Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Al-Serri, Ahmad; Ismael, Fatma G; Al-Bustan, Suzanne A.; Al-Rashdan, Ibrahim

doi:10.1177/1470320315610255

Cited by 11 publications

(10 citation statements)

References 38 publications

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“…This inference was also supported by several genetic based studies which showed that the carriers of ACE II genotype are at increased risk of developing insulin resistance [32,33] than ACE DD genotype carriers [32,34]. The ACE II genotype dependent risk of diabetes was also supported by the findings of current study and the report of Al-Serri et al also showed that ACE II genotype increase the risk of diabetes in CVD patients [12].…”

Section: Ace I/d Polymorphism Associated Disease Risksupporting

confidence: 85%

“…Likewise, D allele was also reported to be strongly associated with diabetes in Saudi Arabian and Indian Punjabi populations [25,26]. Conversely, Kuwaiti and North Indian population-based studies supported I allele or II genotype as risk factor for diabetes [12,27] which also favor findings of the current study. Overall, several studies have concluded that ACE I/D polymorphism is associated with diabetes; however, the risk genotype is variable in different populations and has to be elucidated for its association with disease for the target population or ethnic group.…”

Section: Association Of Clinical Anthropometric and Biochemical Parasupporting

confidence: 56%

“…This gene consists of 26 exons and encodes 2 transcript variants [9]. Insertion/Deletion (I/D) polymorphism (rs4340) consisting of 287 bp Alu repeats in intron 16 of ACE is extensively studied polymorphism, involved in controlling the plasma ACE activity [10] and found associated with various metabolic diseases [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Hussain

Abbas

Ahmed

et al. 2019

Exp Clin Endocrinol Diabetes

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Angiotensin converting enzyme (ACE), as part of renin angiotensin aldosterone system, is involved in blood pressure regulation and control several physiological functions. Insertion/Deletion (I/D) polymorphism of ACE has pronounced effects on development of metabolic diseases like diabetes, cardiovascular diseases (CVDs) and hypertension. However, association of I/D polymorphism with risk of diabetes in CVD patients is not known. The aim of present study was to check the association of ACE I/D polymorphism with risk of diabetes in subjects with CVD. For this, 531 subjects were sampled and divided into 3 groups; G1-H (healthy controls, n=117), G2-CN (cardiac patients without diabetes, n=271) and G3-CD (cardiac patients with diabetes, n=143). Genotyping of ACE I/D polymorphism was done by polymerase chain reaction. Allelic and genotypic frequencies were in Hardy Weinberg Equilibrium (χ2=0.11, p>0.05) and revealed high prevalence of I allele (55%) among all groups. However, II genotype was more common (37%) in G3-CD group. Level of glucose was also higher in subjects with II genotype than DD genotype (12.6±6.3 mmol/L vs. 9.7±5.1 mmol/L). Logistic regression analysis revealed that ACE II genotype increase the risk of diabetes in CVD patients by ~2 times [OR=1.94, CI: 1.24–3.01, p=0.03]; however, this association did not reach the significance level when adjusted for age and gender. In conclusion, ACE I/D polymorphism influence the risk of diabetes in CVD patients and ACE II increases this risk by ~2 fold.

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Section: Ace I/d Polymorphism Associated Disease Risksupporting

confidence: 85%

Section: Association Of Clinical Anthropometric and Biochemical Parasupporting

confidence: 56%

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Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Hussain

Abbas

Ahmed

et al. 2019

Exp Clin Endocrinol Diabetes

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“…Also, the DD genotype distribution was found to be significantly higher in diabetic patients in Tunis [ 6 , 35 ] and in Bahrain [ 36 ]. The ACE I allele was found to be associated with diabetes among Kuwaitis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study

et al. 2016

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BackgroundAccording to the WHO report in 2015, obesity is the fifth leading cause of death worldwide, and the prevalence of Egyptian female obesity is 37.5 %. Since obesity is highly influenced by genetics, and adipose tissue renin-angiotensin system is over-activated in obesity, the effect of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on obesity and related disorders was studied in several populations, because of its effect on ACE activity. Our objective was to study the association of ACE I/D polymorphism with obesity and certain related disorders, namely hypertension, insulin resistance and metabolic syndrome, in Egyptian females.MethodsEighty female volunteers were recruited, blood pressure and body measurements were recorded and a fasting blood sample was obtained for the quantitation of glucose, lipid profile, insulin, leptin and identification of ACE I/D polymorphs. Subjects were grouped based on hypertension and obesity states. Comparisons of continuous parameters were made with independent sample t-test between two groups. The frequencies of ACE genotypes and alleles, and the association between gene polymorphism and metabolic parameters were assessed using chi-square or Fisher's exact test.ResultsGenotype frequencies were in Hardy-Weinberg equilibrium for all groups. Genotype distribution did not differ significantly between controls and cases of all the studied disorders. Although DD carriers had apparently higher parameters of blood pressure, lipid profile and insulin resistance, only diastolic blood pressure was almost significant (p = 0.057). I-carriers were significantly less susceptible to hypertension than DD carriers having normal waist/hip ratio (p = 0.007, OR = 17.29, CI = 1.81–164.96) and normal conicity index (p = 0.024, OR = 7.00, CI = 1.36–35.93). In DD genotype carriers, a significant association was found between insulin resistance and high body mass index (p = 0.004, OR = 8.89, CI = 1.94–40.71), waist circumference (p = 0.003, OR = 9.63, CI = 2.14–43.36) and waist/height ratio (p = 0.034, OR = 6.86, CI = 1.25–37.61), although the variations in percentages between DD and I-carriers were not high enough to conclude an effect of ACE I/D on such an association.ConclusionsIn this sample of Egyptian females, ACE I/D polymorphism was not significantly associated with obesity nor with any of its related disorders studied. The I allele seemed protective against hypertension in subjects with normal, not high, waist/hip ratio and conicity index compared to DD genotype carriers.

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“…The association of advanced age, sex, nutrition, smoking, metabolic syndrome, and physical inactivity has been studied extensively and documented in the Kuwaiti population [ 2 , 6 , 7 ]. Limited studies have focused on the association of genetic factors with CHD in either the Kuwaiti population [ 8 – 10 ] or among Arab ethnic groups in general [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

et al. 2017

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Background Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results A statistically significant association (P < 0.001) between the rs11279109 DD genotype (OR: 2.43, CI: 1.34–4.41) with CHD was observed. A codominant genetic model revealed a 2.69 risk increase (CI: 1.57–4.61) for the DD genotype (P = 0.009) independent of age, sex, BMI, smoking, hypercholesterolemia, and ethnicity suggesting APOB rs11279109 as an indicator for the increased risk of CHD. Conclusion The DD genotype may explain molecular mechanisms that underline increased LDL oxidation leading to arthrosclerosis. The findings emphasize the need to identify genetic markers specific to the CHD patient ethnic group in order to improve prognosis and help in early diagnosis and prevention.

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Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Cited by 11 publications

References 38 publications

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

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