Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study

López‐Jaramillo, Patricio; Gómez-Arbeláez, Diego; Martinez‐Bello, Daniel; Abat, Marc Evans M; Alhabib, Khalid F; Avezum, Álvaro; Барбараш, О. Л.; Chifamba, Jephat; Diaz, Maria L; Güleç, Sadi; Ismail, Noorhassim; Iqbal, Romaina; Kelishadi, Roya; Khatib, Rasha; Lanas, Fernando; Levitt, Naomi; Li, Yang; Mohan, Viswanathan; Mony, Prem; Poirier, Paul; Rosengren, Annika; Soman, Biju; Wang, Chuangshi; Wang, Yang; Yeates, Karen; Yusuf, Rita; Yusufali, Afzalhussein; Zatońska, Katarzyna; Rangarajan, Sumathy; Yusuf, Salim

doi:10.1016/s2666-7568(22)00247-1

Cited by 106 publications

(59 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, log transformed triglyceride/HDL ratio and triglyceride glucose index (a product of triglyceride and glucose concentrations) were identified as markers for insulin resistance, and cardiovascular and diabetes risk 31,32 . In concordance with published data, 1‐h PG positively correlated with baseline insulin resistance marker—log transformed triglyceride/HDL ratio in this study 31 (Figure ).…”

Section: Resultssupporting

confidence: 89%

“…31 Triglyceride glucose index, a product of triglycerides and PG, better reflects diabetes outcomes than glucose and triglyceride values alone. 32 Baseline 1-h PG correlated with circulating triglyceride concentrations, and baseline 1-h PG correlated with triglyceride glucose index in both groups. Furthermore, baseline triglyceride glucose index correlates with HOMA-IR in the diabetes group.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study

Dorcely,

DeBermont,

Gujral

et al. 2024

Obesity Science & Practice

View full text Add to dashboard Cite

ObjectiveHbA1c is an insensitive marker for assessing real‐time dysglycemia in obesity. This study investigated whether 1‐h plasma glucose level (1‐h PG) ≥155 mg/dL (8.6 mmol/L) during an oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) measurement of glucose variability (GV) better reflected dysglycemia than HbA1c after weight loss from metabolic and bariatric surgery.MethodsThis was a prospective cohort study of 10 participants with type 2 diabetes compared with 11 participants with non‐diabetes undergoing sleeve gastrectomy (SG). At each research visit; before SG, and 6 weeks and 6 months post‐SG, body weight, fasting lipid levels, and PG and insulin concentrations during an OGTT were analyzed. Mean amplitude of glycemic excursions (MAGE), a CGM‐derived GV index, was analyzed.ResultsThe 1‐h PG correlated with insulin resistance markers, triglyceride/HDL ratio and triglyceride glucose index in both groups before surgery. At 6 months, SG caused 22% weight loss in both groups. Despite a reduction in HbA1c by 3.0 ± 1.3% in the diabetes group (p < 0.01), 1‐h PG, and MAGE remained elevated, and the oral disposition index, which represents pancreatic β‐cell function, remained reduced in the diabetes group when compared to the non‐diabetes group.ConclusionsElevation of GV markers and reduced disposition index following SG‐induced weight loss in the diabetes group underscores persistent β‐cell dysfunction and the potential residual risk of diabetes complications.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Discussionmentioning

confidence: 80%

Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study

Dorcely,

DeBermont,

Gujral

et al. 2024

Obesity Science & Practice

View full text Add to dashboard Cite

show abstract

“…Accumulating retrospective studies have indicated that high TyG index levels seemed to be associated with an increased risk of major adverse cardiovascular events (MACEs) [24][25][26][27]. Moreover, recent data showed that higher TyG index re ected a more severe IR and was associated with poor outcomes due to all-cause and cardiovascular disease in a non-linear manner[28-30], suggesting that insulin resistance plays a promoting role in the pathogenesis of cardiovascular and metabolic diseases [31]. Furthermore, Zhao, S., et al [32] reported that an elevated TyG index was signi cantly related to a higher risk of both marco-and microvascular damage.…”

Section: Discussionmentioning

confidence: 99%

Association between Triglyceride glucose index and severity of diabetic foot ulcers in type2 diabetes mellitus

Zhang

Chen

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type2 diabetes mellitus (T2DM). Methods: A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl)×fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score <3) and severe DFUs (Wagner grade score ≥3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results. Results: Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017-1.865) (P =0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079-2.103) (P =0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD. Conclusions: Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders.

show abstract

“…Accumulating retrospective studies have indicated that high TyG index levels seemed to be associated with an increased risk of major adverse cardiovascular events (MACEs) [24][25][26][27]. Moreover, recent data showed that higher TyG index reflected a more severe IR and was associated with poor outcomes due to all-cause and cardiovascular disease in a non-linear manner [28][29][30], suggesting that insulin resistance plays a promoting role in the pathogenesis of cardiovascular and metabolic diseases [31]. Furthermore, Zhao, S., et al [32] reported that an elevated TyG index was significantly related to a higher risk of both marco-and microvascular damage.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus

Chen,

Wang,

Jiang

et al. 2023

Journal of Foot and Ankle Research

View full text Add to dashboard Cite

Background Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score < 3) and severe DFUs (Wagner grade score ≥ 3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results. Results Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017–1.865) (P = 0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079–2.103) (P = 0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD. Conclusions Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders.

show abstract

Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study

Cited by 106 publications

References 33 publications

Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study

Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study

Association between Triglyceride glucose index and severity of diabetic foot ulcers in type2 diabetes mellitus

Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus

Contact Info

Product

Resources

About