Association of triglyceride glucose index with all-cause and cause-specific mortality among middle age and elderly US population

Sun, Mengxiong; Guo, Hongmei; Wang, Yi; Ma, Di

doi:10.1186/s12877-022-03155-8

Cited by 22 publications

(20 citation statements)

References 22 publications

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“…Numerous publications indicate that there is a nonlinear relationship between TyG index and cardiovascular mortality 32 . Meanwhile, among the middle‐aged and elderly US population in the National Health and Nutrition Examination Survey (NHANES), the second quartile of the TyG index encompasses the lowest risk of cardiovascular mortality (hazard ratio 0.62; 95% CI, 0.43‐0.88) when compared with the first quartile 33 . Lower TyG index also demonstrates higher risk.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults

Jia

Zhu

et al. 2022

Journal of Diabetes

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Background: The triglyceride glucose (TyG) index is closely associated with subclinical atherosclerosis. However, the association remains inconclusive among obese and nonobese individuals.Methods: This prospective study was conducted in 5751 adults with normal carotid intima-media thickness (CIMT) at baseline. We divided the population into four groups based on the TyG index, which was calculated by the following formula: Ln (fasting triglycerides [mg/dL] Â fasting glucose [mg/dL]/2). Information on CIMT was acquired by ultrasonography. Incident elevated CIMT was defined as IMT values greater than 0.9 mm at follow-up. Odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between TyG index and elevated CIMT were estimated using multivariable logistic regression models.Results: After a median follow-up of 4.3 years, 722 (12.6%) individuals had progressed to elevated CIMT. Compared with the second quartile of the TyG index, the first and fourth quartile both conferred higher risks of elevated CIMT after adjusting for potential confounders. In the total population, the ORs for the first and fourth quartile were 1.29 (95% CI, 1.00-1.66) and 1.42 (95% CI, 1.11-1.83), respectively. Restricted cubic splines demonstrated an approximately U-shaped association between TyG index and elevated CIMT among the total and nonobese adults (P for nonlinearity <.05), but not in those with general or abdominal obesity.Xiaojing Jia, Yuanyue Zhu, and Yan Qi contributed equally to this study.

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Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults

Jia

Zhu

et al. 2022

Journal of Diabetes

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“…In addition, a study with more than 10 years of follow-up has found that the TyG index (as a surrogate for IR) was a significant risk factor for incident CVD/CHD with an issue that was more prominent among the younger population [33]. Moreover, the findings of Sun et al [34] showed that TyG index was associated with all-cause mortality and cause-specific mortality (CVD and malignant neoplasms) among middle age and elderly US population. These data support the utility of the TyG index as a reliable and valid marker of IR for risk stratification in the real world.…”

Section: Related Studiesmentioning

confidence: 99%

Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database

Zhang

Shi

Wang

et al. 2023

Cardiovasc Diabetol

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Background The triglyceride-glucose (TyG) index is a reliable alternative biomarker of insulin resistance (IR). However, whether the TyG index has prognostic value in critically ill patients with coronary heart disease (CHD) remains unclear. Methods Participants from the Medical Information Mart for Intensive Care III (MIMIC-III) were grouped into quartiles according to the TyG index. The primary outcome was in-hospital all-cause mortality. Cox proportional hazards models were constructed to examine the association between TyG index and all-cause mortality in critically ill patients with CHD. A restricted cubic splines model was used to examine the associations between the TyG index and outcomes. Results A total of 1,618 patients (65.14% men) were included. The hospital mortality and intensive care unit (ICU) mortality rate were 9.64% and 7.60%, respectively. Multivariable Cox proportional hazards analyses indicated that the TyG index was independently associated with an elevated risk of hospital mortality (HR, 1.71 [95% CI 1.25–2.33] P = 0.001) and ICU mortality (HR, 1.50 [95% CI 1.07–2.10] P = 0.019). The restricted cubic splines regression model revealed that the risk of hospital mortality and ICU mortality increased linearly with increasing TyG index (P for non-linearity = 0.467 and P for non-linearity = 0.764). Conclusions The TyG index was a strong independent predictor of greater mortality in critically ill patients with CHD. Larger prospective studies are required to confirm these findings.

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“…The TyG index has been reported to be a composite biochemical indicator that reflects the combined effect of glucose and lipids [ 20 ]. The relationship between DR and abnormal glycolipid metabolism indicators has been extensively discussed [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

The U-Shape Relationship between Triglyceride-Glucose Index and the Risk of Diabetic Retinopathy among the US Population

Zhou

Zhang

et al. 2023

JPM

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Objective: To explore the association of diabetic retinopathy (DR) with TyG index and TyG-related parameters among the United States population. Methods: This cross-sectional study is conducted in adults with diabetes mellitus based on the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Multivariate logistic regression, restricted cubic spline, trend test, receiver operating characteristic curve and subgroup analysis are adopted to uncover the association of DR with TyG index and TyG-related parameter levels in diabetics. Results: An aggregate of 888 eligible participants with diabetes is included, involving 263 (29.6%) patients with DR. The participants are stratified according to the quartile of TyG index and TyG-related parameters (Q1–Q4). Following the adjustments of the confounding factors, a multivariate logistic regression analysis finds that TyG-BMI, TyG index and Q4-TyG index are significant risk factors for DR. The restricted cubic spline shows that TyG index and the DR risk of diabetes patients are proved to be U-shaped related (p for nonlinearity = 0.001). Conclusions: The triglyceride-glucose index has a U-shaped correlation with the risk of diabetic retinopathy, which has potential predictive value.

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Association of triglyceride glucose index with all-cause and cause-specific mortality among middle age and elderly US population

Cited by 22 publications

References 22 publications

Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults

Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults

Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database

The U-Shape Relationship between Triglyceride-Glucose Index and the Risk of Diabetic Retinopathy among the US Population

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