“…Abundant literature exists on the pathogenesis of the anaemia while the exact mechanisms resulting in persistent reproductive losses have not been thoroughly elucidated. There had been a report of the association of trypanosomiasis with sperm and zona pellucida antibodies (Fayemi, 2003). Other researchers have earlier identified the pathogenesis of the reproductive failures in trypanosomosis to include pituitary hormonal defects or pituitary dysfunction (Apted, 1970;Isoun & Anosa, 1974;Griffin & Allonby, 1979) while some other researchers reported the absence of gross and histologic lesions in the endocrine and reproductive organs of infected animals (El-Hassan et al, 1994).…”