Association of Thoracic Skeletal Muscle Index with Clinical Outcome and Response to Nutritional Interventions in Patients at Risk of Malnutrition—Secondary Analysis of a Randomized Trial

Mueller, Leonie; Mentil, Nicole; Staub, Nathalie; Griot, Stephanie; Olpe, Tobias; Burn, Felice; Schindera, Sebastian T.; Müeller, Beat; Schuetz, Philipp; Stanga, Zeno; Baumgartner, Annic

doi:10.3390/nu15040817

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Subsequently, all patients were divided into four gender-speci c quartiles according to their SMI values. The rst quartiles (containing the lowest SMI values) were considered sarcopenic as widely accepted in the previous literature [19].…”

Section: Assessment Of Sarcopeniamentioning

confidence: 99%

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Erkan,

OZCAN,

BEKIRCAVUSOGLU

et al. 2024

Preprint

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Purpose Sarcopenia is the presence of low skeletal muscle quantity or quality. It is associated with increased morbidity and mortality. Aortic arch calcification (AAC) is a type of vascular calcification that can be easily detected using chest X-rays. AAC and sarcopenia share common risk factors such as aging, inflammation, diabetes mellitus, and chronic kidney disease. In this study, we investigated the relationship between AAC and sarcopenia to evaluate whether chest X-rays can be used to predict sarcopenia in daily clinical practice. Methods AAC was assessed via a simple chest X-ray. Sarcopenia was evaluated using chest computed tomography imaging, which allows for the calculation of skeletal mass area (SMA) and skeletal mass index (SMI). Correlation analysis and multivariable models were used to assess the relationship between AAC and sarcopenia. Results A total of 340 patients were included in this study (122 with AAC, and 218 without AAC). Sarcopenia was more frequent in patients with AAC than those without (38.5% vs 16.5%, p < 0.001). SMI was also negatively correlated with the severity of AAC (r: -0.246, p < 0.001). In the multivariable model, AAC was independently related to age, glomerular filtration rate, and sarcopenia [(OR = 1.077, 95% CI 1.034–1.120, p < 0.001), (OR = 0.985, 95% CI 0.975–0.996, p = 0.008), and (OR = 1.812, 95% CI 1.030–3.188, p = 0.03), respectively)]. Conclusion AAC detected by simple chest X-rays is independently related to sarcopenia. It might be used to predict patients with sarcopenia in this population.

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Section: Assessment Of Sarcopeniamentioning

confidence: 99%

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Erkan,

OZCAN,

BEKIRCAVUSOGLU

et al. 2024

Preprint

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The chest CT perspective on sarcopenia: Exploring reference values for muscle mass quantity/quality and its application in elderly adults

Tao,

Shi,

Shen

et al. 2024

Nutrition

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The cross-talk between autoimmune diseases and sarcopenia (Preprint)

Gao,

Zhang,

et al. 2024

Preprint

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UNSTRUCTURED With the coming of aging society, the prevalence of sarcopenia increases rapidly. Sarcopenia is a progressive, generalized reduction in muscle mass, muscle strength, and physiological function accompany aging and it is a risk factor for many metabolic diseases. Previous studies found that immune cells take part in the whole process of muscle regeneration. Autoimmune diseases are a series of related diseases characterized by dysregulation of immune system, which could lead to inflammation and multi-tissue damage. Meanwhile, autoimmune diseases have a negative effect on the physiologic behavior of the skeletal muscles, which could exacerbate and accelerate the occurrence of sarcopenia. Among all of the autoimmune diseases, type 1 diabetes mellitus, rheumatoid arthritis, and inflammatory bowel disease are the three common immune diseases, and the interaction between them and sarcopenia is more likely to lead to adverse clinical outcomes, poor effects of drug treatment and prognosis, low quality of life, and the patients would under huge financial pressure. Thus, a comprehensive analysis of the relationships between the three autoimmune diseases and sarcopenia will help us better understand the potential mechanism, explore more effective treatments, guide clinical care and reduce complications. Moreover, it also provides new thinking for future scientific research.

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Association of Thoracic Skeletal Muscle Index with Clinical Outcome and Response to Nutritional Interventions in Patients at Risk of Malnutrition—Secondary Analysis of a Randomized Trial

Cited by 4 publications

References 30 publications

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

Sarcopenia is Associated with Aortic Arch Calcification on Chest X-ray in Unselected Middle- and Older-Aged Patients

The chest CT perspective on sarcopenia: Exploring reference values for muscle mass quantity/quality and its application in elderly adults

The cross-talk between autoimmune diseases and sarcopenia (Preprint)

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