Association of the Polymorphism of TRAIL with the Risk and Severity of Lumbar Disc Degeneration in Chinese Han Population

Abstract

The 1595C/T polymorphism of TRAIL may be adversely associated with the risk and severity of LDD in the Chinese Han population.

Genetic background of degenerative disc disease in the lumbar spine

“…Thus, the strength of their activities might be related to LDDs. 34,39,44,51,56,58,82,86,90,104,106) Matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of the intervertebral discs. A common 5A/6A polymorphism in the promoter region of the human MMP-3 has been identified 110) .…”

“…In this category, MMP-2, MMP-9, and MMP-12 were identified using Chinese and Norwegian populations 51,58,82,86,104,106) . Thrombospondin 2 44,54) THBSs 1 and 2 are intervertebral disc ECM proteins that regulate the effective levels of MMP-2 and MMP-9, which are key effectors of ECM remodeling.…”

“…Regarding the association of VDR and LDDs, 10 papers showed a positive association and 6 papers showed a negative association. Since then, two papers have been published 91,100) . One Italian paper found that LDH was associated with a low plasma concentration of receptor activator of nuclear factor kappa-B ligand (RANKL) and the presence of the F allele of VDR 100) .…”

“…Since then, two papers have been published 91,100) . One Italian paper found that LDH was associated with a low plasma concentration of receptor activator of nuclear factor kappa-B ligand (RANKL) and the presence of the F allele of VDR 100) . The other paper, from Brasil, described a positive association between FokI/T2C polymorphism of VDR and LDDs in 121 patients and 131 controls 91) .…”

“…Other genes (ADH2 49) , GCH1 68) , COMT 67,78) , HAPLN1 70) , Caspase 9 71,84) , GDF5 72) , FAS 73) , FASL 73) , BCL-2 77) , DR4 79) , PARK 2 80) , VEGF 87) , eNOS 87) , HIF-1α 88) , ADAMTS4 105) , ADAMTS5 92) , ADIPOQ 95) , and TRAIL 100,101) ) There are several genes whose genetic polymorphisms are associated with LDDs. The information is very important and interesting.…”