Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program

Abstract

Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesity-related traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p<0.001). Additionally, we revealed that participants with the GG genotype had a higher low-density lipoprotein cholesterol (LDL-C) level (p=0.046) during the entire study period. It could be concluded that harboring the GG genotype of rs1800629 may be considered to be a disadvantageous factor in the context of training-induced effects on lipid profile changes in young female participants.

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

“…Association between the TNFA rs1800629 SNP and blood lipid levels produced conflicting results so far, mainly due to a wide variability of ethnicity, baseline CV risk, and interventions [ 23 , 24 , 25 ]. Here, we showed that the minor A allele is associated with higher TC and triglycerides.…”

Influence of IL-10, IL-6 and TNF-α gene polymorphism on obesity

“…Chang et al also found that the TNF-a-308 G>A gene polymorphism was linked to obesity (32), but Włodarczyk et al (33) found that the AA and GA genotypes of TNF-a 308 G>A were linked to a greater risk of obesity in men, but only the AG genotype was linked to a higher risk of obesity in women. The AA and GA homozygotes were also shown to have an increased risk of developing obesity-related metabolic disorders (34). Hedayati, on the other hand, found no link between the TNF-a 308 G>A gene polymorphism and obesity in an Iranian population (16).…”