Association of the gut microbiota with clinical variables in obese and lean Emirati subjects

Ahmad, Manal Ali; Karavetian, Mirey; Moubareck, Carole Ayoub; Wazz, Gabi; Mahdy, Tarek; Venema, Koen

doi:10.3389/fmicb.2023.1182460

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…It is important to note that Erysipelotrichales and Verrucomicrobiota have been shown to associate with metabolic dysregulation including HFD-induced obesity and inflammation. [47,48] These results further demonstrate the significant impacts of broccoli GRN in modulating favorable microbiome composition from phylum to genus levels.…”

Section: Grn Influenced Intestinal Flora Composition and Structurementioning

confidence: 55%

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface

Bankole,

Ma,

Arora

et al. 2024

Molecular Nutrition Food Res

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ScopeObesity and its metabolic comorbidities pose a major global challenge for public health. Glucoraphanin (GRN) is a natural bioactive compound enriched in broccoli that is known to have potential health benefits against various human chronic diseases.Methods and resultsThis study investigats the effects of broccoli GRN supplementation on body weight, metabolic parameters, gut microbiome and metabolome associated with obesity. The study is conducted on an obese‐related C57BL/6J mouse model through the treatment of normal control diet, high‐fat diet (HFD)and GRN‐supplemented HFD (HFD‐GRN) to determine the metabolic protection of GRN. The results shows that GRN treatment alleviates obesity‐related traits leading to improved glucose metabolism in HFD‐fed animals. Mechanically, the study noticed that GRN significantly shifts the gut microbial diversity and composition to an eubiosis status. GRN supplement also significantly alters plasma metabolite profiles. Further integrated analysis reveal a complex interaction between the gut microbes and host metabolism that may contribute to GRN‐induced beneficial effects against HFD.ConclusionThese results indicate that beneficial effects of broccoli GRN on reversing HFD‐induced adverse metabolic parameters may be attributed to its impacts on reprogramming microbial community and metabolites. Identification of the mechanistic functions of GRN further warrants it as a dietary candidate for obesity prevention.

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Section: Grn Influenced Intestinal Flora Composition and Structurementioning

confidence: 55%

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface

Bankole,

Ma,

Arora

et al. 2024

Molecular Nutrition Food Res

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show abstract

“…In addition, the increase in Parasutterella , from the Proteobacteria phylum, in obesity-prone mice is highly linked to the development of obesity [ 19 ], and obesity-resistant rats had significantly higher relative abundances of the genus Clostridium , from the Firmicutes phylum, and the genus Akkermansia , from the Verrucomicrobia phylum [ 20 ]. Moreover, humans with obesity had higher abundances of Verrucomicrobia , Acidaminococcus , Lachnospira and Saccharibacteira and lower abundances of Lentisphaerae [ 21 ]. Additionally, a previous publication stated that humans with overweight or obesity had a higher abundance of Akkermansia muciniphila , which was correlated with a healthier metabolic status [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Distinct Gut Microbiota and Arachidonic Acid Metabolism in Obesity-Prone and Obesity-Resistant Mice with a High-Fat Diet

Zhang,

Chen,

Yang

et al. 2024

Nutrients

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An imbalance of energy intake and expenditure is commonly considered as the fundamental cause of obesity. However, individual variations in susceptibility to obesity do indeed exist in both humans and animals, even among those with the same living environments and dietary intakes. To further explore the potential influencing factors of these individual variations, male C57BL/6J mice were used for the development of obesity-prone and obesity-resistant mice models and were fed high-fat diets for 16 weeks. Compared to the obesity-prone mice, the obesity-resistant group showed a lower body weight, liver weight, adipose accumulation and pro-inflammatory cytokine levels. 16S rRNA sequencing, which was conducted for fecal microbiota analysis, found that the fecal microbiome’s structural composition and biodiversity had changed in the two groups. The genera Allobaculumbiota, SMB53, Desulfovibrio and Clostridium increased in the obesity-prone mice, and the genera Streptococcus, Odoribacter and Leuconostoc were enriched in the obesity-resistant mice. Using widely targeted metabolomics analysis, 166 differential metabolites were found, especially those products involved in arachidonic acid (AA) metabolism, which were significantly reduced in the obesity-resistant mice. Moreover, KEGG pathway analysis exhibited that AA metabolism was the most enriched pathway. Significantly altered bacteria and obesity-related parameters, as well as AA metabolites, exhibited strong correlations. Overall, the phenotypes of the obesity-prone and obesity-resistant mice were linked to gut microbiota and AA metabolism, providing new insight for developing an in-depth understanding of the driving force of obesity resistance and a scientific reference for the targeted prevention and treatment of obesity.

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Association between Gut Microbiota Profiles, Dietary Intake, and Inflammatory Markers in Overweight and Obese Women

Chansa,

Shantavasinkul,

Monsuwan

et al. 2024

Foods

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Being overweight and obesity are significant global public health challenges due to their association with adipose tissue dysfunction, pro-inflammatory marker production, and alterations in gut microbiota composition. To explore the relationship between gut microbiota, dietary factors, and inflammatory markers in overweight or obese women, we conducted a cross-sectional study involving a healthy group (n = 20) and an overweight or obese group (n = 75). We collected data, including clinical, anthropometric, and dietary assessments, and carried out a blood biochemical analysis, the measurement of inflammatory biomarkers (hs-CRP, IL-6, and TNF-α), and the 16S rRNA gene sequencing of fecal samples. The gut microbiota analysis revealed notable differences in alpha and beta diversity between the two groups. Moreover, the abundance of gut microbiota in the overweight or obese group correlated positively with adiposity markers, blood pressure, lipid profiles, and inflammatory markers. These findings highlight significant changes in gut microbiota associated with obesity, potentially implicating pathways such as lipopolysaccharide biosynthesis. Understanding the role of the gut microbiome in obesity could reveal specific avenues for intervention.

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Association of the gut microbiota with clinical variables in obese and lean Emirati subjects

Cited by 3 publications

References 60 publications

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface

Distinct Gut Microbiota and Arachidonic Acid Metabolism in Obesity-Prone and Obesity-Resistant Mice with a High-Fat Diet

Association between Gut Microbiota Profiles, Dietary Intake, and Inflammatory Markers in Overweight and Obese Women

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