Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

Ohuchi, Masatsugu; Fujino, Kazunori; Kishimoto, Tomoko; Yamane, Tetsunobu; Hamamoto, Tetsu; Tabata, Toshihide; Tsujita, Yasuyuki; Matsushita, M; Takahashi, Keiichi; Matsumura, Kazuhiro; Eguchi, Yawara

doi:10.5551/jat.29439

Cited by 20 publications

(17 citation statements)

References 46 publications

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“…Recently, pMVs have been point out as biomarker of the vaso-occlusive phenotype-related severity in sickle cell anemia (Nebor et al, 2014). Furthermore, pMVs seem to be involved in the development of disseminated intravascular coagulopathy in critically ill patients but are not related to hospital mortality, while pMV/platelet ratio is independently associated to hospital mortality (Ohuchi et al, 2015). Finally, total pMVs were lower while activated platelet-derived MVs (P-Sel + ) were higher in preeclampsia than in healthy women, being involved in the hypercoagulable intravascular reaction during pregnancies complicated by preeclampsia (Campello et al, 2015).…”

Section: Platelet-derived Microvesicles and Cardiovascular Diseasementioning

confidence: 99%

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Suades²,

et al. 2016

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Reports in the last decade have suggested that the role of platelets in atherosclerosis and its thrombotic complications may be mediated, in part, by local secretion of platelet-derived microvesicles (pMVs), small cell blebs released during the platelet activation process. MVs are the most abundant cell-derived microvesicle subtype in the circulation. High concentrations of circulating MVs have been reported in patients with atherosclerosis, acute vascular syndromes, and/or diabetes mellitus, suggesting a potential correlation between the quantity of microvesicles and the clinical severity of the atherosclerotic disease. pMVs are considered to be biomarkers of disease but new information indicates that pMVs are also involved in signaling functions. pMVs evoke or promote haemostatic and inflammatory responses, neovascularization, cell survival, and apoptosis, processes involved in the pathophysiology of cardiovascular disease. This review is focused on the complex cross-talk between platelet-derived microvesicles, inflammatory cells and vascular elements and their relevance in the development of the atherosclerotic disease and its clinical outcomes, providing an updated state-of-the art of pMV involvement in atherothrombosis and pMV potential use as therapeutic agent influencing cardiovascular biomedicine in the future.

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Section: Platelet-derived Microvesicles and Cardiovascular Diseasementioning

confidence: 99%

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Suades²,

et al. 2016

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“…Furthermore, treatment of endothelial cells and monocytes with PDMPs prior to co-incubation modulates monocyte-endothelial cell interactions by increasing the expression of adhesion molecules on both cell types 52) . Recently, some associations between PDMP levels and clinical outcomes in critically ill patients have also been evaluated, in addition to the importance of PDMPs in inflammation 53) .…”

Section: Atherothrombosis and Mpsmentioning

confidence: 99%

Microparticle and Atherothrombotic Diseases

Nomura

2016

JAT

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Microparticles (MPs) are small membrane vesicles that are released from many different cell types by exocytotic budding of the plasma membrane in response to cellular activation or apoptosis. MPs may be involved in both physiological processes and clinical treatments because they express phospholipids, which function as procoagulants. Elevated levels of platelet-derived MPs, endothelial cell-derived MPs, and monocyte-derived MPs are observed in almost all thrombotic diseases occurring in venous and arterial beds. Several studies have shown that the quantity, cellular origin, and composition of circulating MPs depend on the type of disease, the disease state, and medical treatment. Although MPs were initially thought to be small particles with only procoagulant activity, they are now known to have many different functions. An increasing number of studies have identified new implications of elevated MPs in clinical disorders. On the basis of evidence available till date, the present review suggests that MPs may be a useful biomarker in identifying atherothrombosis.

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“…Recently, the importance of PDMPs in inflammation and DIC has been investigated 1,11) . The current study by Ohuchi et al 10) probes further into the role of PDMPs in DIC. They propose that PDMP quality influences the development of DIC in critically ill patients, and suggest that an elevated PDMP:platelet ratio may represent a state of platelet activation or an activated form of PDMPs.…”

Section: See Article Vol 22: 773-782mentioning

confidence: 99%

“…Additionally, the PDMP:platelet ratio was the only variable that was independently associated with hospital mortality. Ohuchi et al 10) conclude that PDMPs are involved in the development of DIC, but are not related to hospital mortality.…”

Section: See Article Vol 22: 773-782mentioning

confidence: 99%