Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population

Binh, Tran Quang; Phương, Phạm Trần; Nhung, Bùi Thị; Thoang, Dang Dinh; Lien, Ha Thi; Thanh, Duong Van

doi:10.1016/j.gene.2012.10.082

Cited by 33 publications

(22 citation statements)

References 29 publications

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“…In European eutrophic populations, the frequency of the AA genotype is approximately 14% (10, 11), whereas in Vietnamese populations, the frequency of the AA genotype is less than 2% (12). In overweight Japanese populations, the frequency of the AA and AT genotypes were found to be approximately 8 and 35%, respectively (13,14).…”

Section: Introductionmentioning

confidence: 99%

A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery

et al. 2015

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Section: Introductionmentioning

confidence: 99%

A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery

et al. 2015

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“…FTO transcript expression has been detected in all of the tissues tested, and is the highest in the brain (McTaggart et al, 2011;Xing et al, 2013), which plays an important role in regulating feed intake and energy expenditure, commensurate with perceived whole-body energy requirements (Richards and Proszkowiec-Weglarz, 2007). In humans, several single nucleotide polymorphisms (SNPs) of FTO that are associated with the body mass index (BMI) have been found, which contribute to obesity and related diseases (Hubacek et al, 2010;Binh et al, 2013). Jia et al (2012) reported that in chickens, FTO is related to glucose metabolism, body weight (BW), and fat content.…”

Section: Introductionmentioning

confidence: 99%

Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks

et al. 2015

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ABSTRACT. The fat mass and obesity-associated gene (FTO) is an excellent candidate gene that affects energy metabolism. Single nucleotide polymorphisms (SNPs) in FTO are associated with carcass and meat quality traits in pigs, cattle, and rabbits. The aim of this study was to investigate the association between novel SNPs in the FTO coding region and carcass and meat quality traits in 95 crossbred ducks, using DNA sequencing. We found two transitions G/A (SNP 387 and 473) within exon 3. SNP 387 was a synonymous mutation, whereas SNP 473 was a missense mutation. Association analysis suggested that SNP g.387G>A was significantly associated with all of the carcass traits measured, the intramuscular fat content (IMF), cooking yield (CY), pH values 45 min after slaughter (pH45m), drip losses from the breast muscle, and the leg muscle (P < 0.05). For SNP g.473G>A, the genotype AA exhibited greater leg muscle weight than the genotypes GG or AG (P < 0.05). The D value suggested that the two SNPs exhibited strong linkage disequilibrium. Three haplotypes (G 1 G 2 , G 1 A 2 , and A 1 A 2 ) were significantly associated with IMF, CY, the a* value, and all of the carcass traits measured (P < 0.05). The results suggest W. Gan et al. 6700©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6699-6714 (2015) that FTO is a candidate locus that affects carcass and meat quality traits in ducks.

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“…A study conducted in Vietnam reported that the FTO genetic variants are associated with T2DM even after adjustment for age, sex, systolic blood pressure, socioeconomic status, lifestyle factors and obesity-related traits. As per the study, the risk associated with each risk allele of rs 9939609, was 1.80-1.92 (43). The variants of RAGE and PAI-1 genes have been shown to be linked with micro-and macro-vascular complications in Caucasians (44,45).…”

Section: Genetics Of Type 2 Diabetes In South Asian Populationmentioning

confidence: 68%

Genetics of Type 2 Diabetes Mellitus-Asian Perspective (A Review)

Fawwad¹,

Rashid²,

Basit³

2017

Turk J Endocrinol Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has come up as a major cause of mortality and continues to cause enormous socio-economic loss across the globe. In the purview of this, a thorough understanding of the pathophysiology, etiology, and pathogenesis of the condition is the need-of-the-hour so as to develop potent therapeutics to have a better control of T2DM. In the developing countries, especially the South Asian region, the condition has become a major health issue owing to the low income and distinct socio-economic patterns. In the European population, a variety of genes have been found to be associated with T2DM; however, their contribution to the other ethnic groups is still unclear. In recent years, various research groups analyzed the prevalence of such genes in Asian populations. The Genome Wide Association Scan (GWAS) successfully identied more than 70 genetic variants that are associated with the T2DM. The present article intends to provide a comprehensive account of the major studies on the genetics of T2DM, with special reference to the Asian population. The various risk factors and the complications associated with the T2DM will be discussed. The review also highlights the major differences and similarities between the susceptibility loci that have been investigated in different ethnicities to provide a novel insight into the disease pathogenesis and its heritability patterns. The information presented, herein, on the genetics of type 2 Diabetes Mellitus holds signicance as it paves the way for the development of potential biomarkers and strengthens the fact that specic genetic alterations have important functional roles in the progression or development of T2DM. Keywords: Diabetes; genetics; genome-wide association scan Tip 2 diabetes mellitus (T2DM), dünya genelinde mortalitenin majör nedeni olan bir metabolik bozukluktur. Hastalığın patozyolojisini, etiyolojisini ve patogenezini daha iyi anlamak için, uygun şekilde odaklanmış terapötik ve araştırma çabaları gereklidir; çünkü hastalığın prevalansı dünya genelinde yaşamları ve ekonomileri etkilemektedir. Gelişmekte olan ülkelerde özellikle Güney Asya bölgesinde, düşük gelir ve farklı sosyoekonomik paternlere bağlı olarak merkezi bir sağlık yükü olmaya başlamaktadır. Avrupalılar arasında gen çeşitliliği T2DM ile ilişkilidir, fakat bu genetik varyantların diğer etnik gruplardaki katkıları hâlâ açık değildir. Asyalılarda yapılan çeşitli yeni çalışmalar bu genlerin bazılarını çoğaltmıştır. "Genom Wide Association Scan (GWAS)", T2DM ile ilişkili 70'ten fazla genetik varyantı başarılı bir şekilde tanımlamıştır. Metodoloji, özellikle Asya ülkelerinde T2DM'nin genetiğiyle ilişkili literatür araştırmasını içermiştir. Bu gözden geçirme T2DM, risk faktörleri ve komplikasyonlarıyla ilişkili majör genetik tabanlı çalışmaların kısa bir özetidir. Ayrıca, farklı etnisitelerde araştırılan duyarlılık loküsünun majör faklılıklarını ve benzerliklerini vurgulamaktadır ki bu da patogenez ve kalıtım mekanizmalarına yeni bir bakış açısı sağ-lama...

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Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population

Cited by 33 publications

References 29 publications

A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery

A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery

Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks

Genetics of Type 2 Diabetes Mellitus-Asian Perspective (A Review)

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