2023
DOI: 10.21873/invivo.13382
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Association of Torsade de Pointes and QT Prolongation With Antifungal Triazoles: Analysis Using a Pharmacovigilance Database

KATSUHIRO OHYAMA,
SHOTA AKIYAMA,
MEGUMI IIDA
et al.

Abstract: Background/Aim: Torsade de pointes (TdP)/QT prolongation (QTP) is one of the most life-threatening adverse effects of antifungal triazoles. The aim of the present study was to evaluate the association of antifungal triazoles with TdP/QTP by age group and the profile of the time of TdP/QTP onset by analyzing the spontaneous adverse event database for Japan. Patients and Methods: Data registered in the Japanese Adverse Drug Event Report database (JADER) from April 2004 to March 2022 were analyzed. The associatio… Show more

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“…To account for covariates and enable adjustment via logistic regression analysis (21)(22)(23), the adjusted ROR (aROR) was calculated following established methodologies (24,25). Only reports containing complete information on sex and age were considered for aROR calculation.…”
Section: Disproportionality Analysismentioning
confidence: 99%
“…To account for covariates and enable adjustment via logistic regression analysis (21)(22)(23), the adjusted ROR (aROR) was calculated following established methodologies (24,25). Only reports containing complete information on sex and age were considered for aROR calculation.…”
Section: Disproportionality Analysismentioning
confidence: 99%