Association of the Quantity, Duration, and Type of Alcohol Consumption on the Development of Gouty Tophi

Han, Lin; Li, Runze; Lü, Jie; Ren, Wei; Ning, Chunping; Pang, Jingyuan; Sun, Jian; Wang, Yao; Sun, Wenyan; Liu, Zhen; Wang, Can; Wang, Xuefeng; Wang, Jing; Chen, Ying; Merriman, Tony R.; Li, Changgui

doi:10.1002/acr.24968

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Alcohol consumption was recently linked to tophi 33 and to a poor sUA outcome 22 in gout, and had also observed by us after 1 -year, 24 but alcohol consumption did not predict the 2-year sUA outcome. A familial interaction between obesity and alcohol consumption has been found to contribute to gout.…”

Section: Discussionsupporting

confidence: 60%

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

Uhlig,

Karoliussen,

Sexton

et al. 2023

RMD Open

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ObjectiveGout is associated with lifestyle, body mass index (BMI) and comorbidities, including dyslipidaemia. We studied how in actively treated patients, anthropometric measures and lipid levels changed over 2 years and whether they predicted gout outcomes.MethodsPatients with a recent gout flare and elevated serum urate (sUA) received gout education and treat-to-target urate-lowering therapy over 1 year. Anthropometric measures with BMI, waist circumference (WC) and waist–height ratio (WHR) as well as lipid levels were measured yearly over 2 years. We examined whether baseline anthropometric measures and lipid levels were related to flares and to achieving the sUA target.ResultsAt baseline, patients (n=211) were with mean age of 56.4 years and 95% were male. Over 2 years, anthropometric measures were largely unchanged while cholesterol and low-density lipoprotein cholesterol (LDL-C) were reduced at year 1. Anthropometric measures were associated with presence of tophi. Higher baseline WC (OR: 0.96 per cm, 95% CI: 0.93 to 0.99) decreased and high level of high-density lipoprotein cholesterol (OR: 5.1 per mmol/L, 95% CI: 1.2 to 22.1) increased the chance of sUA target achievement at year 2. High LDL-C (OR: 1.8 per mmol/L, 95% CI: 1.2 to 2.6) predicted the chance of having a gout flare during year 2.ConclusionIn actively treated patients with gout, anthropometric measures were largely unchanged over 2 years and lipid levels were reduced. High WC and lipid levels predicted unfavourable gout outcomes after 2 years.

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Section: Discussionsupporting

confidence: 60%

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

Uhlig,

Karoliussen,

Sexton

et al. 2023

RMD Open

View full text Add to dashboard Cite

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“…Recent analysis by Lin Han et al To determine that chronic and excessive alcohol consumption is a key predictor of tophi and subcutaneous tophi manifestations in patients with gout. In addition, their report linked weekly alcohol consumption to tophi progression in individuals who already had speculative tophi ( 54 ). These findings were corroborated by a study conducted by Tuhina Neogi et al, which demonstrated that the risk of gout recurrence was elevated irrespective of the type of alcoholic beverage consumed, and was linked to occasional alcohol intake ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between education attainment and gout, and the mediating role of modifiable risk factors: a Mendelian randomization study

Huang,

Chen,

Liu

et al. 2024

Front. Public Health

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ObjectiveTo investigate the causal relationship between educational attainment (EA) and gout, as well as the potential mediating effects of individual physical status (IPS) such as body mass index (BMI) and systolic blood pressure (SBP) and lifestyle habits (LH) including alcohol intake frequency (drinking), current tobacco smoking (smoking), and time spent watching television (TV).MethodsUtilizing two-sample Mendelian randomization (MR), we analyzed the causal effects of EA on gout risk, and of IPS (BMI and SBP) and LH (smoking, drinking, and TV time) on gout risk. Multivariable MR (MVMR) was employed to explore and quantify the mediating effects of IPS and LH on the causal relationship between EA and gout risk.ResultsAn elevation of educational attainment by one standard deviation (4.2 years) exhibited a protective effect against gout (odds ratio 0.724, 95% confidence interval 0.552–0.950; p = 0.020). We did not observe a causal relationship between smoking and gout, but BMI, SBP, drinking, and TV time were found to be causal risk factors for gout. Moreover, BMI, SBP, drinking, and TV time acted as mediating factors in the causal relationship between EA and gout risk, explaining 27.17, 14.83, 51.33, and 1.10% of the causal effects, respectively.ConclusionOur study indicates that having a genetically predicted higher level of EA may provide protection against gout. We found that this relationship is influenced by IPS factors such as BMI and SBP, as well as LH including drinking and TV time.

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Imaging comparative analysis of familial and sporadic gout in Chinese men by multijoint ultrasonography

Wen,

Ma,

Dang

et al. 2024

Front. Med.

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ObjectiveThis study aimed to compare the imaging features of bilateral knees, ankles, and the first metatarsophalangeal joint using high-frequency ultrasonography in male patients with familial and sporadic primary gout and sought to elucidate the relationship between the presence of tophi and various clinical indicators.MethodMale patients with primary gouty arthritis (GA) in the acute phase presenting to the Department of Rheumatology and Immunology at the First Affiliated Hospital of Chengdu Medical College from November 2020 to June 2022 were enrolled and classified into familial and sporadic gout groups. Comparative analyses of their clinical data and ultrasonographic imaging findings of the knees, ankles, and first metatarsophalangeal joints were performed between the groups. Univariate and multivariate logistic regression analyses, as well as receiver operating characteristic (ROC) analysis, were conducted to determine the effectiveness of significant factors in the prediction of tophi.ResultIn comparison to male patients with sporadic gout, those with familial primary gout exhibited lower age, body mass index, disease duration, and serum uric acid (SUA) levels. However, they demonstrated higher incidences of tophi and bone erosion (54.6% in familial gout vs. 35.1% in sporadic gout, p < 0.05; 71.2% in familial gout vs. 48.1% in sporadic gout, p < 0.05, respectively), with a greater prevalence of tophi in the right first metatarsophalangeal joint (44.2% in familial gout vs. 32.3% in sporadic gout, p < 0.05). Independent risk factors for tophi included family history (OR = 6.712), age (OR = 1.049), disease duration (OR = 1.134), and SUA levels (OR = 1.006). ROC analysis yielded an area under the curve of 0.883 (p < 0.05) for predicting joint tophi using these factors.ConclusionMale patients with familial primary GA in the acute phase experienced earlier onset, shorter disease duration compared to those with sporadic gout. They also had more affected joints, more frequent and a wider distribution of tophi, especially in the right first metatarsophalangeal joint. Family history, age, disease duration, and SUA levels are predictive of tophi formation.

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Association of the Quantity, Duration, and Type of Alcohol Consumption on the Development of Gouty Tophi

Cited by 3 publications

References 43 publications

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

The relationship between education attainment and gout, and the mediating role of modifiable risk factors: a Mendelian randomization study

Imaging comparative analysis of familial and sporadic gout in Chinese men by multijoint ultrasonography

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