Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study

Abstract

Thyroid dysfunction (hyperthyroidism and hypothyroidism) may increase the risk of hypertension. 1 Hyperthyroidism and hypothyroidism are also common among hypertensive patients, 1 and hypertension guidelines suggest the need for evaluating the thyroid functions of hypertensive patients. 2 From the perspective of preventing hypertension induced by thyroid dysfunction, early intervention should be considered. Thus, it is essential to investigate the association between thyroid function and the indicators of

Thyroid Feedback Quantile-Based Index Is Associated With Blood Pressure and Other Hemodynamic Measures: A Cross-sectional Study

“…In current clinical practice, thyroid function was evaluated mainly based on the levels of TSH and thyroid hormone. Previous studies have shown that overt hyper-and hypothyroidism were wellestablished risk factors for hypertension 6,7,15 . A study performed 24-hour ambulatory blood pressure monitoring in subjects with thyroid dysfunction, and found that all the patients showed higher blood pressure than euthyroid subjects.…”

“…Some studies also detected a positive relationship between thyroid-stimulating hormone (TSH) and blood pressure in euthyroid population [9][10][11] , but others failed to obtain this result [12][13][14] . In addition, some study found a positive relationship between free thyroxine (FT4) and arterial stiffness 13,15 . However, the other came to the opposite conclusion 16 .…”

Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension

“…However, only few studies have explored the relationship between BP and thyroid hormones in healthy subjects, in order to understand whether different levels of thyroid hormones, within a physiological range, can reflect changes in BP. In this context, in the current issue of the Journal, Jamal and colleagues offer their elegant investigation conducted on 691 healthy subjects 3 . The authors elegantly show that in a physiological context, augmented serum levels of triiodothyronine (T3) and thyroxine (T4) are associated with an increase of both peripheral and central BP.…”

“…In this context, in the current issue of the Journal, Jamal and colleagues offer their elegant investigation conducted on 691 healthy subjects. 3 The authors elegantly show that in a physiological context, augmented serum levels of triiodothyronine (T3) and thyroxine (T4) are associated with an increase of both peripheral and central BP. A strength of the study is denoted by the choice to measure central BP, which is suggested to be a more reliable prognostic marker in cardiovascular disorder compared to conventional brachial cuff BP.…”

“…5,6 Another aspect that needs to be further examined is the potential role of the effects of T3 and T4 on the intricate interaction between cardiovascular and renal systems. [7][8][9] To better characterize the complex context in which the study performed by Jamal and colleagues 3 fits, here we propose a summary of the central mechanisms by which thyroid hormones can affect cardiac output, vascular resistances, and kidney function. We also summarize the results of the most recent clinical studies focused on the relationship between thyroid hormones and hypertension.…”