Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Gao, Lin; Wang, L; Yun, Hu; Su, Li; Su, Xiulan

doi:10.4238/vol9-3gmr833

Cited by 22 publications

(20 citation statements)

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“…Family aggregation of hypertension in Mongolians suggests that genetic factors might play an important role in the etiology of hypertension in Mongolians. Our previous study confirmed that the chloride channel Kb gene, CLCNKB, and the PPARγ gene are involved in the genetic susceptibility to hypertension in Mongolians (Gao et al, 2010;Su et al, 2012). Furthermore, in a small study of 385 unrelated Mongolians (158 patients with hypertension vs 227 normotensive subjects), we previously examined the association of the SLC12A3 gene with hypertension in Mongolians using nine tagSNPs of the SLC12A3 gene (rs6499858, rs2289119, rs13306673, rs2010501, rs7188995, rs7204044, rs4784733, rs8063406, and rs2304478) (Chang et al, 2011b).…”

Section: Discussionsupporting

confidence: 51%

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

Liang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype distributions of all selected polymorphisms were consistent with Hardy-Weinberg equilibrium. The presence of the G allele in the rs7187932 polymorphism was found to be associated with an increased risk of hypertension (OR: 1.30; 95%CI = 1.00-1.38; P = 0.048), whereas the rs2399594 G allele was associated with a reduced risk for hypertension (OR: 0.76; 95%CI = 0.60-0.97; P = 0.030). No significant difference was observed for other alleles. Haplotype analysis revealed an association of the rs2399594 and rs711746 GG haplotype with a reduced risk for hypertension (OR: 0.76; 95%CI = 0.60-0.97; P = 0.029). No significant association was 10027 SLC12A3 SNPs and essential hypertension ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 10026-10036 (2015) observed between other haplotypes and hypertension. These results suggest that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.

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Section: Discussionsupporting

confidence: 51%

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

Liang

et al. 2015

Genet. Mol. Res.

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“…The novel finding of our study showing that adolescents carrying the variant allele Ala presented higher serum triacylglycerol and VLDL-C levels is consistent with literature reports for obese adults [26,27] and for adults with coronary artery disease [28]. High triacylglycerol levels are associated with cardiovascular events, as they are directly related to increasing concentrations of atherogenic particles of LDL-C and VLDL-C. High VLDL-C can aggravate dyslipidemia, because it competes with CM in the clearance regulated by lipoprotein lipase and its hepatic receptors [29].…”

Section: Discussionsupporting

confidence: 81%

Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors

Alves

Morais

Augusto

et al. 2017

Nutrire

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Background: Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene (PPARG − rs1801282 − Pro12Ala) and in apolipoprotein E gene (APOE − rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors. Methods: This was a cross-sectional study with 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student's t test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile. Results: Adolescents carrying PPARG Ala allele showed higher serum triglycerides (p = 0.0423) and very low-density lipoprotein (p = 0.0410) levels when compared to those carrying the wild genotype. For the APOE polymorphism, it was observed a trend of higher triglycerides (p = 0.0712) and very low-density lipoprotein (p = 0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPARG rs1801282 and APOE rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.

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“…The Pro12-to-Ala mutation in PPARγ has been studied in depth. This polymorphism is significantly associated with hypertension, although its association with insulin sensitivity is still controversial (Deeb et al, 1998;Altshuler et al, 2000;Ostgren et al, 2003;Rodriguez-Esparragon et al, 2003;Yliharsila et al, 2004;Lu et al, 2008;Gao et al, 2010). The investigated polymorphisms herein are all located in intronic regions, which could play a role in regulating the expression level of a gene.…”

Section: Discussionmentioning

confidence: 98%

“…The association of PPARγ polymorphisms with hypertension has been investigated in various populations (Douglas et al, 2001;Gouni-Berthold et al, 2005;Sookoian et al, 2005;Badii et al, 2008;Gallicchio et al, 2008;Dallongeville et al, 2009;Yoshida et al, 2009;Fan et al, 2010;Gao et al, 2010;Underwood et al, 2010;Shi et al, 2012). Given that the prevalence of hypertension is significantly different among races (Lackland et al, 2008), PPARγ was tested as a risk factor for hypertension in a Mongolian population.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study showed that the PPARγ2 Pro12Ala SNP is involved in genetic susceptibility to hypertension and metabolic lipid disorders in the Han population of Inner Mongolia (Gao et al, 2010). However, the association of PPARγ2 Pro12Ala with hypertension is controversial in other populations (Douglas et al, 2001;Ostgren et al, 2003;Rodriguez-Esparragon et al, 2003;Yliharsila et al, 2004;Gouni-Berthold et al, 2005;Sookoian et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Association of SNPs in the PPARγ gene and hypertension in a Mongolian population

Yang¹,

Rg²,

Py³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The association of single nucleotide polymorphisms (SNPs) in PPARγ with hypertension is controversial. The aim of the present study was to clarify the contributions of PPARγ genetic variants to hypertension through an association study. A total of 414 unrelated Mongolian herdsmen and 524 Han farmers were included in this study. Fourteen intronic SNPs were analyzed and genotyped using a polymerase chain reaction/ligase detection reaction assay. Prior to correction for multiple testing, the SNPs rs6802898 and rs12633551 were significantly associated with the prevalence of hypertension in the Han and Mongolian populations, respectively. The genetic association of each SNP with hypertension was individually tested using logistic regression. The SNP rs6802898 was associated with hypertension in both dominant (P = 0.033) and additive models (P = 0.026) in the Han population, whereas the SNP rs12633551 was associated with hypertension in both dominant (P = 0.014) and additive models (P = 0.0073) in the Mongolian population. Moreover, SNP rs12633551 had a significant effect on systolic and diastolic blood pressure response. However, none of these associations were statistically significant after Bonferroni correction for multiple testing, although there was a significant difference among the haplotypes in the Han and Mongolian populations. Interestingly, there was an association of the PPARγ haplotypes with hypertension even after 19295-19308 (2015) Bonferroni correction. Thus, determination of the PPARγ haplotypes in different populations may prove informative for assessment of the genetic risk for hypertension.

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Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Cited by 22 publications

References 20 publications

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors

Association of SNPs in the PPARγ gene and hypertension in a Mongolian population

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