2001
DOI: 10.1093/aje/153.7.688
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Association of the B-Vitamins Pyridoxal 5′-Phosphate (B6), B12, and Folate with Lung Cancer Risk in Older Men

Abstract: A nested case-control study was conducted within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort to test for associations between selected B-vitamins (folate, vitamin B(6), vitamin B(12)) and incident lung cancer. This trial was conducted in Finland between 1985 and 1993. Serum was analyzed for these nutrients and homocysteine among 300 lung cancer cases and matched controls (1:1). Odds ratios and 95% confidence intervals were determined in conditional and unconditional (controlling for the … Show more

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Cited by 86 publications
(86 citation statements)
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“…In Finland and Italy, Hcy concentration varied greatly. The higher Hcy concentration in the Finnish ATBC study was because the cohort consisted of male smokers (Hartman et al, 2001). The highest Hcy concentrations, close to 15 mmol l…”
Section: Status Of Folate Vitamin B12 and Homocysteinementioning
confidence: 79%
“…In Finland and Italy, Hcy concentration varied greatly. The higher Hcy concentration in the Finnish ATBC study was because the cohort consisted of male smokers (Hartman et al, 2001). The highest Hcy concentrations, close to 15 mmol l…”
Section: Status Of Folate Vitamin B12 and Homocysteinementioning
confidence: 79%
“…One significant factor is the Japanese diet with its low fat intake and high intake of several phytochemicals (isoflavones, tea catechines, folate or isothiocyanates). 37,[42][43][44][45] Moreover, indoor radon concentration is relatively low in Japan, 46 which may also contribute to a lower relative risk associated with smoking.…”
Section: Discussionmentioning
confidence: 99%
“…The OR for the highest quintile of plasma PLP (>48.2 nmol/l) versus the lowest quintile of plasma PLP (≤20.6 nmol/l) was 0.51 (95% CI 0.28-0.93; P trend =0.02) (Hartman et al 2001). After stratification for smoking, alcohol, methionine intake, serum B12, serum folate, and serum homocysteine, a significant inverse association was found only in smokers (>40 years), subjects with low methionine intake levels (≤ 1.990 mg/day), and subjects with low serum vitamin B12 levels (≤451.7 pg/ml).…”
Section: Lung Cancermentioning
confidence: 95%
“…Risk of bias in exposure assessment; high correlation between micronutrients in the diet (Chuang et al 2011, de Bree et al 2003, Eussen et al 2010a, Eussen et al 2010b, Folsom et al 1998, Hartman et al 2001, He et al 2004, Johansson et al 2010, Key et al 2012, Lin et al 2008, Page et al 2009.…”
Section: Nested Case Control Studiesmentioning
confidence: 99%