Association of thyroid dysfunction with suicide attempts in first-episode and drug naïve patients with major depressive disorder

Shen, Yanmei; Wu, Fengchun; Zhou, Yongjie; Ma, Yuejiao; Huang, Xingbing; Ning, Yuping; Lang, Xiaoe; Luo, Xuerong; Zhang, Xiangyang

doi:10.1016/j.jad.2019.08.067

Cited by 64 publications

(32 citation statements)

References 39 publications

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“…In our study, the researchers also found that the number of episodes was a predictive factor of SA in this study. A similar result was also been found in a representative study that showed that recurrent MDD appeared to confer a higher risk for suicidal behavior ( 52 ). Meanwhile, Chaudhury et al also emphasized the importance of the higher number of episodes of depression in SAs ( 50 ).…”

Section: Discussionsupporting

confidence: 86%

Incidence Trends and Risk Prediction Nomogram for Suicidal Attempts in Patients With Major Depressive Disorder

et al. 2021

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Background: Major depressive disorder (MDD) is often associated with suicidal attempt (SA). Therefore, predicting the risk factors of SA would improve clinical interventions, research, and treatment for MDD patients. This study aimed to create a nomogram model which predicted correlates of SA in patients with MDD within the Chinese population.Method: A cross-sectional survey among 474 patients was analyzed. All subjects met the diagnostic criteria of MDD according to the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). Multi-factor logistic regression analysis was used to explore demographic information and clinical characteristics associated with SA. A nomogram was further used to predict the risk of SA. Bootstrap re-sampling was used to internally validate the final model. Integrated Discrimination Improvement (IDI) and Akaike Information Criteria (AIC) were used to evaluate the capability of discrimination and calibration, respectively. Decision Curve Analysis (DCA) and the Receiver Operating Characteristic (ROC) curve was also used to evaluate the accuracy of the prediction model.Result: Multivariable logistic regression analysis showed that being married (OR = 0.473, 95% CI: 0.240 and 0.930) and a higher level of education (OR = 0.603, 95% CI: 0.464 and 0.784) decreased the risk of the SA. The higher number of episodes of depression (OR = 1.854, 95% CI: 1.040 and 3.303) increased the risk of SA in the model. The C-index of the nomogram was 0.715, with the internal (bootstrap) validation sets was 0.703. The Hosmer–Lemeshow test yielded a P-value of 0.33, suggesting a good fit of the prediction nomogram in the validation set.Conclusion: Our findings indicate that the demographic information and clinical characteristics of SA can be used in a nomogram to predict the risk of SA in Chinese MDD patients.

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Section: Discussionsupporting

confidence: 86%

Incidence Trends and Risk Prediction Nomogram for Suicidal Attempts in Patients With Major Depressive Disorder

et al. 2021

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“…Pompili et al reported that there was a difference in FT3 levels between suicidal attempters and non-suicidal attempters of patients with psychiatric illnesses including MDD, bipolar disorder, and psychotic disorders 23 . Our previous study also showed that serum levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), and thyroid peroxidases antibody (TPOAb) were higher in MDD patients with suicide attempts compared to MDD patients without suicide attempts 19 . However, to our best knowledge, few studies have investigated the risk factors of suicide attempts in MDD patients with anxiety symptoms, while considering the effects of metabolic dysfunction or thyroid hormones.…”

Section: Introductionmentioning

confidence: 90%

“…FEDN MDD patients can provide us with a unique opportunity to investigate suicide attempts in MDD patients with anxiety symptoms, with minimum effects of confounding factors, including drug treatment, course of disease, and comorbid medical diseases. Furthermore, some evidence suggests that some metabolic dysfunctions 17,18 and thyroid hormones are associated with suicide [19][20][21] . For example, Ma et al showed that there was an association between low cholesterol level and suicidal attempts in 288 of inpatients with MDD 17 .…”

Section: Introductionmentioning

confidence: 99%

The association of clinical correlates, metabolic parameters, and thyroid hormones with suicide attempts in first-episode and drug-naïve patients with major depressive disorder comorbid with anxiety: a large-scale cross-sectional study

et al. 2021

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The associated factors of suicide attempts in patients with major depressive disorder (MDD) comorbid with anxiety remains unclear. To the best of our knowledge, this is the first study with a large sample size that examines the risk factors of suicide attempts in first-episode drug-naïve (FEND) MDD patients comorbid with anxiety and includes clinical correlates, metabolic parameters, and thyroid hormone levels. A total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the symptoms of patients. Metabolic parameters and thyroid hormone levels were measured. The prevalence of suicide attempts in MDD patients comorbid anxiety symptoms was 24.28%, which was 9.51 times higher than that in MDD patients without anxiety symptoms (3.25%). Compared to non-attempters, MDD patients with anxiety symptoms who attempted suicide scored higher on HAMD and HAMA, and had higher systolic blood pressure, higher levels of thyroid stimulating hormone (TSH), and thyroid peroxidases antibody (TPOAb), which were also correlated with suicide attempts in MDD patients comorbid anxiety symptoms. The combination of HAMA score, HAMD score, and TSH could differentiate suicide attempters from non-suicide attempters. Further, the age of onset, illness duration, BMI, TSH, and TPOAb were associated with the times of suicide attempts in MDD patients comorbid anxiety symptoms. Our results demonstrate high prevalence of suicide attempts in MDD patients comorbid anxiety symptoms. Several clinical correlates, metabolic parameters, and thyroid hormones function contribute to the suicide attempts in MDD patients comorbid anxiety symptoms.

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“…Moreover, there has been little analysis on the careful measurement of variables concerned with psychopathology and few large sample capacity have been presented in previous studies ( 26 , 32 , 33 ). In a bid to redress these issues, our study recruited patients diagnosed as first-episode MDD patients who did not take anti-depressants to control the confounding variables and lessen the complications associated with chronic depression and its influence on suicide ( 34 ). Patients were selected according to age as this has a significant effect on comparing blood lipids: the level of blood lipids is shown to be positively correlated with age ( 35 ).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipid Levels and Suicide Attempts Within 2 Weeks in Patients With Major Depressive Disorder: Is There a Relationship?

et al. 2021

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The potential correlation between serum lipid profiles and suicidal tendencies has been previously reported, however, it is unclear whether serum lipid profiles have definite relevance to recently attempted suicides in individuals suffering from major depressive disorder (MDD). In this study, the relationship between blood lipids and suicide attempts in first-episode MDD patients in research were used to examine whether there is a connection. The cross-sectional study recruited 580 patients at the time of their first episode, measuring up to the diagnostic standard of MDD. Baseline demographic, clinical data, and blood lipid level data were collected. Depression severity was measured with the Hamilton Depression Rating Scale (HAMD). Our results revealed that the level of TC may be identified as a promising and effective biomarker for first-episode MDD suicide risk, suggesting that screening of serum lipid profiles in depressive patients is essential for suicide prevention.

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Association of thyroid dysfunction with suicide attempts in first-episode and drug naïve patients with major depressive disorder

Cited by 64 publications

References 39 publications

Incidence Trends and Risk Prediction Nomogram for Suicidal Attempts in Patients With Major Depressive Disorder

Incidence Trends and Risk Prediction Nomogram for Suicidal Attempts in Patients With Major Depressive Disorder

The association of clinical correlates, metabolic parameters, and thyroid hormones with suicide attempts in first-episode and drug-naïve patients with major depressive disorder comorbid with anxiety: a large-scale cross-sectional study

Serum Lipid Levels and Suicide Attempts Within 2 Weeks in Patients With Major Depressive Disorder: Is There a Relationship?

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