Association of the α-adducin polymorphism with blood pressure and risk of myocardial infarction

Psaty, Bruce M.; Doggen, Catharina Jacoba Maria; Vos, Hans L.; Vandenbroucke, Jan P.; Rosendaal, Frits R.

doi:10.1038/sj.jhh.1000943

Cited by 23 publications

(11 citation statements)

References 10 publications

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“…According to the authors, this finding might be attributed to premature death of the Trp allele carriers, supporting previous findings demonstrating an association between coronary events and this allelic variant in hypertensive patients [22,23].…”

Section: Recent Advances In the Genetics Of Salt-sensitive Hypertensionsupporting

confidence: 78%

Genetics of salt-sensitive hypertension

Strazzullo¹,

Galletti²

2007

Current Science Inc

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Excess dietary salt intake represents a predominant cause of hypertension. However, individual blood pressure response to salt is heterogeneous, possibly due to different inherited susceptibility. The early identification of rare monogenic forms of hypertension associated with abnormalities of renal tubular sodium handling and response to diuretics highlighted the important role of renal alterations in salt-sensitive hypertension. Thereafter, interest has concentrated on the identification of more common allelic variants of candidate genes for hypertension in relation to the salt-sensitivity phenotype. By now, relatively large numbers of such variants have been described, and the pathogenic role of gene-gene interaction has received increasing attention. The alternative approach, consisting of the search for quantitative trait loci in the human genome linked to the transmission of salt-sensitive hypertension, has so far been less successful and cost-effective. This review summarizes consolidated knowledge and discusses the most recent novel findings on the impact of genetic variance on salt-sensitivity of blood pressure.

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Section: Recent Advances In the Genetics Of Salt-sensitive Hypertensionsupporting

confidence: 78%

Genetics of salt-sensitive hypertension

Strazzullo¹,

Galletti²

2007

Current Science Inc

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“…They found evidence that ␣-adducin gene polymorphism is associated with some cases of essential hypertension in man, with plasma renin activity being lower in the predisposed subjects. 209 The findings have been supported by some, 211,212 but not all, [213][214][215][216] other workers.…”

Section: Genetic Aspectssupporting

confidence: 72%

The renin-angiotensin system in the year 2000

Nicholls

Robertson

2000

J Hum Hypertens

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“…Polymorphisms in adducin gene may be in part responsible for hypertension, in particular salt-sensitive hypertension, in human subjects. In order to verify this hypothesis, many studies were performed (Cusi et al 1997;Kamitani et al 1998;Ishikawa et al 1998;Kato et al 1998;Glorioso et al 1999;Wang et al 1999;Barlassina et al 2000;Bianchi et al 2000;Liu et al 2000;Melander et al 2000;Psaty et al 2000;Beeks et al 2001;Ciechanowicz et al 2001;Grant et al 2002;Sugimoto et al 2002;Castejon et al 2003;Siarrone et al 2003;Beeks et al 2004b;Shin et al 2004;Tamaki et al 2005;Manunta et al 2008). However, so far the results are not consistent.…”

Section: Introductionmentioning

confidence: 99%

Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis

et al. 2010

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Linkage and association studies suggested the relationship between alpha-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and alpha-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96, 2.04), P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI):1.33 (1.06, 1.69), P = 0.02] but not in Caucasian people [OR (95%CI):1.98 (0.57, 6.92), P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.

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Association of the α-adducin polymorphism with blood pressure and risk of myocardial infarction

Cited by 23 publications

References 10 publications

Genetics of salt-sensitive hypertension

Genetics of salt-sensitive hypertension

The renin-angiotensin system in the year 2000

Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis

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