabetes: a population-based study in Bali</p>

Effect of Six Months of Aerobic Exercise on Lipid Profile, Inflammatory Markers and Risk Factors of Cardiovascular Disease in Obese Women

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