Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

Luis, Daniel Antonio de; Aller, R.; Izaola, Olatz; Primo, David; Romero, Enrique

doi:10.20960/nh.573

Cited by 22 publications

(22 citation statements)

References 31 publications

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“…In another study in Iran, MAF for healthy individuals was 42%, and the frequency of AA genotype was 16% [23], which these findings were approximately in line with the results of the present study. In accordance with our findings, some studies found that FTO rs9939609 polymorphism is strongly associated with insulin sensitivity and plasma leptin level [24,25]. Another study conducted on the association between FTO gene rs9939609 polymorphism and obesity-related hormones reported that the carriers of the A-allele had higher leptin levels, but this relationship disappeared after adjustment for BMI [26,27].…”

Section: Discussionsupporting

confidence: 91%

Association of FTO rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults

et al. 2020

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FTO gene polymorphisms are associated with obesity and food intake. This study aimed to investigate the association of FTO rs9939609 polymorphism genotypes with serum glucose, lipid profile and serum hormones level. This cross-sectional study was carried out on 196 randomly selected overweight adults. Anthropometric measurements including weight, height, body mass index (BMI), fat mass, and fat-free mass were assessed. Serum TGs, total cholesterol, HDL cholesterol, LDL cholesterol, glucose and insulin levels were measured. The FTO gene was Genotyped for rs9939609 polymorphism. Dietary intake was assessed by avalid 168-item semiquantitative food frequency questionnaire (FFQ). The homozygotes for the FTO rs9939609 risk allele (A) had higher serum leptin (p = 0.005, F: 5.131) and lower HDL (p = 0.001, F: 7.687) level than TT genotype. The differences between TT and AT genotypes were not significant. The association remained significant for HDL level after adjustments for age and sex, calorie intake, physical activity, and BMI. The association between rs9939609 polymorphism genotypes and leptin was disappeared after adjustments for calorie intake and physical activity. In conclusion, rs9939609 risk allele was associated with higher serum leptin and lower HDL levels in overweight people. Further studies are warranted. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 91%

Association of FTO rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults

et al. 2020

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“…Both associations remained significant after adjusting for age, maternal pre-gestational body weight and insulin therapy. Our results are mainly consistent with those of De Luis et al, who also observed that the minor A allele of the FTO rs9939609 was significantly associated with lower serum adiponectin concentrations independently of potential confounders including adiposity [14]. Regarding the association of the FTO SNPs with systemic inflammation, a German study has shown that rs9939609 A-allele was associated with increased levels of C-reactive protein (CRP) [15].…”

Section: Discussionsupporting

confidence: 91%

“…It has been suggested that the obesity-associated FTO SNPs may affect obesity through greater food intake and increased hunger/lowered satiety and through modulating adiposity factors. The FTO SNP rs9939609 has been found to be significantly associated with levels of circulating ghrelin and leptin [12, 13], which are key mediators of ingestive behavior, and has been significantly associated with serum adiponectin, an antihyperglycemic, antiatherogenic, and anti-inflammatory adipokine [14]. Additionally, FTO SNP rs9939609 has been related to systemic inflammation [15], which is implicated in insulin resistance and diabetogenesis [16].…”

Section: Introductionmentioning

confidence: 99%

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Saucedo

Valencia

Gutiérrez

et al. 2017

Diabetol Metab Syndr

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BackgroundObesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls.Methods80 women with GDM and 80 women with normal pregnancy were considered for the present study. Genotyping of selected SNPs in all study subjects was done using the Taq-Man assay and the adipokines and ghrelin were measured by immunoassays. Chi square test, odds ratios (OR) and their respective 95% confidence intervals were used to measure the strength of association between FTO SNPs and GDM.ResultsThere was no association among FTO SNPs and GDM. Interestingly, in GDM group, women carrying the risk alleles of the three SNPs had increased TNF-alpha, and decreased adiponectin levels; these associations remained significant after adjusting for pre-gestational body weight and age. Moreover, the risk allele of rs1421085 was also associated with increased weight gain during pregnancy.ConclusionsThe FTP SNPs rs8050136, rs9939609, and rs1421085 are not a major genetic regulator in the etiology of GDM in the studied ethnic group. However, these SNPs were associated with adiponectin and TNF-alpha concentrations in GDM subjects.

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“…This premise remains unclear in the literature. Authors like De Luis et al have related high triglycerides levels to the FTO rs9939609 homozygous form ( T/T ) in Spanish obese men [59], while others like Grunnet et al report an association to the FTO rs9939609 heterozygous form ( A/T ) [60]. We faced the limitation that we did not have access to the serum lipid levels of all our patients at the diagnosis.…”

Section: Discussionmentioning

confidence: 97%

Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men

Salgado-Montilla

Rodríguez-Cabán

Sánchez-García

et al. 2017

Can Res

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Background Obesity is prevalent in PR and has been associated with prostate cancer (PCa) mortality and aggressiveness. Polymorphisms (SNPs) rs9930506 and rs9939609 in the FTO gene have been associated with both obesity and PCa. The aim of this work was to ascertain whether the presence of these SNPs is associated with PCa risk and severity in a cohort of Puerto Rican men. Methods and findings The study population consisted of 513 Puerto Rican men age ranging from 40–79 years old who underwent radical prostatectomy (RP) as the first treatment for PCa and 128 healthy Puerto Rican men age ranging from 40–79 years old. Genomic DNA (gDNA) was extracted and SNPs were determined by Real-Time PCR. PCa severity was defined based on RP stage and Gleason Score. The relationship of FTO SNPs with demographic, clinical characteristics, PCa status and PCa severity were assessed. Logistic regression models with a 95% confidence interval (CI) determined SNPs interaction with PCa risk and severity odds ratio (ORs). Results and discussion BMI, age and PSA were considered as confounders. Hardy-Weinberg equilibrium was present for both SNPs. The heterozygous forms (A/G; T/A) were the most prevalent genotypes and the frequency of alleles and genotypes for both SNPs agreed with those published in 1000 genomes. Results suggest an inverse association between the mutated rs9939609 and the risk of having PCa (OR: 0.53, 95% CI: 0.31–0.92) and a positive association with overweight (OR: 1.05, 95% CI: 0.68–1.62). Importantly, among the cases that were overweight, those with mutated rs9939609 had a greater chance of high severity PCa (OR: 1.39, 95% CI: 0.84–2.32) although these results were not statistical significant upon adjustment. Limitations of the study were the relatively small cohort and lack of access to the weight history of all our subjects. Conclusion Results offer a research line to be followed with an expanded number of subjects that may provide a better statistical significance, to unravel the high mortality rate in this population.

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Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

Cited by 22 publications

References 31 publications

Association of FTO rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults

Association of FTO rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults

Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men

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