Association of the PPARγ2 Pro12Ala and C1431T Polymorphisms with Type 2 Diabetes and Diabetic Retinopathy in a Sample of Egyptian Patients

Abstract

Background Peroxisome Proliferator Activated Receptor Gamma (PPAR-γ) is a pleotropic transcription factor. Given the pivotal roles of PPARγ in regulating metabolism, several studies in various ethnic populations have explored the association between variants in this gene and susceptibility to diabetes and its complications with conflicting results. Objective To evaluate the association of Pro12Ala and C1431T polymorphisms of PPARγ2 gene with Type 2 Diabetes (T2D), the risk of developing Diabetic Retinopathy (DR) and the severity of retinopathy, in a sample of Egyptian patients.