Association of the Apolipoprotein E Variants with Susceptibility to Pregnancy with Preeclampsia

Jamalzei, B.; Fallah, Soudabeh; Kashanian, Maryam; Seifi, Morteza

doi:10.7754/clin.lab.2012.120304

Cited by 5 publications

(5 citation statements)

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“…The diverging conclusions of their study are probably caused by the small sample-size ( n = 141 with 47 patients suffering on preeclampsia) with ApoE e4 not being normally distributed in their control group. Other authors did not find associations of ApoE genotype and the risk of preeclampsia when genotyping the mother [27–29] which corresponds with our observations in the fetus.…”

Section: Discussionsupporting

confidence: 90%

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Norda

Rausch

Orlikowsky

et al. 2017

BioMed Research International

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Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (≥22+0 and <32+0 weeks of gestation and birth weight below 1500 g) from the GNN study cohort was analyzed. Neonates were categorized into subgroups of <3rd, 3rd–10th, and >10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan® SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.

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Section: Discussionsupporting

confidence: 90%

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Norda

Rausch

Orlikowsky

et al. 2017

BioMed Research International

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“…No studies have reported associations of apolipoproteins with pre-eclampsia in samples as large as the current study [20,[25][26]. As a result, the strong associations observed for ApoE and the ApoB/ApoA1 ratio deserve further mention.…”

Section: Discussioncontrasting

confidence: 49%

“…ApoB, on the other hand, is the main component of LDL cholesterol (constituting up to 80%) and very low density lipoproteins (VLDL, constituting up to 40%). ApoE is the main component of VLDL, and is responsible for modifying inflammatory responses and removing excess cholesterol from circulation by regulating the absorption of lipids in the liver [20].…”

Section: Discussionmentioning

confidence: 99%

“…The potential association between maternal levels of apolipoproteins and pre-eclampsia has also been investigated. Apolipoproteins are proteins involved in the mediation of inflammatory responses and removal of excess cholesterol from the circulation [20]. In particular, the ApoE isoforms and gene variants have been postulated and highlighted as potential predictors of pre-eclampsia development [21][22].…”

Section: Introductionmentioning

confidence: 99%

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Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study

et al. 2018

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“…In fact based on the data presented here, it seems that APOE upregulation may occur very early in oncogenic development to help support and maintain the abnormal cells. Caution should be taken when evaluating only APOE levels in female patients because preeclampsia can also elevate plasma APOE levels [45]. The biological mechanism by which APOE is upregulated and how it supports tumor growth is not clear, however, it could be speculated that elevated APOE could provide much needed cholesterol for the actively growing cancer cells [46].…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung

et al. 2015

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Biomarkers to identify subjects at high-risk for developing lung cancer will revolutionize the disease outlook. Most biomarker studies have focused on patients already diagnosed with lung cancer and in most cases the disease is often advanced and incurable. The objective of this study was to use proteomics to identify a plasma biomarker for early detection of lung lesions that may subsequently be the harbinger for cancer. Plasma samples were obtained from subjects without lung cancer grouped as never, current, or ex-smokers. An iTRAQ-based proteomic analysis was performed on these pooled plasma samples. We identified 31 proteins differentially abundant in current smokers or ex-smokers relative to never smokers. Western blot and ELISA analyses confirmed the iTRAQ results that demonstrated an increase of apolipoprotein E (APOE) in current smokers as compared to both never and ex-smokers. There was a strong and significant correlation of the plasma APOE levels with development of premalignant squamous metaplasia. Additionally, we also showed that higher tissue levels of APOE are seen with squamous metaplasia, supporting a direct relationship. Our analysis reveals that elevated plasma APOE is associated with smoking, and APOE is a novel predictive protein biomarker for early morphological changes of squamous metaplasia in the lung.

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Association of the Apolipoprotein E Variants with Susceptibility to Pregnancy with Preeclampsia

Cited by 5 publications

References 0 publications

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study

Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung

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