Association of the LCT‐13910C&gt;T Polymorphism With Obesity and Its Modulation by Dairy Products in a Mediterranean Population

Corella, Dolores; Arregui, María; Coltell, Óscar; Portolés, Olga; Guillem-Sáiz, Patricia; Carrasco, Paula; Sorlí, José V.; Ortega-Azorín, Carolina; González, José I.; Ordovás, José M.

doi:10.1038/oby.2010.320

Cited by 65 publications

(66 citation statements)

References 41 publications

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“…In some populations, dairy consumption has been associated with a higher risk of obesity and metabolic syndrome [44,45,46]. In our study, we noted the LNP group had a slightly lower average BMI than the LP group.…”

Section: Discussionsupporting

confidence: 57%

Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study

Latorre

Besa²,

Parodi³

et al. 2014

Digestion

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Background and Study Aims: Lactase non-persistence (LNP), or primary hypolactasia, is a genetic condition that mediates lactose malabsorption and can cause lactose intolerance. Here we report the prevalence of lactose intolerance in a double-blind placebo study. Methods: The LCT C>T_-13910 variant was genotyped by RT-PCR in 121 volunteers and lactose malabsorption was assessed using the hydrogen breath test (HBT) after consuming 25 g of lactose. Lactose intolerance was assessed by scoring symptoms (SS) using a standardized questionnaire following challenge with a lactose solution or saccharose placebo. Results: The LNP genotype was observed in 57% of the volunteers, among whom 87% were HBT(+). In the HBT(+) group the median SS was 9 and in the HBT(-) group the median SS was 3 (p < 0.001). No difference was observed in the SS when both groups were challenged with the placebo. The most common symptoms included audible bowel sounds, abdominal pain and meteorism. In the ROC curve analysis, an SS ≥6 demonstrated 72% sensitivity and 81% specificity for predicting a positive HBT. To estimate prevalence, lactose intolerance was defined as the presence of an SS ≥6 points after subtracting the placebo effect and 34% of the study population met this definition. Conclusions: The LNP genotype was present in more than half of subjects evaluated and the observed prevalence of lactose intolerance was 34%.

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Section: Discussionsupporting

confidence: 57%

Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study

Latorre

Besa²,

Parodi³

et al. 2014

Digestion

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“…This aspect is of great importance and potentially provides a more direct link to understanding the role of the LCT gene and lactase production on BMI. While several other studies (Almon et al 2010;Corella et al 2011) have used dairy intake to elucidate the effects of the LCT gene on BMI, we consider counting servings of dairy to be potentially misrepresentative since dairy products can have a variety of calories, quantity, and lactose content, as previously mentioned. Other strengths of our study include an ethnically diverse sample, the inclusion of admixture estimates to control for population stratification, and very detailed body composition and anthropometric measurements.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have confirmed a positive association between the LP allele and BMI (Kettunen et al 2010;Corella et al 2011;Almon et al 2012); however, in children, association studies have shown increased dairy consumption in carriers of the LP allele but no marked association with BMI levels (Almon et al 2010). Additionally, others have described a negative association between dairy intake, regardless of fat content, and BMI (Slyper and Huang 2009), further implicating dairy products as both pro and anti-obesogenic (Remesar et al 1999;Berkey et al 2005;Skinner et al 2003;Lehtimäki et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Associations of the lactase persistence allele and lactose intake with body composition among multiethnic children

et al. 2013

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Childhood obesity is a worldwide health concern with a multifaceted and sometimes confounding etiology. Dairy products have been implicated as both proand anti-obesogenic, perhaps due to the confounding relationship between dairy, lactose consumption, and potential genetic predisposition. We aimed to understand how lactase persistence influenced obesity-related traits by observing the relationships among lactose consumption, a single nucleotide polymorphism (SNP) near the lactase (LCT) gene and body composition parameters in a sample of multiethnic children (n = 296, 7-12 years old). We hypothesized that individuals with the lactase persistence (LP) allele of the LCT SNP (rs4988235) would exhibit a greater degree of adiposity and that this relationship would be mediated by lactose consumption. Body composition variables were measured using dual X-ray absorptiometry and a registered dietitian assessed dietary intake of lactose. Statistical models were adjusted for sex, age, pubertal stage, ethnic group, genetic admixture, socio-economic status, and total energy intake. Our findings indicate a positive, significant association between the LP allele and body mass index (p = 0.034), fat mass index (FMI) (p = 0.043), and waist circumference (p = 0.008), with associations being stronger in males than in females. Our results also reveal that lactose consumption is positively and nearly significantly associated with FMI.

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“…Other loci, such as the Lactase gene (LCT) have been associated with BMI and abdominal obesity, but more studies are required to confirm associations (Kettunen et al 2010;Corella et al 2011;Almon et al 2012;Albuquerque et al 2013b). A study identified two new loci with body fat percentage: IRS1 and the other near SPRY2 (Kilpeläinen et al 2011b).…”

Section: Five Waves Of Gwasmentioning

confidence: 99%

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

et al. 2015

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Although the prevalence of obesity is increasing in most countries, partially due to ubiquitous exposure to energy dense foods, not everyone exposed to the current obesogenic environment shows unhealthy weight gain. This suggests that there are marked differences in genetic factors that increase vulnerability for excess weight gain. Indeed, evidence suggests that 40 to 70% of variance in unhealthy weight gain can be attributed to individual genetic variations. Moreover, emerging data imply that genetic vulnerability factors interact with environment risk, which is referred to as an epigenetic process.Whereas most scholars consider obesity to be a disorder that results from the interaction between lifestyle and genetic factors, its origin is complex, poorly understood, and extent treatments are typically ineffective. Like any other aspect of science, our knowledge about the genetic basis of obesity is under constant revision. The current paper provides a review on the origins, mechanisms, evolutionary explanation, prevention and treatment based on genotyping.

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Association of the LCT‐13910C>T Polymorphism With Obesity and Its Modulation by Dairy Products in a Mediterranean Population

Cited by 65 publications

References 41 publications

Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study

Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study

Associations of the lactase persistence allele and lactose intake with body composition among multiethnic children

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

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