Association of Three Simple Insulin Resistance Indexes with Prehypertension in Normoglycemic Subjects

Fan, Jie; Gao, Song; Wang, Li Jun; Qian, Zhong Li; Zhou, Ze Quan; Liu, Xing Zhen

doi:10.1089/met.2019.0029

Cited by 31 publications

(33 citation statements)

References 28 publications

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“…14 However, Jie Fan, MB et al showed that MET-IR was significantly associated with prehypertension in subjects with normoglycemia, while TyG index and TG/HDL-c were not statistically significant. 10 In the present study, the logistic regression analysis showed that TyG index and TG/HDL-c were closely related to prehypertension and hypertension, and we also found that the distinguishing ability of TyG index was better than TG/HDL-c in hypertension. In future, we will explore whether elevated TYG and TG/ HDL-c can predict the major adverse cardiovascular events in hypertension individuals.…”

Section: Discussionsupporting

confidence: 69%

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

Zhang

Guo

Yang

et al. 2021

J of Clinical Hypertension

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Insulin resistance (IR) plays an important role in the development of hypertension. Triglyceride and glucose index (TyG index), and triglyceride to high‐density lipoprotein cholesterol ratio (TG/HDL‐c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross‐sectional study to explore the association of TyG index and TG/HDL‐c with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China. A total of 32 124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, which were normotension, prehypertension, and hypertension. In multiple logistic regression analysis, there was associated with prehypertension and hypertension when comparing the highest TyG index to the lowest TyG index and corresponding ORs were 1.795 (1.638, 1.968) and 2.439 (2.205, 2.698), respectively. For TG/HDL‐c, the corresponding ORs were 1.514 (1.382, 1.658) and 1.934 (1.751, 2.137), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TyG index and TG/HDL‐c, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG index and TG/HDL‐c levels were associated with prehypertension and hypertension in normoglycemic individuals. Moreover, the TyG index was more significant than TG/HDL‐c in distinguishing hypertension. They have the potential to become cost‐effective monitors in the hierarchical management of prehypertension and hypertension.

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Section: Discussionsupporting

confidence: 69%

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

Zhang

Guo

Yang

et al. 2021

J of Clinical Hypertension

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“…[10] However, Jie Fan, MB et.al showed that MET-IR was signi cantly associated with prehypertension in subjects with normoglycemia, while TyG index and TG/HDL-c were not statistically signi cant. [6] In the present study, the logistic regression analysis showed that TyG index and TG/HDL-c were closely related to prehypertension and hypertension, we also found that the predictive ability of TyG index was better than TG/HDL-c in hypertension. In future, we will explore whether elevated TYG and TG/HDL-c can predict the Major Adverse Cardiovascular Events in hypertension individuals.…”

Section: Discussionsupporting

confidence: 70%

“…[3] Homeostasis model assessment for IR (HOMA-IR) index is an indirect method, which need to measure insulin, so it is di cult to repeat the same results. [4][5][6] Therefore, a new index of insulin resistance is needed. At present, many studies evidenced that some simple routine biochemical indexes, such as the ratio of triglyceride to high density lipoprotein cholesterol (TG/HDL-c), the product of fasting triglyceride and glucose index (TYG), which can be calculated as non-insulin insulin resistance indicators and are more accurate and practical.…”

Section: Introductionmentioning

confidence: 99%

“…[10] However, few of these studies have large samples to study the relationship between non-insulin insulin resistance indicators and hypertension, prehypertension in the same population. [6,[9][10][11][12][13][14][15][16] Therefore, We conducted a large cross-sectional study to explore the association of TG/HDL ratio, TyG index with prehypertension and hypertension in the same normoglycemic subjects from China, Tianjin .…”

Section: Introductionmentioning

confidence: 99%

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The association of triglyceride and glucose index, triglyceride to high density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: a large cross-sectional population study 

Zhang

zhang

guo

et al. 2021

Preprint

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Background Triglyceride and glucose index (TYG) and triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-c) not only were significant association with hypertension, but also were related to prehypertension. However, few of these studies have large subjects to study the relationship between TyG ,TG/HDL and hypertension, prehypertension in the same population. Therefore, We conducted a large cross-sectional study to explore the association of TG/HDL-c, TyG index with prehypertension and hypertension in the same normoglycemic subjects from China, Tianjin . Methods A total of 32,124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, Which were normotension, prehypertension and hypertension. All participants completed a questionnaire, followed by a physical examination and blood sample test. Spearman’s correlation analysis was used to determine the correlation between TyG index, TG/HDL-c and their related parameters, Multiple Logistic regression analyses were applied to explore the association of TyG indexes and TG/HDL quartiles with prehypertension and hypertension. Results The association between TyG index ,TG/HDL-c and age, heart rate(HR),Body Mass Index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP), total cholesterol(TC), triglycerides(TG), LDL-cholesterol(LDL-c), fasting glucose(GLU) were positive correlation, while HDL-cholesterol(HDL-c) was negative correlation in spearman correlation analysis(p < 0.001). In multiple logistic regression analysis, there was a significant difference in the risk of prehypertension and hypertension when comparing the highest TyG index to the lowest TyG index and corresponding ORs were 1.795(1.638,1.968) and 2.439(2.205,2.698), respectively. For TG/HDL-c, the corresponding ORs were 1.514(1.382,1.658) and 1.934(1.751,2.137), respectively. Furthermore, When comparing the fourth quartile to the first quartile of TyG and TG/HDL, respectively, and both corresponding ORs of hypertension were higher than prehypertension. Conclusions Elevated TyG index and TG/HDL-c levels were associated with an increased risk of incident Prehypertension and Hypertension in normoglycemic individuals. They have the potential to become cost-effective and complementary monitors in the hierarchical management of prehypertension and hypertension.

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“…The diagnostic accuracy of these indices in metabolic syndrome has been shown [13]. The relationship of insulin resistance indices with the metabolic syndrome components, especially hypertension and prehypertension state, was investigated [9,[14][15][16]. In a study by Zeng et al, TyG, TyG-BMI, TyG-WC, and TyG-WHtR presented positive correlations with systolic and diastolic blood pressure in individuals with proper body mass index [16].…”

Section: Introductionmentioning

confidence: 99%

Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

Mirr

Skrypnik

Bogdański

et al. 2021

J Endocrinol Invest

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Purpose Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio). Methods The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese. Results All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome. Conclusions Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population.

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Association of Three Simple Insulin Resistance Indexes with Prehypertension in Normoglycemic Subjects

Cited by 31 publications

References 28 publications

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

The association of triglyceride and glucose index, triglyceride to high density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: a large cross-sectional population study

Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

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Association of Three Simple Insulin Resistance Indexes with Prehypertension in Normoglycemic Subjects

Cited by 31 publications

References 28 publications

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

The association of triglyceride and glucose index, triglyceride to high density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: a large cross-sectional population study&nbsp;

Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome

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The association of triglyceride and glucose index, triglyceride to high density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: a large cross-sectional population study