Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations

Chen, Zhou; Zhang, Shaofeng; Dong, Shouliang; Xu, Hao; Zhou, Wence

doi:10.3389/fimmu.2022.844401

Cited by 19 publications

(22 citation statements)

References 149 publications

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“…Despite substantial advances in understanding the importance of microbiota for human health, the potential impact of the microbiota on tumor growth, progression, and treatment response remained unclear until recently. Additionally, the fact that microbiota populations are large and symbiotic within the human body, influenced by factors like age, sex, immune competence, diet, climate, geography, and various other aspects, complicates the use of microbiota for precision therapy 143,531 . A thought‐provoking question is whether certain probiotics yield beneficial effects on the organism in specific environments, such as the gut, and whether their colonization in other tissues also offers benefits—this needs careful assessment.…”

Section: Discussionmentioning

confidence: 99%

“…Microbiota can alter the malignant phenotype of tumors by inducing inflammation, modulating the antitumor immune system, altering TME, and influencing cellular metabolism, and is strongly linked to tumor patients' prognosis 143,144 . TLR activated by microbiota can cause derangements of multiple tumor suppressor proteins (e.g., p16, p21, p27, p53, pRb, PTEN, and MAP2K4), induce STAT3 activation, and enhance EMT and oncogene‐induced senescence 145 .…”

Section: Microbiota and Tumorigenesismentioning

confidence: 99%

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Microbiota in cancer: molecular mechanisms and therapeutic interventions

Chen,

Guan,

Wang

et al. 2023

MedComm

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The diverse bacterial populations within the symbiotic microbiota play a pivotal role in both health and disease. Microbiota modulates critical aspects of tumor biology including cell proliferation, invasion, and metastasis. This regulation occurs through mechanisms like enhancing genomic damage, hindering gene repair, activating aberrant cell signaling pathways, influencing tumor cell metabolism, promoting revascularization, and remodeling the tumor immune microenvironment. These microbiota‐mediated effects significantly impact overall survival and the recurrence of tumors after surgery by affecting the efficacy of chemoradiotherapy. Moreover, leveraging the microbiota for the development of biovectors, probiotics, prebiotics, and synbiotics, in addition to utilizing antibiotics, dietary adjustments, defensins, oncolytic virotherapy, and fecal microbiota transplantation, offers promising alternatives for cancer treatment. Nonetheless, due to the extensive and diverse nature of the microbiota, along with tumor heterogeneity, the molecular mechanisms underlying the role of microbiota in cancer remain a subject of intense debate. In this context, we refocus on various cancers, delving into the molecular signaling pathways associated with the microbiota and its derivatives, the reshaping of the tumor microenvironmental matrix, and the impact on tolerance to tumor treatments such as chemotherapy and radiotherapy. This exploration aims to shed light on novel perspectives and potential applications in the field.

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Section: Discussionmentioning

confidence: 99%

Section: Microbiota and Tumorigenesismentioning

confidence: 99%

Microbiota in cancer: molecular mechanisms and therapeutic interventions

Chen,

Guan,

Wang

et al. 2023

MedComm

Self Cite

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“…Accumulating evidence suggests that microbiota play an important role in cancer by damaging cellular DNA, inducing transformation, activating and altering stromal cell components in the TME, and influencing cellular metabolism. 448,449 The microbiota characteristics under hypoxic conditions are currently not fully understood. Recent research has demonstrated that a combination of live bacteria and treatment modalities such as surgery, chemotherapy, and radiotherapy can produce good clinical outcomes.…”

Section: Biotherapymentioning

confidence: 99%

Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Zhou

Han

et al. 2023

Sig Transduct Target Ther

Self Cite

338

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Having a hypoxic microenvironment is a common and salient feature of most solid tumors. Hypoxia has a profound effect on the biological behavior and malignant phenotype of cancer cells, mediates the effects of cancer chemotherapy, radiotherapy, and immunotherapy through complex mechanisms, and is closely associated with poor prognosis in various cancer patients. Accumulating studies have demonstrated that through normalization of the tumor vasculature, nanoparticle carriers and biocarriers can effectively increase the oxygen concentration in the tumor microenvironment, improve drug delivery and the efficacy of radiotherapy. They also increase infiltration of innate and adaptive anti-tumor immune cells to enhance the efficacy of immunotherapy. Furthermore, drugs targeting key genes associated with hypoxia, including hypoxia tracers, hypoxia-activated prodrugs, and drugs targeting hypoxia-inducible factors and downstream targets, can be used for visualization and quantitative analysis of tumor hypoxia and antitumor activity. However, the relationship between hypoxia and cancer is an area of research that requires further exploration. Here, we investigated the potential factors in the development of hypoxia in cancer, changes in signaling pathways that occur in cancer cells to adapt to hypoxic environments, the mechanisms of hypoxia-induced cancer immune tolerance, chemotherapeutic tolerance, and enhanced radiation tolerance, as well as the insights and applications of hypoxia in cancer therapy.

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“…[ 138 ]. The aforementioned microbiota was reported to be strongly associated with the onset and progression of PC, which makes it possible as a biomarker for the noninvasive diagnosis of this disease [ 174 ].…”

Section: Pc and The Microbiomementioning

confidence: 99%

Microbiota Regulates Pancreatic Cancer Carcinogenesis through Altered Immune Response

et al. 2023

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The microbiota is present in many parts of the human body and plays essential roles. The most typical case is the occurrence and development of cancer. Pancreatic cancer (PC), one of the most aggressive and lethal types of cancer, has recently attracted the attention of researchers. Recent research has revealed that the microbiota regulates PC carcinogenesis via an altered immune response. Specifically, the microbiota, in several sites, including the oral cavity, gastrointestinal tract, and pancreatic tissue, along with the numerous small molecules and metabolites it produces, influences cancer progression and treatment by activating oncogenic signaling, enhancing oncogenic metabolic pathways, altering cancer cell proliferation, and triggering chronic inflammation that suppresses tumor immunity. Diagnostics and treatments based on or in combination with the microbiota offer novel insights to improve efficiency compared with existing therapies.

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Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations

Cited by 19 publications

References 149 publications

Microbiota in cancer: molecular mechanisms and therapeutic interventions

Microbiota in cancer: molecular mechanisms and therapeutic interventions

Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Microbiota Regulates Pancreatic Cancer Carcinogenesis through Altered Immune Response

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