Association of the new visceral adiposity index with coronary artery calcification and arterial stiffness in Korean population

Son, Da‐Hye; Ha, Hyun Su; Lee, Hye S.; Han, Donghee; Choi, Seung Young; Chun, Eun Ju; Han, Hyuk-Soo; Park, Sung H.; Sung, Jidong; Jung, Hae Ok; Lee, Ji Won; Chang, Hyuk Jae

doi:10.1016/j.numecd.2021.02.032

Cited by 9 publications

(15 citation statements)

References 29 publications

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“…A positive relationship was noted between it and atherosclerotic cardiovascular disease risk [24]. Recently, a Korean study also found that the NVAI had the highest predictive value for coronary atherosclerosis and arterial stiffness among five obesity indices [25]. This study introduced a new perspective by extending the research on the correlation between the NVAI and clinical diseases from the cardiovascular field to the renal disease field.…”

Section: Discussionmentioning

confidence: 82%

“…Therefore, alternative parameters have been developed, including the visceral adiposity index (VAI) [14], Chinese VAI (CVAI) [15], lipid accumulation product (LAP) [16], a body shape index (ABSI) [17], and metabolic score for visceral fat (METS-VF) [18], which have been shown to be related to CKD [19][20][21][22][23]. Recently, it was documented that a new VAI (NVAI) had a higher predictive value for cardiovascular diseases than other obesity indicators in the Korean population [24,25]. However, research exploring any association between the NVAI and SRD is still absent.…”

Section: Introductionmentioning

confidence: 99%

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The new visceral adiposity index outperforms traditional obesity indices as a predictor of subclinical renal damage in Chinese individuals: a cross-sectional study

Sun

Liao

et al. 2023

BMC Endocr Disord

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Background The new visceral adiposity index (NVAI) was superior to previous obesity indices in predicting cardiovascular diseases among Asians. Nevertheless, the utility of the NVAI for predicting chronic kidney disease is still unclear. The objective of this research was to explore the relationship between the NVAI and subclinical renal damage (SRD) and to investigate whether the NVAI outperforms other common obesity indices in predicting SRD in the Chinese population. Methods Participants in this cross-sectional study were from the Hanzhong Adolescent Hypertension Cohort. The NVAI and seven other common obesity indices were calculated, including body mass index, waist circumference, lipid accumulation product, visceral adiposity index, Chinese visceral adiposity index, a body shape index and metabolic score for visceral fat. Logistic regression models revealed the association between NVAI and SRD. The odds ratio (OR) and the 95% confidence interval (CI) were calculated to show the association between the two variables. The predictive power of eight obesity indices for SRD was evaluated through the receiver operating characteristic curve and area under the curve (AUC). In addition, the net reclassification index (NRI) and integrated discrimination improvement (IDI) were also applied to compare the incremental predictive value for SRD of different obesity indices. Results The median age of the 2358 subjects was 42.00 years. Across NVAI tertiles, the prevalence of SRD was 7.25%, 11.21%, and 21.60%, respectively. After adjusting for confounders, a high level of NVAI remained a risk factor for SRD. The ORs of the middle and top NVAI tertiles for SRD were 1.920 (95% CI: 1.322, 2.787) and 4.129 (95% CI: 2.750, 6.202), respectively. The AUC of the NVAI was 0.666 (95% CI: 0.647, 0.685), which was significantly larger than the AUC of any of the other obesity indicators. Moreover, the NRI and IDI were significantly improved when NVAI was added to the basic model for predicting SRD. Among eight obesity indices, NVAI had the highest NRI (0.392; 95% CI: 0.280, 0.503), and its IDI (0.021; 95% CI: 0.014, 0.027) was second only to that of the body mass index (0.023; 95% CI: 0.014, 0.032). Conclusions NVAI is independently and positively associated with SRD. Among the eight obesity indices, the NVAI shows the strongest predictive power for SRD in the Chinese population. The NVAI may be useful as an effective warning indicator of chronic kidney disease in Chinese adults.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The new visceral adiposity index outperforms traditional obesity indices as a predictor of subclinical renal damage in Chinese individuals: a cross-sectional study

