Association of the atherogenic index of plasma with cardiovascular risk beyond the traditional risk factors: a nationwide population-based cohort study

Kim, Si Hyoung; Cho, Yun Kyung; Kim, Ye‐Jee; Jung, Chang Hee; Lee, Woo Je; Park, Joong‐Yeol; Huh, Ji Hye; Kang, Jun Goo; Lee, Seong Jin; Ihm, Sung-Hee

doi:10.1186/s12933-022-01522-8

Cited by 75 publications

(47 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The AIP could be also considered an independent predictor of CVD incidence and mortality risk ( 38 , 41 ). Results from a large-scale nationwide population cohort study carried on in the Republic of Korea showed that AIP HRs for CVD risk were higher as compared to HRs of triglycerides and HDL cholesterol when those variables were applied in the regression model alone ( 42 ). Whereas, a study performed among 1,131 male patients with angiographically diagnosed CAD and without CAD found that the AIP predictive value for diagnosing CAD was not significantly different as compared with traditional blood lipids ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Tamošiūnas

Lukšienė

Krančiukaitė-Butylkinienė

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundTwo indices: visceral adiposity index (VAI) and atherogenic index of plasma (AIP) during several recent years were implemented into epidemiological studies for predicting of cardiovascular diseases (CVD) and mortality risk. Our study aimed to evaluate the association of VAI and AIP with the risk of all-cause and CVD mortality among the Lithuanian urban population aged 45–72 years.MethodsIn the baseline survey (2006–2008), 7,115 men and women 45–72 years of age were examined within the framework of the international study Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE). Six thousand six hundred and seventy-one participants (3,663 women and 3,008 men) were available for statistical analysis (after excluding 429 respondents with the missed information on study variables) and for them, VAI and AIP were calculated. The questionnaire evaluated lifestyle behaviors, including smoking and physical activity. All participants in the baseline survey were followed up for all-cause and CVD mortality events until December 31st, 2020. Multivariable Cox regression models were applied for statistical data analysis.ResultsAfter accounting for several potential confounders, higher levels of VAI (compared 5th quintile to 1st quintile) were associated with significantly higher CVD mortality in men [Hazards ratio (HR) = 1.38] and all-cause mortality in women (HR = 1.54) after 10-year follow-up. CVD mortality significantly increased in men with 0 the highest AIP quintile compared with that for the lowest quintile (HR = 1.40). In women, all-cause mortality was significantly higher for the 4th quintile of AIP as compared with the 1st quintile (HR = 1.36).ConclusionsHigh-risk VAI levels were statistically significantly associated with all-cause mortality risk in men and women groups. The higher AIP level (5th quintile vs. 1st quintile—in men and 4th quintile vs. 1st quintile—in women) was significantly associated with increased mortality from CVD in the men group and increased all-cause mortality in the women group.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Tamošiūnas

Lukšienė

Krančiukaitė-Butylkinienė

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…AIP was used to calculate atherosclerosis risk; its use in women with PCOS has been previously demonstrated in the literature [ 60 ]. The AIP is based on a positive association with lipoprotein particle size, cholesterol esterification rates, and remnant lipoproteinemia, and it is even recommended as a sole marker of cardiovascular diseases (CVD) [ 61 ]. AIP values of −0.3 to 0.1 are associated with a low risk of CVD, values of 0.1 to 0.24 with a medium risk, and values above 0.24 with a high risk [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Intake of Low Glycaemic Index Foods but Not Probiotics Is Associated with Atherosclerosis Risk in Women with Polycystic Ovary Syndrome

