Association of triglycerides and new lipid markers with the incidence of hypertension in a Spanish cohort

Sánchez-Íñigo, Laura; Navarro‐González, David; Pastrana-Delgado, Juan; Fernandez‐Montero, Alejandro; Martínéz, J. Alfredo

doi:10.1097/hjh.0000000000000941

Cited by 100 publications

(98 citation statements)

References 40 publications

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“…Although TG/HDLc is a useful surrogate of IR, it varies according to sex and ethnicity . The existing literature shows that TG/HDLc is associated with hypertension . However, in this study, we did not find that TG/HDLc was significantly associated with hypertension, even in subjects with elevated BMI.…”

Section: Discussioncontrasting

confidence: 91%

“…27,28 The existing literature shows that TG/HDLc is associated with hypertension. 29,30 However, in this study, we did not find that TG/HDLc was significantly associated with hypertension, even in subjects with elevated BMI. The reason for the inconsistent results may be, on the one hand, the interethnic and sample size differences and, on the other hand, publication bias.…”

Section: Ir-compensatory Hyperinsulinemia Induces Carotid Body Overaccontrasting

confidence: 78%

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METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Liu¹,

Fan

Pan³

2019

J of Clinical Hypertension

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Insulin resistance (IR) plays a crucial role in the development of hypertension, so early recognition of IR is of substantial clinical importance for the management of hypertension. But traditional IR indexes are invasive, complex, and impractical. We aimed to evaluate the associations between three simple IR indexes and hypertension in different body mass index (BMI) categories. A total of 142 005 adults who did not take antihypertensive medication were included in this analysis. The ratio of triglycerides to high‐density lipoprotein cholesterol (TG/HDLc), the product of fasting triglycerides and glucose (TyG), and metabolic score for IR (METS‐IR) were calculated according to the corresponding formulas. The associations between them and hypertension were analyzed by logistic regression. Among the three indicators, only METS‐IR had positive correlations with blood pressure levels (all P < 0.001). After full adjustment, METS‐IR was significantly associated with hypertension in the normal BMI group but not in the elevated BMI group. The OR for hypertension in the normal BMI group in the highest quartile of METS‐IR was 2.884 (95% CI: 2.468‐3.369) in the total sample, 1.915 (95% CI: 1.614‐2.271) in females and 2.083 (95% CI: 1.717‐2.527) in males. Our findings indicate that METS‐IR, a simple and cost‐effective IR index, was strongly associated with hypertension in normal‐weight Chinese subjects. It could help monitor and manage hypertension in normal‐weight individuals.

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Section: Discussioncontrasting

confidence: 91%

Section: Ir-compensatory Hyperinsulinemia Induces Carotid Body Overaccontrasting

confidence: 78%

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Liu¹,

Fan

Pan³

2019

J of Clinical Hypertension

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“…Overall, this confirms that prediction of hypertension risk using METS‐IR could be explained by the increased cardiovascular risk associated with both IR and MS. Individual components of the METS‐IR score have also been linked independently to incident hypertension, including triglycerides and HDL‐C as well as BMI as a marker of whole‐body fat content . As demonstrated by our results, besides BMI, glucose levels are also highly predictive of arterial stiffness and incident arterial hypertension; despite this, the better model assessed by decreased in AIC was comprised by METS‐IR and not by its individual components.…”

Section: Discussionsupporting

confidence: 52%

“…Individual components of the METS-IR score have also been linked independently to incident hypertension, including triglycerides and HDL-C as well as BMI as a marker of whole-body fat content. 24,25 As demonstrated by our results, besides BMI, glucose levels are also highly predictive of arterial stiffness and incident arterial hypertension; despite this, the better model assessed by decreased in AIC was comprised by METS-IR and not by its individual components. This is significant, since it confirms that METS-IR is useful as a complementary metabolic evaluation tool when assessing risk of arterial hypertension.…”

Section: Discussionmentioning

confidence: 52%

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

Bello‐Chavolla

Antonio-Villa

Vargas‐Vázquez

et al. 2019

J of Clinical Hypertension

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Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non–insulin‐based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non–insulin‐based Metabolic Score for IR (METS‐IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non–insulin‐based IR indexes. We evaluated two populations, a cross‐sectional evaluation of high‐risk individuals (n = 305) with a wide range of metabolic comorbidities and dyslipidemia in whom PWV measurement was performed and a 3‐year prospective cohort of normotensive individuals (N = 6850). We observed a positive correlation between METS‐IR and PWV in the cross‐sectional cohort, which was higher compared with other non–insulin‐based fasting IR indexes; furthermore, PWV values >75th percentile were associated with the upper tercile of METS‐IR values. In the prospective cohort, we observed an increased risk for incident hypertension for the upper METS‐IR tercile (METS‐IR ≥ 46.42; HR: 1.81, 95% CI: 1.41‐2.34), adjusted for known cardiovascular risk factors, and observed that METS‐IR had greater increases in the predictive capacity for hypertension along with SBP and the Framingham Hypertension Risk Prediction Model compared with other non–insulin‐based IR indexes. Therefore, METS‐IR is a novel non–insulin‐based IR index which correlates with arterial stiffness and is a predictor of incident hypertension, complementary to previously validated risk prediction models.

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“…Using the TG/HDL-C ratio in particular is a practical approach for identifying individuals who have insulin resistance [7, 8]. Several studies have also revealed that the TG/HDL-c ratio is more closely correlated with the incidence of hypertension [9], coronary heart disease [10], CVD [11] and albuminuria [12] than individual lipid profiles are. Meanwhile, non-HDL-c is calculated as TC minus HDL-c and includes all the atherogenic lipoproteins [13].…”

Section: Introductionmentioning

confidence: 99%

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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Background/Aims: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. Methods: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m² or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD. Results: The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio. Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.

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Association of triglycerides and new lipid markers with the incidence of hypertension in a Spanish cohort

Abstract: : http://links.lww.com/HJH/A620.

Cited by 100 publications

References 40 publications

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

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