Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Liu, Ying; Xiong, Lingxin; Zhou, Yan; Zheng, B. Z.; Liu, Tongjun; Xie, Wei

doi:10.1155/2018/7295131

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…Liu et al performed a meta-analysis exploring the association of SNPs from miRNAs and IBD. They reported three polymorphisms (rs11614913, rs2910146, and rs3746444) in miRNA-196a2, miRNA-146a, and miRNA-499 in patients with IBD [ 121 ].…”

Section: Epigenetics and Ibdmentioning

confidence: 99%

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Battistini

Ballan

Herkenhoff

et al. 2020

IJMS

110

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Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT), including Crohn’s disease (CD) and ulcerative colitis (UC), which differ in the location and lesion extensions. Both diseases are associated with microbiota dysbiosis, with a reduced population of butyrate-producing species, abnormal inflammatory response, and micronutrient deficiency (e.g., vitamin D hypovitaminosis). Vitamin D (VitD) is involved in immune cell differentiation, gut microbiota modulation, gene transcription, and barrier integrity. Vitamin D receptor (VDR) regulates the biological actions of the active VitD (1α,25-dihydroxyvitamin D3), and is involved in the genetic, environmental, immune, and microbial aspects of IBD. VitD deficiency is correlated with disease activity and its administration targeting a concentration of 30 ng/mL may have the potential to reduce disease activity. Moreover, VDR regulates functions of T cells and Paneth cells and modulates release of antimicrobial peptides in gut microbiota-host interactions. Meanwhile, beneficial microbial metabolites, e.g., butyrate, upregulate the VDR signaling. In this review, we summarize the clinical progress and mechanism studies on VitD/VDR related to gut microbiota modulation in IBD. We also discuss epigenetics in IBD and the probiotic regulation of VDR. Furthermore, we discuss the existing challenges and future directions. There is a lack of well-designed clinical trials exploring the appropriate dose and the influence of gender, age, ethnicity, genetics, microbiome, and metabolic disorders in IBD subtypes. To move forward, we need well-designed therapeutic studies to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation.

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Section: Epigenetics and Ibdmentioning

confidence: 99%

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Battistini

Ballan

Herkenhoff

et al. 2020

IJMS

110

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“…[11,12] In addition, another study demonstrated that rs2910164 was significantly associated with the susceptibility to inflammatory bowel disease. [13]…”

Section: Introductionmentioning

confidence: 99%

Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility

Gong

Zhang

et al. 2019

Medicine

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The rs2910164 single nucleotide polymorphism (SNP) in miR-146a has been implicated in the etiology of psoriasis in different relevant studies with contradictory conclusions and limited sample size. Therefore, the aim of this study was to undertake a systematic review and meta-analysis to estimate the association between rs2910164 SNP and psoriasis. We searched the databases of PubMed, EMBASE, Web of Science, WanFang, and Chinese National Knowledge Infrastructure (CNKI) to identify relevant literatures published before July 15, 2018. Four case–control studies including 2212 cases and 2274 healthy controls from 4 different countries met the predetermined criteria. The effect size was pooled by odds ratios (ORs) and 95% confidence intervals (95%CIs). Recessive model (CC vs CG+GG) was confirmed to be the optimal model. The results indicated that rs2910164 SNP was significantly associated with psoriasis (OR = 0.74, 95%CI 0.60–0.91, P = .004), and individuals with CC-genotype were predisposed to have decreased risk of psoriasis.

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Section: Vitamin D/vdr Epigenetic Role In Ibdmentioning

confidence: 99%

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Battistini¹,

Ballan²,

Herkenhoff³

et al. 2020

Preprint

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Inflammatory bowel disease (IBD) is a chronic disease in the gastrointestinal tract (GIT). IBD include ulcerative colitis (UC), which generally affects only the large intestine mucosa and submucosa, and Crohn’s disease (CD), which may affect any part of the GIT by transmural inflammation. Both UC and CD are associated with an imbalance of the gut microbiota composition and injuries in the intestinal mucosa. The intestinal dysbiosis is related to a reduction in butyrate-producing species, impairing the anti-inflammatory response of the immune system, and is commonly associated with micronutrients deficiency, e.g. vitamin D hypovitaminosis. Vitamin D is involved in several critical functions, including immune cell differentiation, regulation of microbiota, gene transcription, and barrier integrity. Vitamin D supplementation in IBD patients showed promising results in reducing the disease activity and modulating gut microbiota. Vitamin D receptor (VDR) regulates the biological actions of the active vitamin D metabolite, 1α,25-dihydroxyvitamin D3. Evidence supports that the VDR signaling is involved in the genetic, environmental, immune, and microbial aspects of IBD. Low VDR expression and dysfunction of vitamin D/VDR signaling are reported in IBD patients. Vitamin D/VDR deficiency could be considered as a multifunctional susceptibility factor in IBD. Therefore, in this review, we will discuss the progress in clinical studies, mechanism studies on Vitamin D /VDR, and potential use of vitamin D supplementation as adjuvant therapy to restore gut microbiota balance, promote beneficial metabolites, and inhibit inflammation status in patients with IBD.

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Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 27 publications

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

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