Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period

Abstract

Conclusion This study indicates that IL-10 promoter polymorphism variants, smoking, and alcohol consumption increase the risk of recurrence and canceration in vocal leukoplakia. Objective This prospective, clinical trial was performed to evaluate the association of interleukin (IL)-10 promoter polymorphism variants and canceration and recurrence rates in vocal leukoplakia (a pre-cancerous laryngeal carcinoma lesion) over a 2-year period. Participants and method Sixty-one post-operative patients with vocal leukoplakia were enrolled in this prospective, observational study and genotyped for the IL-10 promoter gene (IL-10-1082 A/G, -819 T/C and -592 A/C) using pyrosequencing, and responded to a 2-year follow-up survey. Recurrence and canceration rates were used to evaluate the association between the genotype variants and the clinical outcome. Results There was an increased canceration rate in the variant genotype group compared to that in the normal genotype group in the 2-year follow-up period (18.4% vs 0%, p-value = 0.038). Compared with the non-smoker group, the smoker group had a higher recurrence rate of vocal leukoplakia (29.3% vs 5%, p-value =0.044). Likewise, the recurrence rate in the alcohol consumption group was also higher (30.6% vs 8%, p-value =0.034). The percentage of cancerization in the alcohol consumption group was significantly higher than that in the non-alcohol consumption group (19.4% vs 0%, p-value =0.035).

Biomarkers for Malignant Potential in Vocal Fold Leukoplakia: A State of the Art Review

“…Moreover, IL‐10 suppression of antigen presenting cell function in macrophages is dependent on expression of the hematopoietic cell–restricted E3 ubiquitin ligase March I, whereas in DCs, suppression is March I independent 40 . Zhou et al 41 found that there was a significantly higher cancerization rate in the IL‐10 promoter genetic variants group than in the normal genotype group after 2‐year follow‐up of post‐CO 2 laser resection surgery under microlaryngoscopy. However, IL‐10’s role in tumorigenesis and development is still controversial as there is evidence suggesting that IL‐10 has potent antitumor effects.…”

“…The second difference is noted in the analysis methods. For clinical prognostic studies, we consider binary classification model and its threshold (receiver operating curve analysis), 25 Pearson and Fisher exact χ 2 tests, 22,29,41,44,45,47,49 and Cox proportional hazards model (Kaplan‐Meier method) 28,30,37,38,46,48 more appropriate for yielding applicable data than 1‐way analysis of variance only 32 , 34 …”

“…The second difference is noted in the analysis methods. For clinical prognostic studies, we consider binary classification model and its threshold (receiver operating curve analysis), 25 Pearson and Fisher exact x 2 tests, 22,29,41,44,45,47,49 and Cox proportional hazards model (Kaplan-Meier method) 28,30,37,38,46,48 more appropriate for yielding applicable data than 1-way analysis of variance only. 32,34 Implications for Practice Since REMARK was published, 26,28 we could evaluate the quality of these 16 studies investigating biomarkers and their relationship with malignant potential of VFL.…”

Inferior Surface Leukoplakia of Vocal Folds: Risk of Recurrence: A Preliminary Study

“…Reported risk factors for recurrent VFL include alcohol consumption, smoking, gastroesophageal reflux, the site and size of the lesion, and the pathological grade of the initial lesion. [7][8][9][10] However, there are discrepancies in the literature regarding certain factors, specifically smoking and alcohol consumption, being associated with higher rates of recurrence. [7][8][9][10] Moreover, the recurrence risks associated with the pathological grade and site and size of the lesion remain controversial.…”

“…[7][8][9][10] However, there are discrepancies in the literature regarding certain factors, specifically smoking and alcohol consumption, being associated with higher rates of recurrence. [7][8][9][10] Moreover, the recurrence risks associated with the pathological grade and site and size of the lesion remain controversial. 4,7,[9][10][11] The risk of recurrence with lesions on the inferior surface of the vocal fold has not been examined.…”