Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population

Abstract

ABSTRACT. The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the rs35767 and rs972936 IGF-1 polymorphisms. By comparing the demographic characteristics between patients and controls, patients with osteoporosis were found to be more likely to have a habit of alcohol drinking (P = 0.023). Furthermore, the BMD levels of the L 1 -L 4 vertebrae, femoral necks, total hips, and trochanters in patients with osteoporosis were significantly lower than those in controls. By conditional regression analysis, we found that the IGF-1 rs2288377 and rs972936 gene polymorphisms (2015) were not associated with the risk of osteoporosis (P < 0.05). However, the CT+TT genotype of rs35767 and the AG+GG genotype of rs972936 were significantly associated with lower BMD levels in the femoral neck. Overall, our study suggests that IGF-1 rs2288377 and rs972936 gene polymorphisms do not influence the risk osteoporosis.

Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk

“…Among these, 4 case-control studies met the inclusion criteria and were included in the final analyses. [ 23 – 26 ] Figure 1 summarizes the process of identifying eligible studies. All of the studies were published in English.…”

“…A total of 2807 participants took part in the studies, with 1 recruiting men and women, [ 25 ] and 3 women only. [ 23 , 24 , 26 ] Four studies investigated rs35767, [ 23 – 26 ] 3 studies assessed rs2288377, [ 23 – 25 ] and 3 studies evaluated rs5742612. [ 23 – 25 ] The pooled minor allele frequency for rs35767, rs2288377, rs5742612 was 0.291 (95% CI: 0.275–0.308), 0.100 (95% CI: 0.088–0.113), and 0.131 (95% CI: 0.118–0.146), respectively.…”

Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: a meta-analysis

“…Of the six studies, five [ 17 , 25 – 27 , 29 ] referred to rs35767, rs2288377, and rs5742612. While Wei et al’s study [ 28 ] focused on rs35767 and rs972936. Three studies [ 25 , 27 , 29 ] reported both male and female participants, yet the remaining three studies [ 17 , 26 , 28 ] focused on the association in only post-menopausal women subjects.…”

“…While Wei et al’s study [ 28 ] focused on rs35767 and rs972936. Three studies [ 25 , 27 , 29 ] reported both male and female participants, yet the remaining three studies [ 17 , 26 , 28 ] focused on the association in only post-menopausal women subjects. The genotype frequencies of both case and control groups were summarized in Table 1 .…”

“…Firstly, we established a more comprehensive literature search strategy for potentially eligible literature, and the literature search and screen yielded six studies including 2068 cases and 2071 controls, while Chen et al [ 18 ] only obtained four studies with 1402 cases and 1405 controls. Except for four studies [ 17 , 26 , 28 , 29 ] included by Chen et al, we included two additional recently published studies [ 25 , 27 ] to increase the statistical power of our study. Secondly, Chen et al [ 18 ] performed their meta-analysis using multiple genetic models of inheritance without applying a correction for multiple testing.…”