Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the IFIH1 gene with susceptibility to autoimmune diseases: a meta-analysis

Abstract

ObjectiveInterferon induced with helicase C domain 1 (IFIH1) single-nucleotide polymorphisms (SNP) rs1990760, rs3747517, and rs10930046 have been shown to be closely related to the risk of autoimmune diseases. The aim of this study was firstly to examine the association of the rs1990760 with type 1 diabetes (T1D) in a Chinese population. Secondly, to assess the association of SNP rs1990760, rs3747517, and rs10930046 with autoimmune diseases susceptibility.MethodsA total of 1,273 T1D patients and 1,010 healthy control subjects in a Chinese population were enrolled in this case-control study. Subsequently, we performed a meta-analysis on the association of the SNP rs1990760, rs3747517, and rs10930046 in the IFIH1 gene with susceptibility to autoimmune diseases. The random and fixed genetic effects models were used to evaluate the association and the effect sizes, including odds ratios (OR) and 95% confidence intervals (CI). Stratification analyses based on ethnicity and the type of autoimmune diseases were performed.ResultsIFIH1 SNP rs1990760 was not associated with a significant risk of T1D in the Chinese population in the case-control study. A total of 35 studies including 70,966 patients and 124,509 controls were identified and included in the meta-analysis. The results displayed significant associations between IFIH1 rs1990760 A allele and rs3747517 C allele and autoimmune diseases risk (OR=1.09, 95% CI: 1.01~1.17; OR=1.24, 95% CI: 1.15~1.25, respectively). Stratified analysis indicated a significant association rs1990760 and rs3747517 with autoimmune diseases risk in the Caucasian population (OR=1.11, 95% CI: 1.02~1.20, OR=1.29, 95% CI: 1.18~1.41, respectively).ConclusionsThis study revealed no association between IFIH1 SNP rs1990760 and T1D in Chinese. Furthermore, the meta-analysis indicated that rs1990760 and rs3747517 polymorphisms, confer susceptibility to autoimmune diseases, especially in the Caucasian population.

A novel intergenic variant linked to IFIH1 rs1990760 polymorphism, rs2111485, shows an association with susceptibility to coronavirus disease 2019 and influences IFIH1 protein levels.

“…This change may provide a potential molecular link between rs1990760 and viral infections such as COVID-19. In this context, it has been pointed out that the IFIH1 gene encodes the interferon-inducible RNA helicase, which plays an important role in antiviral innate immune responses (Xiao et al, 2023).…”

“…The IFIH1 protein is encoded by IFIH1 , a gene located in the long arm of human chromosome 2 at position 2q24.2. Naturally occurring single nucleotide polymorphisms (SNPs) of the IFIH1 gene have been studied worldwide, and some have shown an association with susceptibility to a number of autoimmune diseases (type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, and others) as well as infectious diseases such as COVID-19 (Muñiz-Banciella et al, 2023;Xiao et al, 2023). Among the IFIH1 SNPs that have attracted attention in the topic of COVID-19 susceptibility is rs1990760.…”