Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population

Khedri, Azam; Nejatshokouhi, A.; Salek, Roham; Esmaeili, Habibollah; Mokhtarifar, Ali; Heravi, Reza Entezari; Tatari, Farnoosh; Behravan, Javad; Miladpour, Behnoosh; Tehrani, Shahireh Omidvar

doi:10.1007/s11033-010-9957-9

Cited by 24 publications

(12 citation statements)

References 17 publications

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“…This was inconsistent with most other studies [13][14][15][16][17][18][19][20][21][22]. In this meta-analysis the results when stratified for ethnicity or population source, indicated no association between ABCB1 rs1045642 SNPs and CRC.…”

Section: Discussioncontrasting

confidence: 98%

ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

Zhang

et al. 2011

Colorectal Disease

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Aim: ABCB1/MDR1 is found in high concentrations on the apical surfaces of colonic epithelial cells. It acts as an efflux pump by transporting toxic endogenous substances, drugs and xenobiotics out of cells. ABCB1/MDR1 polymorphisms may either change its protein expression or alter its function, suggesting a possible association between ABCB1/MDR1 single nucleotide polymorphisms (SNP) and colorectal cancer. Several studies have reported the relationship between ABCB1 gene polymorphism and colorectal cancer (CRC) risk, but no consistent conclusion has been arrived at. We therefore conducted a meta-analysis to identify any association between ABCB1 gene and CRC risk.Method: PubMed, Embase, Google Scholar, Cbmdisc and CNKI were searched for studies on the relationship of ABCB1/MDR1 SNPs and the incidence of CRC. Eligible articles were included for data extraction. The main outcome was the frequency of ABCB1/MDR1 SNPs among cases and controls. Comparison of the distribution of SNP was mainly performed using Review Manager 5.0.Results: There were ten, four and two trials focusing on ABCB1 rs1045642, rs2032582 and rs3789243 SNP respectively. A total of 3175 cases and 3715 controls were included. The meta-analysis, stratified by ethnicity or population source, indicated no association between ABCB1 rs1045642 polymorphism and CRC risk . However, when the study by Bae et al was removed from the analysis, there was some evidence to indicate a higher frequency of T allele in CRC patients among Asians (OR= 1.30, 95%CI 1.02-1.67,P=0.03). Neither ABCB1 rs2032582 nor rs3789243 indicated an association with CRC risk. An increased frequency of only wild-type combined allele (rs2032582G/ rs1045642C) was found in Caucasian patients (OR= 1.22, 95%CI 1.03-1.44, P=0.02). Conclusion:There is some evidence to indicate an association of ABCB1 rs1045642T and CRC risk in Asians. Compared with SNPs for ABCB1 rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to CRC among Caucasians.

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Section: Discussioncontrasting

confidence: 98%

ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

Zhang

et al. 2011

Colorectal Disease

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“…In agreement with our results, Andersen and co-workers found that carriers of C allele of the C3435T polymorphism had an increased risk of CRC in Norwegian Caucasian population (Andersen et al, 2009). On the contrary, in an Iran population investigation, T allele of the ABCB1 C3435T polymorphism showed significantly increased risk of CRC (Khedri et al, 2011), while others did not find any statistically significant associations (Bae et al, 2006;Samanian et al, 2011). Regarding ABCB1 G2677T/A genotypes and risk for CRC, we did not find any correlation between CRC risk and the investigated G2677T/A genotypes, likewise, De Iudicibus et al found no relation between ABCB1 G2677T/A polymorphism and CRC patients (De Iudicibus et al, 2008).These data suggest that the role of the ABCB1 polymorphisms in cancer risk may vary with ethnicity, a possibility that warrants further investigation.…”

Section: Discussionsupporting

confidence: 90%

Associations of ABCB1 and XPC Genetic Polymorphisms with Susceptibility to Colorectal Cancer and Therapeutic Prognosis in a Chinese Population

Yue

Xie²,

Zhao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Associations between ABCB1 and XPC genetic polymorphisms and risk of developing colorectal cancer (CRC) as well as clinical outcomes in CRCs with chemotherapy were investigated. A case-control study was performed on the ABCB1 C3435T, G2677T/A and XPC Lys939Gln polymorphisms in 428 CRC cases and 450 hospitalbased, age and sex frequency-matched controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. We observed that the ABCB1 3435CT or CC+CT variants were significantly linked with increasing risk of developing CRC (adjusted OR (95% CI): 1.814 (1.237-2.660), P=0.0022; adjusted OR (95% CI): 1.605 (1.117-2.306), P=0.0102, respectively). Moreover, the distribution frequency of XPC AC genotype or AC+CC genotypes also showed a tendency towards increasing the suscepbility for CRC (P=0.0759 and P=0.0903, respectively). Kaplan-Meier curves showed that the ABCB1 C3435T variant was associated with a tendency toward longer progression-free survival (PFS) (n=343, Log-rank test: P=0.063), and the G2677T/A variant genotypes (GT+TT+GA+AA) with a tendency for longer OS in postoperative oxaliplatin-based patients (n=343, Log-rank test: P=0.082). However, no correlation of the XPC Lys939Gln polymorphism was found with PFS and OS in patients with postoperative oxaliplatin-based chemotherapy (n=343). Our study indicated that ABCB1 polymorphisms might be candidate pharmacogenomic factors for the prediction of CRC susceptibility, but not for prognosis with oxaliplatin chemosensitivity in CRC patients.

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“…Overall these studies are heterogeneous in terms of size, number of SNPs tested, methodology used and ethnicity. C3435T was found to be associated with disease risk in several case-control studies [33], [57], [58], [59] while others did not find any statistically significant associations [34], [60] The polymorphism variant 2677G>T/A (rs2032582) in exon 21 has also been found associated with CRC risk [26], [45], [59], although not in all studies [34]. Anderson and colleagues also tested the possible association of rs3789243 in two distinct studies.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer

et al. 2012

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ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. A hybrid tagging/functional approach was performed to select 28 single nucleotide polymorphisms (SNPs) that were genotyped in 1,321 Czech subjects, 699 CRC cases and 622 controls. In addition, six potentially functional SNPs were genotyped in 3,662 German subjects, 1,809 cases and 1,853 controls from the DACHS study. We found that three functional SNPs (rs1202168, rs1045642 and rs868755) were associated with CRC risk in the German population. Carriers of the rs1202168_T and rs868755_T alleles had an increased risk for CRC (Ptrend = 0.016 and 0.029, respectively), while individuals bearing the rs1045642_C allele showed a decreased risk of CRC (Ptrend = 0.022). We sought to replicate the most significant results in an independent case-control study of 3,803 subjects, 2,169 cases and 1,634 controls carried out in the North of Germany. None of the SNPs tested were significantly associated with CRC risk in the replication study. In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC.

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Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population

Cited by 24 publications

References 17 publications

ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

ABCB1/MDR1 polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

Associations of ABCB1 and XPC Genetic Polymorphisms with Susceptibility to Colorectal Cancer and Therapeutic Prognosis in a Chinese Population

A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer

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