Association of the L3MBTL3 rs1125970 and rs4897367 Gene Polymorphisms With Coronary Heart Disease Susceptibility in the Chinese Population: A Case–Control Study

Abstract

Coronary heart disease (CHD) is a prevalent heart disease with the high incidence and mortality rates worldwide, and its pathogenesis is related to genetic factors. L3MBTL3 has been reported to be potentially linked to CHD susceptibility. This study aims to explore the correlation between L3MBTL3 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese population. Three SNPs (rs1125970 A/T, rs4897367 T/C, and rs2068957 A/G) in L3MBTL3 from 649 patients with CHD and 649 healthy controls were genotyped using the Agena MassARRAY platform. The relationship between SNPs and CHD risk was evaluated by logistic regression analysis. Our study indicated that rs1125970 (TT: OR = 0.76, p = 0.014) and rs4897367 (TT: OR = 0.74, p = 0.021) were related to a decreased susceptibility to CHD. Stratified analyses showed that rs1125970 could reduce the risk of CHD in males, subjects aged< 60 years, with a BMI< 24 kg/m2, and non-hypertensive patients. Rs4897367 exerted a risk-decreasing influence on CHD in non-diabetic patients. In the haplotype analysis, individuals with the Trs4897367Ars2068957 haplotype were less likely to develop CHD (OR = 0.74, p = 0.024). In summary, L3MBTL3 rs1125970 and rs4897367 were significantly correlated with a decreased susceptibility to CHD in the Chinese population.