Sun

Liao

et al. 2023

BMC Endocr Disord

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“…In the present study, VAI and LAP indices were significantly higher in CAS patients than in controls. Son et al [ 26 ] assessed the relationship between the dynamic change of VAI and the risk of carotid plaque in 23522 Chinese participants. They calculated VAI at baseline and follow-up and found a significant positive correlation between VAI and carotid plaque risk (HR, 1.53; 95% CI, 1.48-1.59 [P 0.001]) in a nonlinear dose-response pattern.…”

Section: Discussionmentioning

confidence: 99%

Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis

2023

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Nicotine dependence (ND) and visceral adiposity are emerging as independent risk factors for cardiovascular diseases, including carotid artery stenosis (CAS). This study aimed to determine the relationship between ND and the contribution of abdominal fat to the onset of CAS, which is indicated by a luminal narrowing of at least 60% as determined by duplex and/or Doppler ultrasound. We prospectively collected data from 60 patients with CAS and 60 age- and gender-matched healthy subjects. The Fagerström Test for Nicotine Dependence (FTND), a common research tool, was used in the study. The original questionnaire was designed to gather social and demographic data. Anthropometric measurements, visceral adiposity index (VAI), and lipid accumulation products (LAP) were used to assess obesity. Most patients showed a high or mild-moderate degree of ND: 46.67% and 35%, respectively. The median visceral adiposity index (VAI) and lipid accumulation product (LAP) in patients was 3.92 and 32.83, respectively. Prolonged smoking duration, increased intensity, and high ND are hallmarks of CAS patients.

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“…Previous studies have shown that VAT is associated with diabetes, hyperuricemia, metabolic syndrome, hypertension, atherosclerosis, and vascular calcification. [13][14][15][16][17][18] However, to our knowledge, the association between VAI and HF has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Association between visceral adiposity index and heart failure: A cross‐sectional study

Zhang

Sun

Liu

et al. 2023

Clinical Cardiology

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Background Obesity is an important risk factor for heart failure (HF). Hypothesis Visceral adiposity index (VAI) is a simple metric for assessing obesity; however, the association between VAI and risk for HF has not been studied. Methods A cross‐sectional study involving 28 764 participants ≥18 years of age from the National Health and Nutrition Examination Survey (NHANES), 2009–2018, in the United States was performed. VAI was calculated using body mass index (BMI), waist circumference (WC), triglycerides (TG), and high‐density lipoprotein cholesterol. VAI was analyzed as a continuous and categorical variable to examine its association with HF. Subgroup analysis was also performed. Results The highest VAI (fourth quartile [Q4]) was found among males, BMI, systolic and diastolic blood pressure, WC, hypertension, diabetes, liver disease, coronary heart disease, smoking, total cholesterol, and TG. More participants in Q4 took β‐receptor blockers, angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers/angiotensin receptor‐neprilysin inhibitor, calcium channel blockers, and antidiabetic and antihyperlipidemic medications. Participants with HF exhibited greater VAI. A per‐unit increase in VAI resulted in a 4% increased risk for HF (odds ratio [OR] 1.04 [95% confidence interval (CI) 1.02–1.05]). After multivariable adjustment, compared with the lowest quartile, the OR for Q3 was 1.55 (95% CI 1.24–1.94). Subgroup analysis revealed no significant interactions between VAI and specific subgroups. Conclusion VAI was independently associated with the risk for HF. As a noninvasive index of visceral adiposity, VAI could be used for a “one shot” assessment of HF risk and may serve as a novel marker.

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Association of the new visceral adiposity index with coronary artery calcification and arterial stiffness in Korean population

Cited by 9 publications

References 29 publications

The new visceral adiposity index outperforms traditional obesity indices as a predictor of subclinical renal damage in Chinese individuals: a cross-sectional study

The new visceral adiposity index outperforms traditional obesity indices as a predictor of subclinical renal damage in Chinese individuals: a cross-sectional study

Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis

Association between visceral adiposity index and heart failure: A cross‐sectional study

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