Association of Trophectoderm mRNAs and MicroRNAs with Chromosomal Aneuploidy of Embryo

Esmaeilivand, Masoumeh; Ghasemzadeh, Aliyeh; Niknafs, Behrooz; Fattahi, Amir

doi:10.1007/s43032-023-01381-y

Cited by 1 publication

(2 citation statements)

References 22 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessing blastocoel samples obtained from euploid and aneuploid blastocysts, the results revealed a significant increase of only miR-20a and miR-661 in the blastocoel fluid obtained from aneuploid embryos. Furthermore, the investigation extended to the examination of the selected miRNAs within the biopsied trophectoderm cells of the same blastocysts ( 18 ). The findings showed a significant downregulation of hsa-miR-30c and hsa-miR-372 levels in the aneuploid samples compared to the euploid blastocysts.…”

Section: Resultsmentioning

confidence: 99%

“…The role of miRNA in early development has been previously investigated, showing significant contribution in the process of implantation and stem cell differentiation ( 8 – 10 ). However, only limited studies have explored the potential of miRNAs in assessing developmental competence of early embryos, and the possible relationship between aneuploidy and miRNA expression ( 11 – 18 ). In this systematic review, our aim is to identify and combine the reported information on miRNAs with potential association to aneuploidy in preimplantation blastocysts.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review

Almutlaq,

Viñals Gonzalez,

SenGupta

2024

Front. Reprod. Health

View full text Add to dashboard Cite

IntroductionMicroRNAs are small noncoding genes with gene expression regulatory function. Their emergence as potential diagnostic biomarker for many diseases has gained a specific interest among researchers. Observations of changes in miRNA levels correlating with aneuploidy in early embryos raise the prospective of employing miRNA as biomarkers to assess the embryo quality.MethodTo identify and gather the miRNAs with potential link to chromosomal abnormalities in embryos from previous research, we conducted a systematic search using four databases, including Embase, Medline, Web of Science, and Cochrane databases in accordance with PRISMA guidelines.ResultsOut of 200 identified records, only seven met the inclusion criteria. Seven miRNAs: miR-19b, miR-517c, miR-518e, miR-522, miR-92a, and miR-106a exhibited persistent downregulation in aneuploid blastocysts in the included studies. These miRNAs are members of important miRNA clusters, associated with abnormal expression in studies on reproductive failure. Pathway analysis revealed their involvement in regulating gene transcription, as well as cell cycle progression and apoptosis.DiscussionThe changes detected in the miRNA expression in aneuploid embryos across different studies support the aneuploidy and miRNA relationship and prospect miRNA as a valuable tool for the assessment of embryo quality. Collectively, these observations highlight the role of miRNAs in embryonic development, and their involvement in genetic abnormalities that occur in embryos, such as aneuploidy, indicating their potential implementation to improve the embryo selection and reproductive outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%