Association of the sickle cell trait and the ABO blood group with clinical severity of malaria in southwest Nigeria

Amodu, Olukemi K.; Olaniyan, Subulade A.; Adeyemo, Adebowale; Olumese, P.E.; Omotade, Olayemi O.

doi:10.1016/j.actatropica.2012.03.013

Cited by 19 publications

(26 citation statements)

References 41 publications

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“…is a leading cause of death for children under five years and pregnant women 4 . In Sub Saharan Africa, malaria in pregnancy is predominantly asymptomatic and yet a major cause of severe maternal anaemia and low birth weight babies strongly associated with marked increase in infant mortality 5. Malaria is endemic in Nigeria and its existence is well recognized and surveys reporting the prevalence in various communities in Nigeria [6][7][8] . Available records show that at least 50 percent of the population of Nigeria suffers from at least one episode of malaria each year 9 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Simon-Oke

2019

J. Biomed. Transl. Res.

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Background: Malaria is a deadly disease causing serious public health issues among pregnant women and children worldwide especially in tropical and subtropical Africa. This study was carried out to determine the prevalence of malaria parasites among pregnant women and children under five years in Ekiti State, Nigeria.Methodology: A total of 380 blood samples were collected from the pregnant women and children under five years respectively. Malaria parasites were examined microscopically on thick and thin blood smear stained with Giemsa stain while personal data were collected through questionnaire and confirmed from file records. Red cell phenotyping was carried out manually with standard tube technique for blood group. Haemoglobin electrophoresis was carried out using the cellulose acetate alkaline haemoglobin electrophoresis technique, which allowed for the separation of haemoglobin A, F, S, and C into distinct bands.Results: The results showed that of 380 pregnant women sampled, 153 (40.2%) were positive for malaria parasites and 63 (63%) were positive of the 100 children sampled. The highest prevalence of malaria parasites 18 (51.4%) and 25 (71.4%) were observed in ages 36-39 and <1 years for pregnant women and children respectively. Multigravidae was 1.19 times (95% Cl: 0.77, 1.84) more vulnerable to malaria compare to primigravidae. Women in the first trimester were more infected with malaria parasites 40 (75.4%) than those in second trimester 46 (23.3%) and third trimester 67 (51.9%). Among children under five years of age, females 38 (66.7%) had the highest prevalence compared to males 25 (58.1%). However, there was no significant difference. Statistical analysis showed a significant difference in genotype types (P<0.05).Conclusion: This study revealed that malaria infection is still endemic in the study area, hence, there is urgent need to deploy management strategy to the study area.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Simon-Oke

2019

J. Biomed. Transl. Res.

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“…Nigerian populations were also included in subsequent studies such as genome-wide association studies (GWAS) or post-GWAS studies for various cardiometabolic disorders (Adeyemo et al, 2015;Chen et al, 2017;Kang et al, 2010;Nandakumar et al, 2017;Reder et al, 2012;Tayo, Luke, Zhu, Adeyemo, & Cooper, 2009;Tayo et al, 2013). Studies of host genetic risk factors for infectious disease have also been done in Nigerian populations, especially in relation to malaria (Amodu et al, 2005(Amodu et al, , 2012Olaniyan et al, 2014Olaniyan et al, , 2016, including some in the context of international consortia such as MalariaGen (Olaniyan et al, 2014;Clarke et al, 2017).…”

Section: Nigeriamentioning

confidence: 99%

Medical genetics and genomic medicine in Nigeria

Adeyemo

Amodu

Ekure

et al. 2018

Molec Gen & Gen Med

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“…The area is a holo-endemic region characterized by yearround malaria transmission, with seasonal peaks between June-July and November-December [9]. In the study site, malaria presents as a range of sequelae ranging from mild presentation (uncomplicated malaria) to severe lifethreatening complications, such as severe malarial anaemia and cerebral malaria [7,9]. The sampling period was January-March 2016, a lower transmission season characterized by lower malaria incidence.…”

Section: Study Sitementioning

confidence: 99%

“…The sampling period was January-March 2016, a lower transmission season characterized by lower malaria incidence. Almost all the children recruited into this study (90%) were from the Yoruba ethnic group, the major ethnic group in the study area [7,9].…”

Section: Study Sitementioning

confidence: 99%

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Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection

Ademolue

Amodu

Awandare

2017

Clinical and Experimental Immunology

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SummaryThe controlled induction of haemoxygenase‐1 (HO‐1), an enzyme that catabolizes haem, has been shown to reduce haem, preventing pathologies associated with haem toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a longitudinal approach, we investigated the effect of baseline concentrations of HO‐1 on the accumulation of haem during acute Plasmodium falciparum malaria in HbAS and HbAA genotypes. Plasma concentrations of haem, HO‐1 and cytokines were quantified in venous blood obtained from children (9 months–5 years of age) during malaria infection, and at convalescence (baseline levels). Parasitaemia was determined during malaria infection. In patients with the HbAA genotype, there was a significant elevation in the plasma concentration of haem (P = 0.002), and a consequent increased induction of HO‐1 (P < 0.001) during falciparum malaria compared with levels at convalescence. Contrary to HbAA, plasma concentration of haem did not change in the HbAS genotypical group (P = 0·110), and the induction of HO‐1 was reduced during malaria compared with levels at convalescence (P = 0·006). Higher plasma levels of haem were observed in HbAS compared with HbAA at convalescence (P = 0·010), but this difference did not affect the levels of HO‐1 within each genotype (P = 0·450). Relatively milder proinflammatory responses were observed in HbAS children during malaria infection compared to HbAA children. Our findings suggest that a mechanism of reduced susceptibility to severe malaria pathologies by the HbAS genotype may involve the control of haem, leading to controlled levels of HO‐1 and milder proinflammatory responses during acute malaria.

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Association of the sickle cell trait and the ABO blood group with clinical severity of malaria in southwest Nigeria

Cited by 19 publications

References 41 publications

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Prevalence of Malaria Parasites among Pregnant Women and Children under Five years in Ekiti State, Southwest Nigeria.

Medical genetics and genomic medicine in Nigeria

Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection

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