Association of the ‘Secretor State’ with the Presence and Recurrence of Urinary Infections in Pregnant Women

Biondi, Carla; Cotorruelo, Carlos; Balagué, Claudia; Toresani, Inés; Racca, Liliana; Mónaco, René Di; Fernández, L.; Racca, A.

doi:10.1177/000456329903600314

Cited by 9 publications

(11 citation statements)

References 5 publications

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“…Sheinfeld et al serologically phenotyped 49 Caucasian women and found a 3.4-fold increased risk of recurrent UTI in Le(bϪ) individuals or presumed nonsecretors (410). Similar findings were reported by Biondi et al, who reported a 26-fold increased risk of UTI in pregnant women who were typed as nonsecretors (76%, versus 12% of controls) (411). The impact of the nonsecretor phenotype, however, is tempered by reproductive and hormonal status.…”

Section: Uropathogenic E Colimentioning

confidence: 54%

“…These studies speculated that group B nonsecretors could have a cumulative increased risk due to (i) an absence of anti-B that might react with B-like epitopes on E. coli LPS (81, 427) and/or (ii) an absence of ␣Gal epitopes on secreted mucins, which could theoretically serve as a weak, false receptor (409). Other studies, however, found no association between UTI and patient ABO type (410,411,418). Likewise, human anti-A and anti-B failed to agglutinate several E. coli serotypes commonly isolated from E. coli UTIs (428).…”

Section: Uropathogenic E Colimentioning

confidence: 99%

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Blood Groups in Infection and Host Susceptibility

2015

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SUMMARY Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.

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Section: Uropathogenic E Colimentioning

confidence: 54%

Section: Uropathogenic E Colimentioning

confidence: 99%

Blood Groups in Infection and Host Susceptibility

2015

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“…Previous in vitro studies have shown that HMOs protect against uropathogenic Escherichia coli invasion and cytotoxicity [40] or induce growth defects in GBS [41], both common uropathogens associated with UTI. A study showed that negative secretor status was associated with higher incidence of UTI in pregnant women [42], indicating that secretor active structures in the urothelial site might protect from UTI. This seems partially contradictory to our finding that positive secretor status was associated with increased bacterial load in the urine, correlating with an increase of Gardnerella and Ureaplasma signatures.…”

Section: Discussionmentioning

confidence: 99%

Human Milk Oligosaccharides modulate the risk for preterm birth in a microbiome dependent and independent manner

Pausan

Kolovetsiou-Kreiner

Richter

et al. 2019

Preprint

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BackgroundPreterm birth is one of the leading causes of neonatal mortality. The causes for spontaneous preterm birth (PTB) are multifactorial and remain often unknown. In this study, we tested the hypothesis that human milk oligosaccharides (HMOs) in blood and urine modulate the maternal urinary and vaginal microbiome and influence the risk for PTB. We analyzed the vaginal and urinary microbiome of a cross-sectional cohort of women with and without preterm labor and correlated our findings with measurements of metabolites and HMOs in urine and blood. ResultsWe identified several microbial signatures associated with short cervix, PTB and/or preterm contractions such as Lactobacillus jensenii, L. gasseri, Ureaplasma sp. and Gardnerella sp..Additionally, we observed associations between sialylated HMOs, in particular 3'-sialyllactose, with PTB, short cervix and increased inflammation and confirmed an influence of HMOs on the microbiome profile. ConclusionsIdentifying serum and urinary HMOs and several key microorganisms associated with PTB, our findings point at two distinct processes modulating the risk for PTB. One process seems to be driven by sterile inflammation, characterized by increased concentrations of sialylated HMOs in serum.Another process might be microbiome-mediated, potentially driven by secretor-active HMOs in urine. Our results support current efforts to improve diagnostics and therapeutic strategies.

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“…Therefore, the high GC content and the high number of CpG dinucleotides might contribute to the high frequency of sequence variations in the FUT2 gene. It is open to investigation, however, whether such a large number of sequence variations are under any selection pressure because of the association of the secretor status with different infections 29‐39 …”

Section: Discussionmentioning

confidence: 99%

“…To a certain extent, the extensive polymorphism of the FUT2 locus is similar to that of the ABO locus, 28 which also stimulates a lot of interest. The reviving interest in FUT2 polymorphisms is also due to the association of the secretor status with different infections such as urinary tract infection, 29‐31 Helicobacter pylori infection, 32‐34 Norwalk virus infection, 35‐37 and human immunodeficiency virus infection 38,39 . This study describes the comprehensive screening of the FUT2 coding region for polymorphisms in a group of healthy Chinese and Caucasian subjects in Hong Kong.…”

mentioning

confidence: 99%