Association of the relative change in weight and body mass index with lung function in teenagers and adults with cystic fibrosis: Influence of gender and diabetes

Megías, Marta Cano; Vasco, Pablo Guisado; Albarrán, Olga González; Ferreiro, Adelaida Lamas; Carro, Luís Máiz

doi:10.1016/j.endoen.2015.11.005

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…The high-risk group was half as efficient as the low-risk group for early-phase AUC INS/GLU , and only 60% as efficient for total and late-phase AUC INS/GLU . These findings demonstrate that individuals with CF who secrete less insulin in response to glucose and have lower beta cell function have a higher CFRD risk, a common theme found in other studies [30,31]. We also found that low-risk individuals had more favourable ISI, which worsened as CFRD risk increased.…”

Section: Discussionsupporting

confidence: 87%

Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis

et al. 2021

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Aims/hypothesis Cystic fibrosis-related diabetes (CFRD) affects up to 50% of adults with cystic fibrosis (CF) and its presence is associated with adverse effects on nutritional status and pulmonary function. Early diagnosis could minimise CFRD morbidity, yet current methods of an OGTT at 0 and 2 h yield unreliable results. Our aim was to determine which indices from a 2 h OGTT with sampling every 30 min might improve prediction of CFRD. Methods Cross-sectional analysis at baseline (n = 293) and observational prospective analysis (n = 185; mean follow-up of 7.5 ± 4.2 years) of the Montreal Cystic Fibrosis Cohort were performed. Blood glucose and insulinaemia OGTT variables were studied in relation to lung function (forced expiratory volume in 1 s [FEV1]), BMI and risk of developing CFRD. Results At baseline, maximum OGTT glucose (G max ) was negatively associated with FEV1 (p = 0.003). Other OGTT values, including classical 2 h glucose, were not. A higher G max was associated with lower insulin secretory capacity, delayed insulin peak timing and greater pancreatic insufficiency (p < 0.01). G max was positively associated with the risk of developing CFRD (p = 0.0029); no individual with a G max < 8 mmol/l developed CFRD over the following decade. No OGTT variable correlated to the rate of change in BMI or FEV1. Conclusions/interpretation In adults with CF, G max is strongly associated with the risk of developing CFRD; G max < 8 mmol/l could identify those at very low risk of future CFRD. G max is higher in individuals with pancreatic insufficiency and is associated with poorer insulin secretory capacity and pulmonary function. KeywordsAdult . Blood glucose variables . Cystic fibrosis . Lung function . Oral glucose tolerance test Abbreviations AUC INS/GLU I AUC /G AUC CF Cystic fibrosis CFRD Cystic fibrosis-related diabetes CFTR CF transmembrane conductance regulator FEV1 Forced expiratory volume in 1 s G AUC Total AUC for glucose G max Peak OGTT glucose I AUC Total AUC for insulin IGT Impaired glucose tolerance I max Peak OGTT insulin ISI Insulin sensitivity index MCFC Montreal Cystic Fibrosis Cohort NGT Normal glucose tolerance * Rémi Rabasa-Lhoret

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Section: Discussionsupporting

confidence: 87%

Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis

et al. 2021

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“…Low body weight in CF is a common problem, and is associated with poor clinical outcomes in CF [22][23][24]. Addressing this issue is critical to both acute and chronic care.…”

Section: Discussionmentioning

confidence: 99%

A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis

Plant

Downey

Eustace

et al. 2017

Journal of Cystic Fibrosis

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“…CFRD may reduce the patient’s weight, increasing the risk of death in CF patients. Many authors confirm that weight loss and BMI occur several years before the diagnosis of CFRD [ 35 , 36 ]. In our adult population, BMI at the diagnosis of CFRD was 19.2 ± 3.4 kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

Cystic Fibrosis-Related Diabetes in Poland

Rachel

Biesiadecki

Galiniak

2022

IJERPH

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Cystic fibrosis (CF) is the most common autosomal recessive inherited monogenic disease in Caucasians. As medical technology progresses and the quality of patient care improves, the survival time of patients with CF has increased, which results in more frequent comorbidities such as cystic fibrosis-related diabetes (CFRD). CFRD is the result of abnormal glucose metabolism characterized primarily by insulin deficiency, exacerbated periodically by insulin resistance. The aim of our study was to analyze the epidemiology of patients with CFRD in Poland on the basis of data collected from six CF treatment centers. Analyses were performed on 1157 CF patients who were treated at one of the six CF care centers. CFRD was diagnosed according to standard criteria. All data including demographics, types of CFTR mutations, CFRD duration, and microorganisms in the sputum were obtained from the patients’ medical history. Our study indicates that the prevalence of CFRD in Poland is 12.9%. CFRD was most often diagnosed between the ages of 11 and 20 (60% of patients), while 23% of patients were diagnosed between 21 and 30 years of age. Furthermore, we observed that approximately 3–5% of patients under the age of 10 had CFRD. We found out that the type of mutation did not affect the frequency of CFRD development. Factors that increased the risk of developing CFRD include underweight and chronic Pseudomonas aeruginosa infection. Due to the extended lifespan of CF patients, the number of CFRD patients is currently increasing. We believe that the results of our study may complement information from other studies or may be useful in planning health policy in Poland.

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Association of the relative change in weight and body mass index with lung function in teenagers and adults with cystic fibrosis: Influence of gender and diabetes

Cited by 7 publications

References 22 publications

Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis

Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis

A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis

Cystic Fibrosis-Related Diabetes in Poland

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