Association of TNF-α and IL-10 polymorphisms with tuberculosis in Tunisian populations

Ben-Selma, Walid; Harizi, Hedi; Boukadida, Jalel

doi:10.1016/j.micinf.2011.04.009

Cited by 44 publications

(37 citation statements)

References 36 publications

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“…Ten studies were excluded because they did not contain extractable genotype data, were reviews, and other forms of tuberculosis; contained duplicate data or inconsistent genotype distributions in controls with respect to HWE; or were not published in the English language. Finally, 13 studies met the study inclusion criteria (Selvaraj et al, 2001;Scola et al, 2003;Correa et al, 2004;Amirzargar et al, 2006;Oh et al, 2007;Vejbaesya et al, 2007;Ates et al, 2008;Merza et al, 2009;Trajkov et al, 2009;Ma et al, 2010;Sharma et al, 2010;Ben-Selma et al, 2011;Varahram et al, 2014) (Figure 1), of which 12 studies examined TNF-α -308A/G, 6 examined -238A/G, and 4 examined -857T/C polymorphisms. The studies on the TNF-α -308A/G polymorphism involved 1751 patients with PTB and 1530 controls from four Asian, three European, three Middle Eastern, one African, and one South American population groups (Table 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Several studies have examined the potential contribution of TNF-α promoter polymorphisms to PTB susceptibility, but the findings of these studies are also inconsistent (Selvaraj et al, 2001;Scola et al, 2003;Correa et al, 2004;Amirzargar et al, 2006;Oh et al, 2007;Vejbaesya et al, 2007;Ates et al, 2008;Merza et al, 2009;Trajkov et al, 2009;Ma et al, 2010;Sharma et al, 2010;Ben-Selma et al, 2011;Varahram et al, 2014). Individual studies based on small sample sizes have insufficient statistical power to detect positive associations and are incapable of demonstrating the absence of an association.…”

Section: Introductionmentioning

confidence: 99%

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Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Lee¹,

Song²

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility. A total of 13 studies met the inclusion criteria, including 12, 6, and 4 studies on TNF-α -308A/G, -238A/G, and -857T/C polymorphisms, respectively. Metaanalysis showed no association between the TNF-α -308A allele and PTB susceptibility in all study subjects (odds ratio, OR = 1.182, 95%CI = 0.989-1.411, P = 0.066). After stratification by ethnicity, TNF-α -308A was not found to be associated with PTB in the European, Asian, or Middle East populations. No association was identified between PTB susceptibility and the TNF-α -238A allele in all study subjects (OR = 1.031, 95%CI = 0.741-1.436, P = 0.855), or in the European and Asian populations. However, TNF-α -857T was significantly associated with PTB susceptibility specifically in Asians (OR = 0.682, 95%CI = 0.550-0.846, P = 4.8 x 10 -5 ). Meta-analysis using the dominant model, recessive model, or homozygote contrast showed the same pattern of results as for the TNF-α -857T allele. Overall, no correlation was noted between the TNF-α -308A/G and -238A/G polymorphisms and PTB susceptibility. However, the TNF-α -857T/C polymorphism was found to be associated with PTB susceptibility in the Asian population.

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Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Lee¹,

Song²

2015

Genet. Mol. Res.

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“…Gene-gene interaction has been shown in some studies. A single gene that is not associated with susceptibility to TB will show an association if combined with other genes [38,39]. Besides, gene-agent interaction showed association of a certain host gene with a certain strain of Mycobacterium tuberculosis [40,41].…”

Section: Discussionmentioning

confidence: 99%

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

Siregar¹,

Sinaga²

2017

JHS

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Abstract:The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis (TB) pathogen M. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor (VDR), which ultimately produces the antimicrobial peptide Cathelicidin. Matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of VDR gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the FokI genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff 9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients (P > 0.05). Besides, there genotypic frequencies were in agreement with the Hardy-Weinberg Equilibrum (P > 0.05). However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB (OR 0.22, 95% CI: 0.11-0.45). ApaI and FokI polymorphisms of VDR gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

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“…Also, in a cytokine gene polymorphism analysis performed by Ben-Selma W et al, it was suggested that TNF-a _308 A allele was associated with increased susceptibility risk to EPTB and the _1082 AG genotype was significantly associated with increased risk development of EPTB in Tunisian populations. None of the IL-10 _819 and _592 C/A alleles or genotypes was associated with PTB and EPTB groups (11). In a Turkish study, Oral et al showed that IL-10-1082 G allele frequency was significantly associated with tuberculosis but did not show any significant difference with clinical forms of the disease (12).…”

Section: Discussionmentioning

confidence: 99%

“…The study of cytokine gene polymorphisms is a helpful tool to predict the genetic susceptibility to diseases in special communities. Polymorphism in cytokine genes are known to influence cytokine levels and may also be associated with susceptibility/resistance to tuberculosis or outcome and clinical forms of this disease (9)(10)(11)(12)(13). The pattern of cytokine gene polymorphisms is different in various populations (14).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Genetic Polymorphisms of TNF-α and IL-10 Genes Between Tuberculosis Patients and Healthy Blood Donors

Metanat

Narooie‐Nejad

Salehi

et al. 2013

Arch Clin Infect Dis

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Association of TNF-α and IL-10 polymorphisms with tuberculosis in Tunisian populations

Cited by 44 publications

References 36 publications

Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?

Comparison of Genetic Polymorphisms of TNF-α and IL-10 Genes Between Tuberculosis Patients and Healthy Blood Donors

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