2022
DOI: 10.1001/jamanetworkopen.2022.7074
|View full text |Cite
|
Sign up to set email alerts
|

Association of Treatment With Antipsychotics, Antidepressants, or Both With Movement Disorders and Seizures Among Children and Adolescents With Depression in Korea

Abstract: Key Points Question Is treatment with antipsychotics in children and adolescents who are taking antidepressant medications associated with neurological adverse events? Findings In this cohort study of 9890 children and adolescents prescribed antidepressants for depression, the hazard ratios of movement disorders and seizures with adjuvant antipsychotics were 2- to 3-fold higher compared with antidepressant monotherapy. Hazard ratios increased with increasin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 46 publications
(86 reference statements)
0
3
0
Order By: Relevance
“…The high seizure risk during QTP treatment is well known [ 82 , 83 ], whereas, contrary to clozapine [ 84 ], the dose dependence of the seizure risk of QTP remains to be clarified. For QTP-induced seizure, the timing appears to range from several hours to one day after the supratherapeutic dose of QTP is administered [ 85 , 86 , 87 ].…”
Section: Discussionmentioning
confidence: 99%
“…The high seizure risk during QTP treatment is well known [ 82 , 83 ], whereas, contrary to clozapine [ 84 ], the dose dependence of the seizure risk of QTP remains to be clarified. For QTP-induced seizure, the timing appears to range from several hours to one day after the supratherapeutic dose of QTP is administered [ 85 , 86 , 87 ].…”
Section: Discussionmentioning
confidence: 99%
“…Antipsychotic medications incompletely treat psychosis symptoms and are associated with substantial adverse effects [9]. Additionally, there is evidence to suggest that antipsychotics can lower seizure threshold and increase seizure incidence [7,8], and undergo potential pharmacokinetic and pharmacodynamic interactions with antiepileptic drugs [7]. Thus, there is an immediate need for novel therapeutics to treat psychosis in TLE patients.…”
Section: Discussionmentioning
confidence: 99%
“…TLE patients are 6-12 times more likely than the general population to suffer from psychosis [5,6]; however, the management of psychosis for patients with TLE is currently inadequate. Both firstand second-generation antipsychotics are associated with an increase in seizure incidence, as they can lower seizure thresholds [7,8]. Additionally, antipsychotics often produce intolerable side effects that lead to the discontinuation of medication [9], and have potential pharmacokinetic and pharmacodynamic interactions with antiepileptic drugs [7].…”
Section: Introductionmentioning
confidence: 99%