Association of the Frequency and Quantity of Alcohol Consumption With Gastrointestinal Cancer

Yoo, Jung Eun; Shin, Dong Wook; Han, Kyungdo; Kim, Dahye; Jeong, Su‐Min; Koo, Hye Yeon; Yu, Su Jong; Park, Jinsung; Choi, Kui Son

doi:10.1001/jamanetworkopen.2021.20382

Cited by 45 publications

(38 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although these findings are similar to our results, they provide evidence for cancers other than GC. In terms of drinking patterns, only one study's results are concordant with our findings 29 . This latest Korean research further indicates that the frequency of alcohol intake, rather than quantity, is a more important risk factor for gastrointestinal (GI) cancers including GC 29 .…”

Section: Discussionsupporting

confidence: 86%

“…In terms of drinking patterns, only one study's results are concordant with our findings 29 . This latest Korean research further indicates that the frequency of alcohol intake, rather than quantity, is a more important risk factor for gastrointestinal (GI) cancers including GC 29 . Nonetheless, further research is warranted to thoroughly explore and evaluate alcohol drinking patterns and GC risk.…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study

Lee

Huang

Shin

et al. 2022

Cancer Biology & Medicine

View full text Add to dashboard Cite

Objective: Epidemiological studies indicate that alcohol increases gastric cancer (GC) risk, yet most studies have focused on heavy alcohol intake, leaving other factors understudied. A comprehensive investigation of the effects of the frequency and amount of alcohol intake may help elucidate the GC risk associated with drinking behavior. Methods: The Health Examinees-Gem (HEXA-G) study, a community-based large-scale prospective cohort study, enrolled Korean adults 40–69 years of age between the years 2004 and 2013. Incident GC cases were identified through linkage to Korea Central Cancer Registry data until December 31, 2017. Self-reported questionnaires were used to survey alcohol consumption-related factors (duration, frequency, amount, and type of alcoholic beverages). The frequency and amount of alcohol consumption were combined to explore GC risk according to 4 drinking patterns: “infrequent-light”, “frequent-light”, “infrequent-heavy”, and “frequent-heavy”. We used Cox proportional hazard models to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs), and investigate the relationship between alcohol intake and GC incidence. Results: A total of 128,218 participants were included in the analysis. During an average follow-up period of 8.6 years, 462 men and 385 women were diagnosed with GC. In men, current drinkers showed a 31% greater risk of GC than non-drinkers (HR 1.31, 95% CI 1.03–1.66), whereas no significant association was observed in women. In men, GC risk was associated with a higher frequency (P trend 0.02) and dose of ethanol intake in grams (P trend 0.03). In men, the “frequent-light” (≥5 times/week and <40 g ethanol/day) drinking pattern was associated with a 46% greater risk of GC (HR 1.46, 95% CI 1.02–2.07) than the “infrequent-light” pattern (<5 times/week and <40 g ethanol/day). Conclusions: This study suggests that frequent intake of alcohol, even in low quantities per session, increases GC risk. Further research is warranted to evaluate the relationship between alcohol and GC in detail.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study

Lee

Huang

Shin

et al. 2022

Cancer Biology & Medicine

View full text Add to dashboard Cite

show abstract

“…Based on a meta-analysis describing 22 cohort studies (5,820,431 cases), light or moderate alcohol consumption had no significant effect in the pathogenesis of GC, but heavy alcohol consumption (> 24 g / per day) increased cancer risk independently to gender, country of origin, or physical activity [47]. Similar conclusions have been drawn from other studies regarding the severity of alcohol consumption [48][49][50][51][52][53][54].…”

Section: Alcohol Consumptionsupporting

confidence: 58%

Helicobacter pylori cytotoxin-associated gene A virulence and its association with the epithelial-mesenchymal transition in gastric cancer

Dudek¹,

Forma

Hamerska

et al. 2022

J Educ Health Sport

View full text Add to dashboard Cite

Gastric cancer is currently one of the most prevalent malignancies worldwide with a high mortality rate. Helicobacter pylori (H. pylori) infection significantly contributes to the onset and progression of gastric cancer mainly due to the induction of chronic inflammatory responses. The pathogenicity of H. pylori is associated with a vast number of virulence factors among which cytotoxin-associated gene A (CagA) plays a crucial role. We conducted a literature review of PubMed, Web of Science, and Scopus on September 1st, 2021. There were no limits regarding the year and the language of publication. Articles included in this review concerned human and animal studies. The following search string was applied during the search: (gastric cancer) AND (epithelial-mesenchymal transition) AND (Helicobacter pylori) AND (cytotoxin-associated gene A). The final analysis included 135 articles independently reviewed by the authors. H. pylori CagA-positive strains seem to be more virulent compared to the CagA-negative strains. CagA pathogenicity includes the increased secretion of pro-inflammatory cytokines, induction of cancer stem cell-like properties, apoptosis prevention, or overactivation of particular oncogenic pathways. H. pylori might induce epithelial-mesenchymal transition (EMT) via numerous pathways, among which CagA-related pathogenicity is considered to be of high significance. Mechanisms associated with CagA action are involved in the maintenance of chronic H. pylori infection, subsequent EMT induction, and further onset and progression of gastric cancer. Because of a huge number of H. pylori strains with different virulence mechanisms, the clinical outcome of patients is also associated with the particular type of strain that infected a patient.

show abstract

“…Because enrollment in this co-payment reduction program is indicated by a special co-payment reduction code for cancer (V193) and requires a medical certificate from a physician, the cancer diagnoses included in this study are considered to be sufficiently reliable, and this method has been used in previous studies. 18,19 We considered socioeconomic position, including income level and place of residence (urban or rural), to be a potential covariate. Household income was categorized into quartiles according to insurance premium levels, and those covered by the Medical Aid Program (the poorest 3% of the Korean population) were merged into the lowest income quartile.…”

Section: Discussionmentioning

confidence: 99%

Association Between Changes in Alcohol Consumption and Cancer Risk

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Association of the Frequency and Quantity of Alcohol Consumption With Gastrointestinal Cancer

Cited by 45 publications

References 42 publications

Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study

Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study

Helicobacter pylori cytotoxin-associated gene A virulence and its association with the epithelial-mesenchymal transition in gastric cancer

Association Between Changes in Alcohol Consumption and Cancer Risk

Contact Info

Product

Resources

About