Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review

Silva, Andreia Soares da; Carvalho, Tatiana Lins; Ó, Kleyton Palmeira do; Nóbrega, Débora Nascimento da; Souza, Roberta dos Santos; Lima, Victor Fernando da Silva; Farias, Isabela Cristina Cordeiro; Belmont, Taciana Furtado de Mendonça; Cavalcanti, María Auxiliadora de Queiroz; Miranda-Filho, Demócrito de Barros

doi:10.1007/s11033-020-05441-3

Cited by 2 publications

(4 citation statements)

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“…PPAR‐γ is predominantly expressed in adipose tissue and is involved in lipid and energy metabolism. PPAR (Pro12Ala) rs1801282 polymorphism was correlated with low BMI and improved insulin sensitivity 155 …”

Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 97%

“…PPAR (Pro12Ala) rs1801282 polymorphism was correlated with low BMI and improved insulin sensitivity. 155 SREBP-1c is located on chromosome 17p11.2. 167 SREBP-1c involvement has been observed in various metabolic pathophysiological developments such as dyslipidemia, T2D, obesity, atherosclerosis, and lipodystrophy.…”

Section: Gene Involved In Regulation Of Lipid Development Of Art-asso...mentioning

confidence: 99%

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Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Shyamveer

Arif

Singh

2023

The Journal of Gene Medicine

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Adipocytes play a crucial role in the metabolism of lipids and sugars. Their response varies depending on the circumstances or other factors influenced by physiological and metabolic stresses. People living with HIV (PLWH) experience different effects of HIV and highly active antiretroviral therapy (HAART) on their body fat. Some patients respond well to antiretroviral therapy (ART), while others taking similar regimens do not. The genetic makeup of patients has been strongly linked to the variable responses to HAART among PLWH. The cause of HIV-associated lipodystrophy syndrome (HALS) is not well understood, but it may be influenced by genetic variations in the host. The metabolism of lipid effectively modulates plasma triglyceride and high-density lipoprotein cholesterol levels in PLWH. Genes related to drug metabolism and transport play an important role in the transportation and metabolism of ART drugs. Genetic variation in metabolizing enzyme genes of antiretroviral drugs, lipid transport and transcription factor-related genes could interfere with fat storage and metabolism, contributing to the development of HALS. Hence we examined the impact of genes associated with transport, metabolism and various transcription factors in metabolic complications, and their impact on HALS. A study using databases such as PubMed, EMBASE and Google Scholar was conducted to understand the impact of these genes on metabolic complications and HALS. The present article discuss the changes in the expression and regulation of genes and their involvement in the lipid metabolism, lipolysis and lipogenesis pathways. Moreover, alteration of the drug transporter, metabolizing enzyme and various transcription factors can lead to HALS. Single-nucleotide polymorphisms in genes that play an essential role in drug metabolism and drug and lipid transportation may also contribute to individual differences in the emergence of metabolic and morphological alterations during HAART treatment.

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Section: Genes Associated With Metabolism and Art‐associated Lipodyst...mentioning

confidence: 97%

Section: Gene Involved In Regulation Of Lipid Development Of Art-asso...mentioning

confidence: 99%

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Shyamveer

Arif

Singh

2023

The Journal of Gene Medicine

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“…Conversely, the T allele of the estrogen receptor-2 (ESR2) gene was linked with the development of lipoatrophy when contrasted with the reference C allele. Besides, the GG genotype and the G allele of matrix metalloproteinase-1 (MMP1) were correlated with lipodystrophy in HIV patients receiving HAART [ 110 ].…”

Section: Hivmentioning

confidence: 99%

“…ROS production is mediated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family complex as NOX1, NOX2, NOX4, and NOX5 [ 5 , 124 ]. NOX members are found in muscle tissue and represent the primary sources of ROS; its activity has been investigated in conditions such as hypertension, hypercholesterolemia, and endothelial dysfunction [ 110 , 111 , 112 , 125 , 126 , 127 ]. Another enzyme that generates ROS is xanthine oxidoreductase, principally found in the liver and gut, although distributed in smaller proportions in the lungs, kidneys, heart, and brain plasma.…”

Section: Hivmentioning

confidence: 99%

Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals

Jiménez-Osorio

Jaen-Vega

Fernández-Martínez

et al. 2022

IJMS

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Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects.

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Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review

Cited by 2 publications

References 62 publications

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals

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