Association of the human platelet antigens polymorphisms with platelet count in patients with COVID-19

Ghaffari, Kazem; Rad, Mahsa Ashrafi; Moradi Hasan-Abad, Amin; Khosravi, Mersedeh; Benvidi, Arefeh; Iraji, Mahsa; Khargh, Heidar Ali Heidari; Ghasemi, Ali

doi:10.3389/fmed.2023.1265568

Cited by 2 publications

(2 citation statements)

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“…All these factors may affect PLT parameters, including MPV levels (Harrison and Goodall, 2016). Among the differences in the clinical conditions of the patients, we can mention the deficiency or decrease in the level of vitamin D in the patients, gender, and HPA polymorphisms (Gur et al, 2015;Alanli et al, 2020;Ghaffari et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D deficiency on platelet parameters in patients with COVID-19

Talebzadeh,

Ghaffari,

Ghaffari

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionSince there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value of these parameters in cases of vitamin D deficiency.MethodsSeven hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. Patients were divided into two groups: those with and without vitamin D deficiency. The associations between platelet indices and vitamin D levels were analyzed by Pearson’s correlation analysis and a one-way ANOVA test.ResultsPlatelet count and mean platelet volume (MPV) were significantly higher in the patients with vitamin D deficiency than in the patients without vitamin D deficiency. There was a significant negative correlation between platelet count and MPV with vitamin D levels in patients with vitamin D deficiency (r = -0.835, P = 0.001 & r = -0.324, P = 0.042, respectively). Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the patients.DiscussionThe aforementioned results imply that maintaining an elevated concentration of vitamin D in COVID-19 patients is important because it is associated with a decrease in MPV, which in turn reduces susceptibility to diseases such as coronary artery disease.

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Section: Discussionmentioning

confidence: 99%

The effect of vitamin D deficiency on platelet parameters in patients with COVID-19

Talebzadeh,

Ghaffari,

Ghaffari

et al. 2024

Front. Cell. Infect. Microbiol.

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“…To date, 41 human platelet antigens (HPAs) have been described in the Immuno Polymorphism Database (IPD) 1 ( 3 ). Several types of HPAs are involved in different clinical conditions, including venous thrombosis ( 4 ), myocardial infarction ( 5 ), post-transfusion purpura (PTP), platelet (PLT) transfusion refractoriness, alloimmune thrombocytopenia, idiopathic thrombocytopenic purpura (ITP) ( 6 , 7 ), drug-induced immune thrombocytopenia (DITP), fetal/neonatal alloimmune thrombocytopenia (FNAIT) ( 8 , 9 ), and susceptibility to HCV infection ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

PLT antigen discrepancy pattern among couples with recurrent abortion

Shad,

Ghasemi,

Zadsar

et al. 2024

Front. Med.

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BackgroundRecurrent abortion refers to a condition of two or more consecutive pregnancies without known etiology affected by miscarriage before the completion of the 20th week of gestational age. However, several hypotheses have been proposed, but not much data are available concerning the relationship between human platelet antigens (HPAs) polymorphisms and recurrent abortion. This study was conducted to evaluate the genetic differences between HPA-1, −2, −3, −5, and − 15 in Iranian couples with a history of recurrent abortion.MethodsIn this cross-sectional study, a total of 74 couples with at least 2 recurrent abortions without any known specified reasons enrolled in the study. HPA polymorphisms genotyping was performed by single-specific primer PCR. Genotype frequency was calculated using the Hardy–Weinberg equation.ResultsA total of 39 couples (52.7%) had HPA genotyping partial mismatches. The most common partial mismatch pairs were found concomitantly on both HPA-15a and HPA-15b in three couples (4%), followed by two (2.7%) on HPA-3a and one (1.3%) in each HPA-2b and HPA-5b. There was a deviation from the Hardy–Weinberg equilibrium in the HPA-2 and -5 systems.ConclusionThe present study declared that partial mismatches of HPA-3 and -15 genotypes were common among Iranian couples due to the history of recurrent abortion and approximately half of the couples carried at least one HPA gene that was absent in their partners. Further studies might be helpful to clarify the association between HPA polymorphisms and recurrent abortion, such as an investigation into the alloantibodies against HPAs.

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Association of the human platelet antigens polymorphisms with platelet count in patients with COVID-19

Cited by 2 publications

References 40 publications

The effect of vitamin D deficiency on platelet parameters in patients with COVID-19

The effect of vitamin D deficiency on platelet parameters in patients with COVID-19

PLT antigen discrepancy pattern among couples with recurrent abortion

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