Bykowska-Derda

Kałużna

Garbacz

et al. 2023

Life

View full text Add to dashboard Cite

Women with polycystic ovary syndrome (PCOS) are at high cardiometabolic risk. The atherogenic index of plasma (AIP) strongly predicts atherosclerosis. Some studies suggest that probiotic intake may lower AIP. This study analysed the relationship between the frequency of dietary intake of low glycaemic index (prebiotic) and probiotic foods and atherosclerosis risk in women with PCOS. Methods: A total of 127 women were divided into two groups: AIP over 0.11 (highAIP) and AIP ≤ 0.11 (lowAIP). The KomPAN® questionnaire was used to measure food frequency intake; pro-healthy, non-healthy, low glycaemic and probiotic dietary indexes were calculated based on daily food consumption. Body composition was measured by air displacement plethysmography (BodPod). AIP was calculated as a logarithm of triglycerides and high-density lipoproteins from plasma. Results: The highAIP group was 63% less likely to consume low glycaemic index foods three or more times a day than the lowAIP group. The HighAIP group was also 62% less likely to consume buckwheat, oats, whole-grain pasta or coarse-ground grains at least a few times a week. Pro-healthy foods tended to be less frequently consumed by the highAIP group, when adjusted for BMI and age. Conclusion: Women with PCOS at high risk of atherosclerosis consumed less low glycaemic index foods than women with a low risk of atherosclerosis. Intake of high-fibre, low glycaemic index foods could prevent atherosclerosis in women with PCOS; however, the effect of probiotic food intake remains unclear.

show abstract

“…identified that the TyG index was closely associated with the severity and morbidity in COVID-19 patients ( 34 ). As for AIP, it is a substitute for small, dense low-density lipoprotein-cholesterol (sdLDL-C) particles and is inversely related to the LDL-C particle diameter ( 35 ). As a marker of plasma atherogenicity, AIP has proven to be a good predictive and prognostic biomarker for cardiovascular events as well as the best predictor of hypertension and diabetes ( 36 – 38 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride glucose index and Atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases

et al. 2022

View full text Add to dashboard Cite

Background and aimsColorectal neoplasms (CRN) include colorectal cancer (CRC) and colorectal adenoma (CRA). The relationship between CRN and triglyceride-glucose (TyG) index or between CRN and atherogenic index of plasma (AIP) is unclear. This study aims to investigate the roles of TyG index and AIP in predicting CRN in people without cardiovascular disease (CVD).Methods2409 patients without CVD underwent colonoscopy were enrolled. Clinical information and relevant laboratory test results of these patients were collected and recorded. According to endoscopic and pathological results, all participants were divided into a neoplasms group and a non-neoplasms group. The TyG index was calculated as ln (TGs×FPG/2), while AIP was calculated as log (TGs/HDL-C). We used uni- and multivariate logistic regression and restricted cubic spline (RCS) to analyze the association between the TyG inedx, AIP and CRN, develop predictive models and construct the nomograms. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive value for CRN.ResultsParticipants in the neoplasms group were more likely to be older, have higher TyG index, higher AIP and higher rates of fecal occult blood test positivity, and were more likely to be male, smokers and those with the family history of CRC (P < 0.05). The higher TyG index was related to the higher risk of CRN [OR (95% CI): 1.23 (1.08 - 1.41), P = 0.003]. The higher AIP was related to the higher risk of CRN [OR (95% CI): 1.55 (1.16 - 2.06), P = 0.003]. These two indicators are better for predicting CRN in women than men. The combined use of the TyG index and other independent risk factors (age, sex, smoking status, family history and FOBT) to distinguish CRN was effective, with a sensitivity of 61.0%, a specificity of 65.1% and an AUC of 0.669 (95%CI, 0.639 - 0.698). Likewise, the combined use of the AIP and other independent risk factors to distinguish CRN was also effective, the model had an overall 56.3% sensitivity and 68.7% specificity with an AUC of 0.667 (95%CI, 0.638 - 0.697).ConclusionThis study showed that the TyG index and the AIP might be biomarkers that could be used to predict the risk of CRN in patients without CVD.

show abstract

Association of the atherogenic index of plasma with cardiovascular risk beyond the traditional risk factors: a nationwide population-based cohort study

Cited by 75 publications

References 28 publications

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Intake of Low Glycaemic Index Foods but Not Probiotics Is Associated with Atherosclerosis Risk in Women with Polycystic Ovary Syndrome

Triglyceride glucose index and Atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases

Contact Info

Product

Resources

About