2013
DOI: 10.1007/s12020-013-0020-1
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Association of the ATM gene polymorphisms with papillary thyroid cancer

Abstract: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, yet few genetic markers of PTC risk useful for screening exist. Our study aimed to evaluate the association between single nucleotide polymorphisms (SNPs) of the ataxia telangiectasia mutated (ATM) gene and PTC risk. 358 patients with PTC and 360 healthy controls were included in the case-control study. Four ATM SNPs (rs664677, rs373759, rs4988099, and rs189037) were genotyped by matrix-assisted laser desorption/ionization time of flight… Show more

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Cited by 32 publications
(33 citation statements)
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“…However, this cohort of subjects belonged to the Han population in northern China, so their living conditions, traditions, customs, lifestyle, and some other demographic characteristics are unique; these demographic characteristics would be different in people belonging to other races. For example, most food preparations of the Han Chinese population contain excessive salt (Gu et al, 2014). Thus, these demographic characteristics of the Han Chinese population could be considered as a limitation of our study.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…However, this cohort of subjects belonged to the Han population in northern China, so their living conditions, traditions, customs, lifestyle, and some other demographic characteristics are unique; these demographic characteristics would be different in people belonging to other races. For example, most food preparations of the Han Chinese population contain excessive salt (Gu et al, 2014). Thus, these demographic characteristics of the Han Chinese population could be considered as a limitation of our study.…”
Section: Discussionmentioning
confidence: 97%
“…SNP genotyping reactions were performed in a 384-well Spectro-CHIP using a MassARRAY nanodispenser (Sequenom, Inc.). HotStar Taq was used in PCR (Gu et al, 2014). PCR amplification conditions were set for an initial cycle of 15 min at 94°C, and then the following different cycles were conducted: 45 cycles at 94°C for 20 s, 56°C for 30 s, 72°C for 60 s, and finally 72°C for 10 s. PCR products were subjected to the shrimp alkaline phosphatase reaction and single-base extension.…”
Section: Study Populationmentioning
confidence: 99%
“…A-T cells are characterized by an extreme sensitivity of DNA to radiomimetic agents because of alteration of cell-cycle inhibition in response to radiation exposure. ATM gene polymorphisms can be a risk factor for thyroid carcinomas (8). First relatives of A-T patients can also develop solid tumors such as breast carcinomas.…”
Section: Discussionmentioning
confidence: 99%
“…Missense mutations and polymorphisms of ATM gene can play a role in the development thyroid papillary carcinoma [5][6][7][8][9] . Both DNA double-strand break repair pathway and thyroid morphogenesis pathway or dysregulation of thyroid differentiated state maintenance are involved in the etiology of papillary thyroid carcinoma 10 .…”
mentioning
confidence: 99%
“…In our previous case-control study, we did not find significant tendency of risk alleles increasing from healthy controls to nonmetastatic PTCs, to metastatic PTCs using the trend chi-square test [38], while gender is an important factor in PTC because the incidence rate between males and females is distinct, so it is necessary to treat gender-specific PTC separately. In this stratification analysis, we demonstrated possible relevance of polymorphism in ATM rs189037 to metastatic risk of PTC in females though it became insignificant after Bonferroni correction.…”
Section: Discussionmentioning
confidence: 99%