Association of the lipoprotein lipase and Apolipoprotein C-II gene polymorphisms with risk of dyslipidemia in smokers and non-smokers male

Al-Samawi, Rithab Ibrahim; Smaism, Maha Fadil

doi:10.1016/j.ihj.2021.12.005

Cited by 5 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Russian people, LPL 106G/A (rs1801177) polymorphism was linked with an increased risk of CVD 97 . Hind III polymorphism in LPL gene was reported as an increased risk of dyslipidemia in Iraqi males 81,93 . Study reported that LPL ‐53G/C promoter region polymorphism has an independent risk factor for myocardial infarction in South Indian population 92 .…”

Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 99%

“…Lipoprotein lipase (LPL) plays a role to regulate the fat accumulation in adipocytes, as well as contributes in the thermogenesis in skeletal muscle 92 . LPL gene, present at chromosome 8p22, consists of 9 introns and 10 exons in wide range of ~35‐kb DNA 93 . Genetic variations in LPL gene are linked with impaired TG metabolism and worsen the course of the disease 94 .…”

Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 99%

“…92 LPL gene, present at chromosome 8p22, consists of 9 introns and 10 exons in wide range of ~35-kb DNA. 93 Genetic variations in LPL gene are linked with impaired TG metabolism and worsen the course of the disease. 94 Polymorphism in LPL gene was associated with higher plasma triglyceride and cholesterol levels leading to cause CVD and acute myocardial infarction in Caucasian populations.…”

Section: Lipid Metabolizing Enzymementioning

confidence: 99%

“…97 Hind III polymorphism in LPL gene was reported as an increased risk of dyslipidemia in Iraqi males. 81,93 Study reported that LPL -53G/C promoter region polymorphism has an independent risk factor for myocardial infarction in South Indian population. 92 Polymorphisms HindIII and S447X of LPL gene are associated with vulnerability of Type 2 diabetes (T2D) and hypertension diseases among Mexican families.…”

Section: Lipid Metabolizing Enzymementioning

confidence: 99%

See 3 more Smart Citations

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Shyamveer

Arif

Singh

2023

The Journal of Gene Medicine

View full text Add to dashboard Cite

Adipocytes play a crucial role in the metabolism of lipids and sugars. Their response varies depending on the circumstances or other factors influenced by physiological and metabolic stresses. People living with HIV (PLWH) experience different effects of HIV and highly active antiretroviral therapy (HAART) on their body fat. Some patients respond well to antiretroviral therapy (ART), while others taking similar regimens do not. The genetic makeup of patients has been strongly linked to the variable responses to HAART among PLWH. The cause of HIV-associated lipodystrophy syndrome (HALS) is not well understood, but it may be influenced by genetic variations in the host. The metabolism of lipid effectively modulates plasma triglyceride and high-density lipoprotein cholesterol levels in PLWH. Genes related to drug metabolism and transport play an important role in the transportation and metabolism of ART drugs. Genetic variation in metabolizing enzyme genes of antiretroviral drugs, lipid transport and transcription factor-related genes could interfere with fat storage and metabolism, contributing to the development of HALS. Hence we examined the impact of genes associated with transport, metabolism and various transcription factors in metabolic complications, and their impact on HALS. A study using databases such as PubMed, EMBASE and Google Scholar was conducted to understand the impact of these genes on metabolic complications and HALS. The present article discuss the changes in the expression and regulation of genes and their involvement in the lipid metabolism, lipolysis and lipogenesis pathways. Moreover, alteration of the drug transporter, metabolizing enzyme and various transcription factors can lead to HALS. Single-nucleotide polymorphisms in genes that play an essential role in drug metabolism and drug and lipid transportation may also contribute to individual differences in the emergence of metabolic and morphological alterations during HAART treatment.

show abstract

Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 99%

Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 99%

Section: Lipid Metabolizing Enzymementioning

confidence: 99%

Section: Lipid Metabolizing Enzymementioning

confidence: 99%

See 2 more Smart Citations

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Shyamveer

Arif

Singh

2023

The Journal of Gene Medicine

View full text Add to dashboard Cite

show abstract

“…LPL HindIII has also been investigated in an Iraqi smoking male population, which demonstrated associations between the lipid parameters of the smokers. Specifically, the genotypes of LPL HindIII polymorphism, H+H+ genotype group demonstrated significantly higher TG and VLDL-c concentrations while a significantly lower HDL-C concentration than those of the HeH- genotype [ 58 ]. Therefore, it seems that there were inconsistent findings in the LPL polymorphisms in terms of lipid parameters in the different populations.…”

Section: The Role Of Cholesterol-related Genes In Dyslipidemiamentioning

confidence: 99%

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

et al. 2022

View full text Add to dashboard Cite

Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS.

show abstract

Atherogenic Index of Plasma is a Novel Biomarker Associated with Obesity in the Adult Males

Al-Samawi,

A. Al-Kashwan,

A. Alsailawi

et al. 2023

View full text Add to dashboard Cite

The atherogenic index of plasma (AIP) is a vital parameter for dyslipidemia and its associated diseases and assessing cardiac risk. Several anthropometric parameters have been used to reflect obesity-associated risk, but body mass index (BMI) and waist/ hip (W/H) ratio are the most common. Our study aimed to evaluate the correlation between AIP and BMI, waist/ hip W/H ratio and its advantage in predicting dyslipidemia among obese males. The study includes 869 healthy Iraqi males, 415 obese and 454 non-obese males. The mean ± standard deviation (SD) body mass index was 33.00 ± 2.76 kg/m2 for the obese males and 22.49 ± 1.21kg/m2 for the non-obese males. AIP, BMI, W/H and lipid levels were estimated. The study demonstrated that AIP level was significantly correlated with both BMI, Pearson Correlation 0.295** and W/H ratio, Pearson Correlation 0.297**. The study revealed that AIP was significantly and positively associated with BMI and W/H ratio among the study population. Keywords: Obesity; Lipid; Atherogenic index of plasma; Males

show abstract

Association of the lipoprotein lipase and Apolipoprotein C-II gene polymorphisms with risk of dyslipidemia in smokers and non-smokers male

Cited by 5 publications

References 34 publications

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Atherogenic Index of Plasma is a Novel Biomarker Associated with Obesity in the Adult Males

Contact Info

Product

Resources

About