Association of time of obesity onset with comorbidities in treatment‐seeking men and women with severe obesity

Abstract

SummaryObjectivesEarly obesity onset is a risk factor for specific comorbidities in adulthood, but whether this relationship is present in men and women with severe obesity is unknown. This study aimed to examine whether obesity onset in childhood or adolescence, as compared with adulthood, is associated with higher odds of comorbidities in men and women with severe obesity.MethodsA cross‐sectional study of treatment‐seeking men and women with severe obesity attending a tertiary care centre in Norway, from 2006 to 2017, was performed.ResultsA total of 4,583 participants (69.13% women) were included. Almost all men (99.69%) and women (99.18%) suffered from ≥1 comorbidities. Compared with women, men were older (mean [SD]) (45.54 [12.14] vs. 42.56 [12.00] years, p < 0.001) and had higher body mass index (44.06 [6.16] vs. 43.39 [5.80] kg m−2, p < 0.001). The most prevalent comorbidities were non‐alcoholic fatty liver disease, dyslipidaemia and hypertension among men and dyslipidaemia, non‐alcoholic fatty liver disease and joint pain among women. After current age and body mass index were adjusted, childhood onset of obesity (0–11 years), compared with adult onset (>20 years), was associated with lower odds (OR [95% CI]) of obstructive sleep apnoea (OSA) in men (0.69 [0.53, 0.91], p < 0.01) and higher odds of OSA (1.49 [1.16, 1.91], p < 0.01) in women, and the interaction was significant (p < 0.01). Childhood onset of obesity was also associated with higher odds of coronary heart disease in men (1.82 [1.15, 2.89], p = 0.01) and type 2 diabetes in women (1.25 [1.01, 1.54], p = 0.04).ConclusionChildhood onset of obesity was associated with higher odds of coronary heart disease in men and OSA and type 2 diabetes in women, but with lower odds of OSA in men.

Anthropometry Measures and Prevalence of Obesity among Undergraduates of Public University Libya

“…Borgeraas et, al., (10) Bratke (11) investigate the connection between obesity and socioeconomic position (SEP) and find a strong relationship between obesity and SEP. High SEP is distinguished by education, wages, family resources, and house type. Obesity was discovered to grow with age.…”

The relationship between weight history and psychological health—Differences related to gender and weight loss patterns

“…In general, duration of being overweight as well as time of onset has been shown to predict risks of mortality and morbidity, possibly due to long-term exposure [ 14 ]. Even if an early onset is not a preliminary factor for being obese as an adult, studies suggest that becoming obese during childhood is a risk factor for staying obese until adolescence or even adulthood [ 15 ].…”

Multi-probiotic consumption sex-dependently interferes with MSG-induced obesity and concomitant phagocyte pro-inflammatory polarization in rats: Food for thought about personalized nutrition

“…Overweight and obesity are associated with numerous costly co-morbidities, including dyslipidemia, type 2 diabetes, chronic pain, cardiovascular diseases, hepatobiliary disorders, sleep apnea, osteoarthritis, respiratory problems, and certain cancers [ [14] , [15] , [16] ]. Male and female patients with obesity usually present with different comorbidities, what necessitates their stratification in different clusters at least [ 17 ]. The growing incidence of obesity in childhood and adolescence is of particular concern: more than 340 million overweight or obese children and adolescents are registered in 2016 [ 18 , 19 ].…”