Association of the polymorphism of interleukin-1B (−511C/T) with type 2 diabetes mellitus patients with and without family history of a first degree relative with diabetes mellitus

Peer Review #1 of "Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis (v0.1)"

“…We identified 450 publications via the initial keyword search. After screening, 12 publications met our inclusion criteria (Achyut et al 2007;Blakemore et al 1996;Borilova Linhartova et al 2019;Cao et al 2013;Doody et al 2017;Lin et al 2016;Liu et al 2014;Muktabhant et al 2013;Tayel et al 2018;Zhang et al 2004a;Zhang et al 2004b;Zhou et al 2010), and 438 studies were excluded for containing duplicate data, missing critical data, and being review papers or studies that were not related to T2DM. Table 1 illustrates the characteristics of all included publications in this meta-analysis.…”

“…Table 1 illustrates the characteristics of all included publications in this meta-analysis. In terms of polymorphisms and diseases, 6 identified case-control studies, comprising 981 cases and 1225 controls, regarded IL-1RN (VNTR) to evaluate its association with T2DM risk (Achyut et al 2007;Blakemore et al 1996;Borilova Linhartova et al 2019;Zhang et al 2004a;Zhang et al 2004b;Zhou et al 2010), and 7 identified case-control studies, including 1679 cases and 1442 controls, tested the association between IL-IB (-511) and T2DM risk (Achyut et al 2007;Cao et al 2013;Doody et al 2017;Lin et al 2016;Liu et al 2014;Muktabhant et al 2013;Tayel et al 2018). Stratified by ethnicity, six publications were performed in East Asian (EA) populations (Cao et al 2013;Lin et al 2016;Liu et al 2014;Zhang et al 2004a;Zhang et al 2004b;Zhou et al 2010), two studies were undertaken in South Asian (SA) populations (Achyut et al 2007;Doody et al 2017), two studies were conducted in Caucasian populations (Blakemore et al 1996;Borilova Linhartova et al 2019), and the remaining studies were completed in Southeast Asian (SA) (Muktabhant et al 2013) and North African (NA 1 ) populations (Tayel et al 2018).…”

“…IL-1RN 1* (4 repeats) and IL-1RN 2* (2 repeats) are the most common, whereas the others occur much less frequently (< 5%) (Santtila et al 1998). Many genetic association studies have been performed to estimate the relationship of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk (Achyut et al 2007;Muktabhant et al 2013). Several results suggest that there is no relationship between them (Borilova Linhartova et al 2019;Muktabhant et al 2013), whereas B.R Achyut et al showed that both the IL-1B (-511) and IL-1RN (VNTR) polymorphisms were associated with susceptibility to T2DM as well as complications, and he indicated that T2 (IL-1β −511T/IL-1RN*2) haplotype was associated with a roughly twofold increased risk of T2DM (Achyut et al 2007).…”

“…Many genetic association studies have been performed to estimate the relationship of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk (Achyut et al 2007;Muktabhant et al 2013). Several results suggest that there is no relationship between them (Borilova Linhartova et al 2019;Muktabhant et al 2013), whereas B.R Achyut et al showed that both the IL-1B (-511) and IL-1RN (VNTR) polymorphisms were associated with susceptibility to T2DM as well as complications, and he indicated that T2 (IL-1β −511T/IL-1RN*2) haplotype was associated with a roughly twofold increased risk of T2DM (Achyut et al 2007). Considering the small sample sizes (n＜600) and varying population characteristics (ethnic differences) in different studies, the results are conflicting.…”

Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis

“…IL-1RN 1* (four repeats) and IL-1RN 2* (two repeats) are the most common, whereas the others occur much less frequently (<5%) ( Santtila, Savinainen & Hurme, 1998 ). Many genetic association studies have been performed to estimate the relationship of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk ( Achyut et al, 2007 ; Muktabhant et al, 2013 ). Several results suggest that there is no relationship between them ( Borilova Linhartova et al, 2019 ; Muktabhant et al, 2013 ), whereas Achyut et al, (2007) showed that both the IL-1B (-511) and IL-1RN (VNTR) polymorphisms were associated with susceptibility to T2DM as well as complications, and he indicated that T2 ( IL-1 β − 511T/IL-1RN*2 ) haplotype was associated with a roughly twofold increased risk of T2DM.…”