Association of thiol/disulfide ratio with syntax score in patients with NSTEMI

Kundi, Harun; Erel, Özcan; Balun, Ahmet; Çiçekçioğlu, Hülya; Çetın, Mustafa; Kızıltunç, Emrullah; Neşeli̇oğlu, Salim; Topçuoğlu, Canan; Örnek, Ender

doi:10.3109/14017431.2015.1013153

Cited by 60 publications

(50 citation statements)

References 26 publications

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“…32) In fact, similar to previous studies, we found that the native thiol level was decreased whereas the disulfide level and disulfide/total thiol ratio were increased in all study patients as a result of oxidative damage. 30,33,34) Based on these findings, we can speculate that thiol/disulfide homeostasis was also altered in cancer patients during anthracycline therapy.…”

Section: Discussionmentioning

confidence: 99%

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

et al. 2017

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SummaryThe aim of the present study was to evaluate whether the baseline thiol/disulfide state can predict the occurrence of anthracycline induced cardiac toxicity. A total of 186 cancer patients receiving anthracycline (doxorubicin)-based chemotherapy were enrolled. All patients underwent 2-dimensional (2D) speckle tracking echocardiography (STE) to determine their left ventricular ejection fraction (LVEF) and blood samples for measuring thiol forms were obtained before treatment and 4 weeks after completion of the chemotherapy. The mean dose of doxorubicin exposure was 255 ± 39.2 mg/m 2 . Baseline native thiol was found to be lower whereas baseline disulfide and the disulfide/total thiol ratio were found to be higher in patients who had a decrease in LVEF after anthracycline therapy. Also, the amount of decrease in LVEF was well correlated with the delta value of the thiol forms. Logistic regression analysis revealed that changes in BNP and global longitudinal strain (GLS), baseline level of native thiol, disulfide, and the disulfide/total thiol ratio were strong predictors for a decrease in LVEF.The thiol/disulfide pathway may be a factor for predicting chemotherapy-induced cardiac toxicity as one of the oxidative stress mechanisms. (Int Heart J 2017; 58: 69-72)

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Section: Discussionmentioning

confidence: 99%

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

et al. 2017

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“…An abnormality in this homeostasis results with a variety of disorders since thiol/ disulphide ratio play critical roles in antioxidant protection, detoxification, signal transduction, regulation of enzymatic activity, apoptosis and cellular signaling mechanisms. 7 Cigarette smoking involves some species which reacts with thiols and that inactivate enzymes whose function involves thiol groups. Thus damaging effect of smoking occurs via antioxidant depletion and thiol destruction .…”

Section: Introductionmentioning

confidence: 99%

Thiol/disulfide homeostasis in asphalt workers

Yılmaz

Bal

Neşeli̇oğlu³

et al. 2016

Archives of Environmental & Occupational Health

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The aim of this study was to investigate thiol/disulfide homeostasis in asphalt workers who are exposed to polycyclic aromatic hydrocarbons occupationally. The study was carried out in 34 nonsmoker asphalt workers. Additionally, 35 healthy nonsmoker volunteers were recruited as control group. Thiol and disulfide concentrations were determined using the novel automated measurement method. Levels of urinary 1-OH-pyrene were analyzed by liquid chromatography. Disulfide/thiol ratio was significantly higher in exposed group (p = .034). Also, a positive correlation was detected between disulfide/thiol ratio and 1-OH-pyrene values (r = .249, p = .036). Thiol/disulfide homeostasis was found to be disturbed in asphalt workers. The novel test used in this study may be useful for evaluating the oxidative status in polycyclic aromatic hydrocarbon (PAH) exposure.

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“…These bonds may be reduced back to thiols, and thus thiol/disulphide homeostasis is sustained [8]. Recently it has been reported that the thiol/disulphide ratio is a novel oxidative stress marker, the level of which may alter in acute coronary syndromes [9,10]. Although there is a confirmed association of oxidative stress with atherosclerotic coronary heart disease, to our knowledge, there is no study that address thiol levels and thiol/disulphide homeostasis in stable CAD.…”

Section: Introductionmentioning

confidence: 99%

The relation of serum thiol levels and thiol/disulphide homeostasis with the severity of coronary artery disease

et al. 2016

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A b s t r a c tBackground: The balance of oxidant and antioxidant status plays a key role in the coronary artery diseases (CAD). Thiol is one of the most important antioxidant barriers in humans, and thiol/disulphide homeostasis is a novel oxidative stress marker. Aim:We aimed to investigate the relation of serum thiol levels and thiol/disulphide homeostasis with the presence and severity of CAD. Methods:A total of 161 patients who underwent coronary angiography owing to stable angina pectoris were consecutively enrolled. They were divided into three groups. Group I -47 age-and gender-matched subjects with normal coronary angiography (control); group II -71 newly diagnosed CAD patients with noncritical stenosis; and group III -43 newly diagnosed CAD patients with critical stenosis. Serum native thiol, total thiol, and disulphide levels were measured, and disulphide/thiol ratios were calculated. Gensini scores were calculated in CAD patients.Results: While the highest thiol levels were found in group I, the lowest one was observed in group III (p < 0.001). Total and native thiol levels were significantly lower in group II than in group I (p < 0.001 for each), but they increased considerably in group II compared with group III (p = 0.031 and p = 0.028, respectively). Disulphide levels decreased in group II and III compared with group I (p < 0.001 for each). No statistically significant changes were observed in disulphide/thiol ratios (p > 0.05). Gensini scores were negatively correlated with total and native thiols, and positively with age and dyslipidaemia.Stepwise linear regression analyses showed that native thiol was an independent predictor in the final model for Gensini score. Receiver operating characteristic curve analysis demonstrated that thiol values of 310.7 or below could predict CAD with 89% sensitivity and 85% specificity (AUC = 0.918; 95% CI 0.870-0.965). Conclusions:While the disulphide/thiol ratio did not change significantly, decreased native thiol levels were associated with the presence and severity of CAD. This result indicates that the reduction of thiols may be an important factor in the development of CAD.

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Association of thiol/disulfide ratio with syntax score in patients with NSTEMI

Abstract: TDR can be determined by an easy, inexpensive, automated, or optionally manual spectrophotometric assay, and correlates inversely with SXscore in patients with NSTEMI.

Cited by 60 publications

References 26 publications

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

Thiol/disulfide homeostasis in asphalt workers

The relation of serum thiol levels and thiol/disulphide homeostasis with the severity of coronary artery disease

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