Association of the TP53 rs1042522 C>G polymorphism and hepatoblastoma risk in Chinese children

Abstract

The TP53 gene encodes an important class of cell cycle and tumor-suppressing factors that play critical roles in maintaining genomic stability. The TP53 Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk of several types of adult cancers; however, its risk for pediatric cancers remains unclear. Here, we analyzed the association of the TP53 gene rs1042522 C>G polymorphism with hepatoblastoma (HB) susceptibility in a hospital-based study among Chinese children. A total of 213 HB patients and 958 healthy controls were enrolled in the study. Genotypes were determined by a TaqMan assay, and the strength of the association was assessed by the odds ratios and 95% confidence intervals generated from logistic regression models, adjusted for age, gender, and clinical stage. No significant association between the TP53 rs1042522 C>G polymorphism and HB susceptibility was detected in the main analysis or in stratification analyses of age, gender, and clinical stages. Overall, the TP53 gene rs1042522 C>G polymorphism is not associated with HB susceptibility in the Chinese population, other polymorphisms alone or in combination should be investigated to further clarify HB susceptibility.

ALKBH5 Gene Polymorphisms and Hepatoblastoma Susceptibility in Chinese Children

“…Details of the selection of subjects and collection of specimens have been published elsewhere [ 22 , 23 ]. This is a collaborative study with hepatoblastoma cases and controls enrolled from eight hospitals in China.…”

“…To discover more variants predicting the risk of hepatoblastoma, here we conducted a multicenter case-control study among children of Chinese ancestry. [22,23]. is is a collaborative study with hepatoblastoma cases and controls enrolled from eight hospitals in China.…”

“…To solve this dilemma, our group has been working along with other centers to recruit as many hepatoblastoma cases as possible to shed light on the genetic etiology of hepatoblastoma. We have found that SNPs in LINC00673 , NRAS , KRAS , and TP53 genes may modify the risk of hepatoblastoma in the Chinese population [ 21 – 23 ]. The rarity of the disease has impaired the adequate investigation of their etiology.…”

<p><em>HMGA2</em> Polymorphisms and Hepatoblastoma Susceptibility: A Five-Center Case-Control Study</p>

“…A detailed description of subjects could be found in the previously published studies. 15,16 The study protocol was permitted by the Ethics Committee of each participating hospital (Ethical approve number: 2017120101). This study was conducted in accordance with the Declaration of Helsinki.…”

“…[9][10][11][12] A few epidemiological reports have indicated that single nucleotide polymorphisms (SNPs) might also be predisposing factors for hepatoblastoma. [13][14][15][16] However, it is difficult to obtain a significant association owing to the scarcity of included patients. Therefore, unveiling the underlying etiology of hepatoblastoma using a larger sample size, especially causative genetic factors, is of great significance.…”