Association of the expression of p53 and p16INK4A with the clinical and morphological characteristicsof patients with head and neck squamous cell cancer

Stukan, А. I.; Chukhray, O. Yu.; Pоrkhanov, V. A.; Bodnya, V. N.

doi:10.17116/patol20198103112

Cited by 2 publications

(2 citation statements)

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“…We identified a greater association of grade 0 staining of proteins in the tongue and/or floor of the mouth (p = 0.0431), which may suggest less mutagenic potential in carcinogenesis, as there was a trend towards earlier stages, less lymphatic dissemination or relapses, and better survival (Table 5) [20,38,51].…”

Section: Discussionmentioning

confidence: 99%

“…Despite some limitations such as absence of genetic sequencing of p53 and p16 proteins, non-identification of HPV16, and small sample size, both p53 and p16 proteins were shown to be potential biomarkers [49][50][51][52]. The p53 protein appeared to show a decrease in its suppressive activity, whereas the p16 protein, in grades 2 and 3, acquired a regulatory role in cell proliferation, improving the prognosis [49,50,52].…”

Section: Discussionmentioning

confidence: 99%

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P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

C Vidal

2024

OJOR

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

C Vidal

2024

OJOR

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Analysis of the Correlation Between Papillomavirus Infection and the Expression of Tumor Suppressor Proteins in Patients With Oral Epithelial Dysplasia

Stepanov,

Hisamieva,

Tarasenko

et al. 2024

Actual Problems in Dentistry

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Data from domestic and foreign literature indicate a close pathogenetic relationship between the expression of cancer markers p16 and p53, tumor suppressor proteins, and the invasion of human papillomavirus (HPV) in patients with precancerous lesions of the oral mucosa. Thus, it seems advisable to evaluate the frequency of detection of the expression of cancer markers p16 and p53 by immunohistochemical examination in patients with HPV-positive and HPV-negative dysplastic lesions of the oral mucosa. The aim is to increase the effectiveness of the diagnosis of lesions of the oral mucosa associated with epithelial dysplasia. Materials and methods. The study involved 50 patients with established diagnoses of leukoplakia and lichen planus with signs of epithelial dysplasia. After surgery, all patients underwent an immunohistochemical study of the expression of proteins p16 and p53 and a PCR study for papillomavirus. The ratio of the frequency of detection of cancer marker expression in subgroups depending on the HPV status was evaluated. Results. There were no statistically significant differences in the frequency of detection of p53 (p = 0.161) and p16 (p = 0.21) cancer marker expressions depending on the HPV status of patients. There were also statistically insignificant differences in the frequency of detection of the expression of cancer markers p16 (p = 0.333) and p53 (p = 0.178) depending on gender. The HPV-positive status of patients with epithelial dysplasia of the oral mucosa was statistically significantly more often associated with the female sex (p = 0.008). Conclusion. The assessment of the expression of proteins p16 and p53 is not a reliable method for diagnosing oral epithelial dysplasia and associated papillomavirus infection. There is a need to search for alternative and more accurate molecular markers of the disease, as well as a greater number of observations.

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Association of the expression of p53 and p16INK4A with the clinical and morphological characteristicsof patients with head and neck squamous cell cancer

Cited by 2 publications

References 9 publications

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

Analysis of the Correlation Between Papillomavirus Infection and the Expression of Tumor Suppressor Proteins in Patients With Oral Epithelial Dysplasia

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